Nicholas Tolley

@ntolley.bsky.social

Postdoc in comp neuro @BrownU, interested in biophysical modeling, deep learning, and open-source software development

📢PhD job alert! A exciting PhD project that involves using MEG and biophysical modelling to try to predict effects of a glutamatergic treatment for psychosis... plus you can develop your own side project. Join our great team! www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

Super glad to have our team's work on clinical applications of neural simulations highlighted in this article! Trying to bring academic work to the real-world has been a great experience and I'm quite excited to continue these efforts with @dvwz.bsky.social and @jonescompneurolab.bsky.social

Carney Institute for Brain Science@carneyinstitute.bsky.social · 3mo ago

Meet the trainees co-founding companies to defeat Alzheimer’s disease and other disorders! Larry Heller, Ryan O'Rourke, @dvwz.bsky.social and @ntolley.bsky.social share the story of their entrepreneurial journeys. carney.brown.edu/news/2026-05-05/ad-spin-offs

Headed to #SOBP2026? Come visit our posters on stress and mental effort! F325: Investigating the Role of Serotonin in Stressor Controllability and Mental Effort Allocation (me!) S297: Learning and Generalization of Stressor Controllability for Mental Effort allocation (Tony El Nemer)

Really excited for this conference! We’ve all been digging deep into different ways to use EEG to better understand and treat psychiatric diseases If you’re at SOBP definitely stop by our posters if you want to chat biophysical mechanisms, biomarkers, and deep learning approaches to EEG analysis

Human Neocortical Neurosolver@hnnsolver.bsky.social · 3mo ago

We will be at the SOBP conference this week! Come see our exciting lineup of posters on psychiatric translational applications of HNN and similar mechanistic models. Presented by @ntolley.bsky.social, @darcywaller.bsky.social , Stephanie R. Jones, David Zhou, and Pran Chanthrakumar.

New work, now out in PLoS Biology. Using intracranial recordings & EEG, we find that the human STN rapidly engages / releases motor inhibition depending on task context, does so in tight accord w/ frontal cortex, and shows little to no lateralization while doing so. journals.plos.org/plosbiology/...

A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context

How does the human brain stop movements under realistic conditions? Using intracranial recordings and multi-variate EEG decoding, this study shows that a fronto-basal ganglia circuit featuring the sub...

journals.plos.org

Jan R. Wessel@janw.bsky.social · 7mo ago

New preprint from the lab, led by post-doc @cheolsoh.bsky.social and former post-doc Mario Hervault (now Asst Prof at UGrenoble). The boys used synchronous intracranial recordings from the human subthalamic nucleus & EEG to study β bursts during global & selective response inhibition. Details in 🧵

[ #ICLR2026 ] How do we know if two systems are performing the same computation when they are constantly driven by different external inputs? 🧠🤖 I’ll be presenting our novel method InputDSA tomorrow April 23 (2:15pm-4:45pm EDT in Pavilion 3 P3-#1614)📍 Come swing by our poster! I’d love to chat!

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Kanaka Rajan@kanakarajanphd.bsky.social · 4mo ago

✍️ In the @kempnerinstitute.bsky.social blog: our new tool built to compare the dynamics of complex systems when both internal circuitry and external inputs shape their behavior. Catch @annhuang42.bsky.social presenting this work at #ICLR! kempnerinstitute.harvard.edu/research/dee...

Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...

Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey - Scientific Data

Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey

nature.com

Really excited to share a new preprint! 𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻𝘀 𝘀𝘁𝗮𝘆 𝗿𝗼𝗯𝘂𝘀𝘁 & 𝗲𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝘄𝗵𝗶𝗹𝗲 𝗯𝗲𝗶𝗻𝗴 𝗶𝗻𝗰𝗿𝗲𝗱𝗶𝗯𝗹𝘆 𝘀𝗽𝗮𝗿𝘀𝗲? We explore how! www.biorxiv.org/content/10.6... We built Connectome-based Neural Networks (CoNNs) using Drosophila wiring (larva&adult) & compared with random networks with same sparsity.

Constructing connectome-based neural networks