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Winkler Laboratory

@winklerlab.bsky.social

We are the Winkler Laboratory at the UKHD and DKFZ Heidelberg Our focus: #cancerneuroscience of #braintumors ( #glioblastoma #brainmetastases), and beyond. We use #intravitalimaging , #calciumimaging, #preclinicalmodels and more, to tackle these diseases

59 Posts1420 Follower405 Folgt
Erik@epikrisa.bsky.social · 4w ago

Now lectures on cancer neuroscience by Brain prize winners Winkler and Monje. Happy to be a small part of the field. I feel some hope for the future of currently lethal glioma in adults and children.

Areeba Patel@areebap.bsky.social · 2mo ago

1/n Excited to share our new paper in Nature Cancer 🦀 Meet Hetairos (Greek- “companion”): an AI model that predicts >100 methylation-defined CNS tumour subtypes directly from a routine H&E slide 🧠 State of the art diagnostics- from the slide that’s already on every pathologists’ desk 🧵

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Cancer Neuroscience Heidelberg@cn-hd.bsky.social · 3mo ago

📢 #CancerNeuroscience Online Seminar with Manuel Valiente from CNIO, Madrid, Spain. Title: Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity June 9, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...

Welcome! You are invited to join a meeting: Cancer Neuroscience Online Seminar - Manuel Valiente. After registering, you will receive a confirmation email about joining the meeting.

Manuel Valiente, DVM, PhD - Molecular and cellular rationale underlying the heterogeneous impact of metastases on brain activity

us06web.zoom.us

@nielsolshausen.bsky.social · 3mo ago

Super excited to see our new preprint on calcium signalling in brain metastases now out on bioRxiv! Very thankful to be part of @winklerlab.bsky.social and working so closely with @nilshebach.bsky.social under the guidance of @matthiakarreman.bsky.social and Frank Winkler and all our collaborators.

Matthia Karreman@matthiakarreman.bsky.social · 3mo ago

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

Nils Hebach@nilshebach.bsky.social · 3mo ago

Our new preprint on calcium signaling in brain metastases is now on bioRxiv! Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!

Matthia Karreman@matthiakarreman.bsky.social · 3mo ago

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · 3mo ago

Scientists from DKFZ and HI-STEM have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). This discovery lays an important foundation for more precise and long-term successful treatment strategies. @cp-cellstemcell.bsky.social t1p.de/brfxf

Leukemia stem cells cause treatments to fail - Findings open new avenues to overcome resistance

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). The...

t1p.de

Motori Lab@motorilab.bsky.social · 4mo ago

Check out this great review from @winklerlab.bsky.social and colleagues: cancer neuroscience is going to rewrite everything we thought we knew about oncology - and we're just getting started!🧠🔍

Winkler Laboratory@winklerlab.bsky.social · 4mo ago

What are the current and emerging topics in Cancer Neuroscience, and what comes next for the field? In our new review, now online @cp-cell.bsky.social, we discuss previous and ongoing research from leading laboratories and propose future directions for research. 🧠🔬 Curious? See link below 😀👇

Cell - a Cell Press journal@cp-cell.bsky.social · 4mo ago

New issue alert👉https://cell.com/cell/current On the cover: For the Hallmarks of Cancer's 25th anniversary, the cover illustrates its enduring impact across the cancer research community, uniting scientists, clinicians, patients, and educators to drive progress.

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Winkler Laboratory@winklerlab.bsky.social · 4mo ago

What are the current and emerging topics in Cancer Neuroscience, and what comes next for the field? In our new review, now online @cp-cell.bsky.social, we discuss previous and ongoing research from leading laboratories and propose future directions for research. 🧠🔬 Curious? See link below 😀👇

Cancer neuroscience: The past, the present, and the road ahead

Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, …

sciencedirect.com

Trends in Cancer@cp-trendscancer.bsky.social · 4mo ago

Neural circuits in lung adenocarcinoma modulate immunosurveillance

Neural circuits in lung adenocarcinoma modulate immunosurveillance

Recent evidence from a study published in Nature by Wei et al. reveals a bidirectional tumor–brain axis in lung cancer that suppresses immune surveillance by reprogramming macrophages and disabling T cell responses. These findings highlight neuroimmune signaling as a key regulator of cancer progression and a promising therapeutic target.

dlvr.it