Time for #sicily #sketchbook dump! It was very hot and I had limited patience and I got sweat all over the pen and paper. Night drawing was a bit easier.
Mark Kennedy
@mrmonkington.bsky.social
Head of Technology, MicrobesNG Head of Lunch, Brighton, UK Also this guy https://hostux.social/@mrmonkington And this guy https://www.instagram.com/mrmonkington/ Oh and https://github.com/mrmonkington
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
science.org
This this this. Nothing interrupts thought like the bland blue line.
Ian Dunt@iandunt.bsky.social · 4d agoWhenever I express a passably interesting thought or write a sentence with an interesting structure, Google docs puts a blue line under it & starts complaining. I'm starting to consider those error lines proof that I'm saying something worthwhile. If the document looks clean I've probably fucked up.
if we stopped vilifying salt and encouraged people to season well when cooking, they would be more satisfied with their own cooking and would eat less processed and take out food
Favourite cheeseS: - decent stilton (my first love) - ripe langre or other non Newtonian cheese - a little pyramidal crottin style goats cheese I got at a market in the ardeche when camping which I've never been able to get since. It tasted of muscat grapes - very old gouda with the crunchy bits
Tom & Lorenzo@tomandlorenzo.bsky.social · 2w agoPeople on Bluesky sigh and talk about The Discourse as if it were something required of them instead of something they opt to partake in, day in and day out. You really don't have to. Post about your favorite cheese
If AI has taught us anything it's that we really need to differentiate lowercase L better in sans serif fonts
Give your £50 to someone to whom it does make a difference then?
Sky News@news.sky.com · 3w ago'£50 doesn't even buy a meal': What people think of Burnham's electricity VAT cut
Good to see Jim Davidson on bluesky I was starting to worry
Anon Opin@anonopin.bsky.social · 4w agoA woman on her own will still cook herself a healthy, delicious dinner every day. A man on his own will alternate his dinners between toast, cereal and a Pot Noodle.
I love this! I used an SGI Indy and one of those leet monitors at Ricardo modeling tiny parts of car engines for a summer, and it really was so incredibly cool to nerdy little me. My win 95 PC bought with my gap year earnings was a bit of a let down in comparison.
brad sucks@bradsucks.bsky.social · 4w agoJurassic Park computers in excruciating detail by @fabinou.bsky.social fabiensanglard.net/jurrasic_par...
Well this Sam Neill quote blindsided me for some reason
This is one of the most insane and irresponsible things I have _ever_ seen from @theatlantic.com. And that's saying a lot. Just unbelievable stuff.
At the end of the term I asked my college creative wriing students to submit anonymous thoughts on AI. No real surprises: Mood ranges from resignation to despair, capitulation from embittered erosion of standards to total, feelings of betrayal from deep to furious. 1/
It was inevitable, wasn't it🙄 Of course the Telegraph would run with something like this👇 So let's remove some of the rose-tinted spectacles and also look at some of that data comparing 1976 with modern heat waves Because the 1976 nostalgia porn is wearing a bit thin at this stage 🧵1/23
My granddad's solution to hot weather was just to have another cup of tea
Guardians top 10 tips for keeping cool are like 1. Get some heat blocking blinds and fit them tomorrow 2. Don't wear jumpers 3. Become nocturnal and try just not to exist at day 4. I dunno change species to a more heat tolerant one 5... What a stupid article www.theguardian.com/thefilter/20...
Reading the Wikipedia entry for taste in humans and honestly this diagram looks more like a guide to assembling a burger from bits of brain. Or vice versa. Not sure which is worse.
If Reform ends up in government, they will be responsible for heavy stuff. Responses to terror attacks. Making war. National emergencies. The shitposting mentality is an insult to all of us.
I think 3 largest sources of practical learning for me in the past 10 years: - Wikipedia = reference - YouTube = techniques - Reddit/stackoverflow= crowd sourced problem solving ...and we're proposing to take two of those away from young people?! There has to be some nuance to all this.
Always had a fondness for Hockney's early work. Perhaps because his British suburban imagery was so familiar to me.
New blog post! I analyse the new hac@v6.0.0 basecalling model from @nanoporetech.com and discuss the conspicuous lack of a new sup model: rrwick.github.io/2026/06/11/d...
Dorado v2.0.0: no more sup?
a blog for miscellaneous bioinformatics stuff
rrwick.github.io
I have to say, listening to the Today programme dedicate an entire (context free) section about whether migrants are more likely to be convicted criminals *the morning after* hundreds of non-migrants of my own ethnicity committed a pogrom is blood boiling.
What an embarrassing load of lazy slop @brighton-hove.gov.uk this isn't a plan it's rushed homework www.theargus.co.uk/news/2616672...
