🚨New Pre-print Really excited to see this manuscript out. While short, this was a lot of work with troubleshooting and optimisation at all stages and will, hopefully, be the start out groups major focus. Microbial evolution studies..(1/7) #MicroSky #UTISky www.biorxiv.org/content/10.6...

In vitro evolution of uropathogenic Escherichia coli to fosfomycin resistance in a 3D cultured human bladder microtissue model

In vitro studies of antimicrobial resistance (AMR) using laboratory growth media produce important, fundamental information. However, their inability to more closely replicate the in vivo environment ...

biorxiv.org

🧪🐍 New paper accepted! We screened 14 snake venoms for antimicrobial activity and identified candidate venom proteins with activity against E. coli, including phospholipases and neurotoxins. A cool example of looking for new antimicrobials in unexpected places. doi.org/10.1099/acmi... #MicroSky

Screening the antimicrobial properties of snake venoms: an iterative fractionation approach

Antimicrobial resistance (AMR) increasingly poses a significant global health challenge. New antimicrobials are desperately needed, driving the need to explore novel sources of natural products. Snake...

doi.org

Welcome for complicated UTIs w/ resistant bugs but oral carbapenem lower the last barrier protecting this important antibiotic class Convenience for patients must not become convenience for prescribers, otherwise we may pay with increased carbapenem resistance #AMR www.cidrap.umn.edu/antimicrobia...

FDA approves new oral antibiotic for complicated urinary tract infections

Utebzi is the first oral carbapenem antibiotic approved in the US.

cidrap.umn.edu

Excited to see our latest paper out! @murraybeno.bsky.social & colleagues created an elegant in vitro platform in which #BladderCancer spheroids are embedded into our healthy human urothelial model, 3D-UHU, for studying biology and treatment. #urology #cancer short 🧵[1/4] doi.org/10.1038/s414...

An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing - British Journal of Cancer

British Journal of Cancer - An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing

doi.org

Really happy my PhD work has been published! Thank you to all who contributed! We developed a new microtissue model for bladder cancer and use it to test conventional Mitomycin C chemotherapy and a novel oncolytic virus. @jennyrohn.bsky.social @jinhuigao.bsky.social doi.org/10.1038/s414...

An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing - British Journal of Cancer

British Journal of Cancer - An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing

doi.org

🦠 Scientists solved a 30-year mystery showing how gut bacteria capture viruses using tail-like structures called nanotubes. #Microbiology #Virology #GutMicrobiome #Bacteria #Science via @sciencex.bsky.social

Solving a 15-year mystery: Scientists discover how gut bacteria toxin invades colon cells to trigger cancer

Since a landmark 2009 study, researchers have known that a common gut bacterium, Bacteroides fragilis, drives colon tumor formation, potentially leading to colorectal cancer, by secreting a toxin…

buff.ly

Great day presenting my poster at UTIGA conference in Nashville. Loads of positive feedback and amazing collaborations! What a great community to be part of! More importantly, a massive well done to @victoriachu.bsky.social for a brilliant talk today! Nailed it! 👌 #UTICONF26 #UTISky #UTI

Here’s (most of) the Rohn Lab for the launch of globalUTI.bluesky.social UTIGA26! @nickyuen.bsky.social @microberamon.bsky.social @victoriachu.bsky.social @fratorelli.bsky.social @murraybeno.bsky.social #UTICONF26 #UTISky #UTI

Next, 4 posters about a wide variety of great stuff - bladder flow modelling, phage therapy, catheter UTI, virulence mapping, and the gut/bladder axis @murraybeno.bsky.social @microberamon.bsky.social @nickyuen.bsky.social @fratorelli.bsky.social #UTISky #UTICONF2026

So proud of the team, presenting our work on #UTI using human-cell modelling. First, @victoriachu.bsky.social gave a fantastic podium presentation on her kidney-ureter-bladder chip to study ascending infection #UTISky #UTICONF2026 1/2

specifically decided upon by them. It was wonderful working with such a diverse group, from patients with lived experiences, clinicians to researchers on this. More detail on the approach, top 10 priorties, priorties outside the top 10, etc if you follow the link below (3/3) amr-action-uk.org/psp/

..improve treatment, diagnostics and outcomes for patients. Here, we present the top 10 priorties for recurrent and chronic UTI research. These are areas which are important to patients suffering from recurrent and chronic UTIs, their families and careers and healthcare professionals and were (2/3)

Recurrent and chronic UTIs have a huge impact on patient's quality of life and is an area of research which is often overlooked and understudied. There are massive gaps in our understanding which we can fill to... (1/3) See all images in this post and that follow for the top 10! #MicroSky #UTISky

Just over 1 week left to apply for this, please get your applications in asap! Again, please get in touch with me if you want to discuss any aspect of the project informally. Please share widely.

Alasdair Hubbard@dralhubb.bsky.social · 7mo ago

🚨 Fully‑funded PhD for Home Students🚨 Explore alternative therapies for UTIs, how they work and interact with antibiotics and help shape new solutions to AMR! Join a our supportive team at UoN and make real impact in infection research. #MicroSky #UTISky Apply now: tinyurl.com/38u552bu

From a biofilm to another: when bacteria from Dry Surface Biofilms settle in invasive medical devices. This study aims to reproduce in vitro the cross-transmission of bacteria from dry surfaces to invasive medical devices via healthcare professional’s gloves https://ow.ly/WMaj50Ygy8l

How #bacteria may promote #breast #cancer ... | #microbes | #pathogens | #gut | #oncology | #spermineoxidase | By @jhu.edu via @sciencex.bsky.social

How bacteria may promote breast cancer

Researchers at the Johns Hopkins Kimmel Cancer Center have discovered how certain pathogenic bacteria in gut and breast tissue can promote breast cancer development and progression by hijacking a key…

medicalxpress.com

Today, UCL turns 200. 🎉 For two centuries, our community has opened doors, challenged convention and pushed the boundaries of knowledge across every discipline. Thank you to everyone who’s been part of the UCL story, here’s to the next century. ✨ #UCL200 #LoveUCL

It’s been brilliant having a visiting delegation all this week from the labs of @nicoledenisco.bsky.social & @chelsamicro.bsky.social, who’ve come all the way from 🇺🇸 to 🇬🇧 to learn how to grow our 3D-UHU bladder model. The lab is bursting at the seams but we’re having a lot of fun! #UTISky #UTI

Proud to present my work at the UK Cellular Microbiology Network Meeting earlier this week. Lots of great feedback and some very interesting talks! Congrats to all the speakers. Well done @microberamon.bsky.social for representing the lab. I like the rainbow title slide 😂 @jennyrohn.bsky.social

From over 300k to less than 100k. A picture of smaller, reduced science.

Absolutely thrilled this is out🥳Our review explores why antibiotics often fail even when bacteria is susceptible in the lab. From phenotypic resilience and biofilm formation to host microenvironment, we dive into many factors behind these discrepancies www.nature.com/articles/s44...

Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing - npj Antimicrobials and Resistance

npj Antimicrobials and Resistance - Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing

nature.com