So… they’re working

How exciting to get an email that starts with "We are pleased to inform you that..."!!! 🥳 I am grateful to receive two years of research funding from the American Heart Association to unravel the intricacies of phospholipid scrambling by TMEM16F that plays an important role in blood clotting.🩸

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

"I heard you like AI. So I applied an AI to rewrite my AI-generated manuscript about my new AI model to make it sounds less AI." 🤦

Nature@nature.com · 4w ago

A new academic ‘humanizer’ tool aims to personalize the tone of research papers written with an AI program by erasing apparent signs of AI usage go.nature.com/4aJ3uRP

Had the privilege to attend the 75th Lindau Nobel Laureate Meetings this week. So grateful for UC sending me 🙏🏼 Met so many inspiring people, young scientist and Nobel laureates alike! Danke Danke Danke #LINO75

📣 Hear! Hear! 🦋 Behold this Bluetorial on a cool paper written with my PhD student Nathaniel Wesnak 🧪 If you want to dive into the rabbit hole of lipid flop-flop and its description as a stochastic process—here’s your TEASER TRAILER on some flippin’ awesome work: doi.org/10.1063/5.03... 1/26

Stochastic process description of lipid flip-flop

Since lipid bilayers are self-assembled macroscopic aggregates, their constituent lipid molecules can spontaneously transition between the two leaflets. This so

doi.org

Cool paper alert 🚨! Congrats @olzmannlab.bsky.social! Proud to have made a small contribution to this. One of the prettiest membrane-protein structures I have simulated ☺️

James Olzmann@olzmannlab.bsky.social · 5mo ago

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Our paper on The Lipid Interactome is now published, and the database is open: lipidinteractome.org @ohsummi.bsky.social @ohsunews.bsky.social @nadlerlab.bsky.social @jeremybaskin.bsky.social Please RT to spread the word. doi.org/10.1093/bioi...

The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions

AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon

doi.org

Poster is up! Come chat at poster B198 if you wanna learn about MD simulations of TMEM16 lipid scramblases 🤓 #bps2026

Aptly decorated floor at the Membrane Structure and Function subgroup session ❤️ #bps2026

Let’s go!! #bps2026

As a martini simulator, lipid enthusiast, and map nerd, I absolutely love this one! 🌎

Kresten Lindorff-Larsen@lindorfflarsen.bsky.social · 8mo ago

The Martini globe. The lipids of the globe are coloured by their continent based on the tectonic plates. The Kingdom of Denmark is coloured dark red. By @fabianschuhmann.bsky.social @cg-martini.bsky.social @weria-lab.bsky.social et al in doi.org/10.1021/acs....

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

May lipid scramblases be selective after all?! New @pnas.org paper showing that TMEM16F prefers PS and PC over PE in the complex context of a real plasma membrane. www.pnas.org/doi/10.1073/...

A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membrane | PNAS

The asymmetric resting distribution of the three major phospholipid classes on the mammalian plasma membrane, with phosphatidylserine and phosphati...

pnas.org

Evo-MD strikes again! Unraveling the physics of cholesterol attraction by transmembrane proteins. @natcomms.nature.com www.nature.com/articles/s41...

Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction - Nature Communications

Cholesterol plays a key role in membrane biology. Here, authors employ evolutionary molecular dynamics simulations to explore interactions driven by linear protein sequences, challenging the predictiv...

nature.com

🤯

Gioele La Manno@gioelelamanno.bsky.social · 10mo ago

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Thanks to @snsf.ch, we are hiring two PhD students to investigate frontier topics in lipid biology using a combination of MD simulations and experiments. Preferred starting date: ASAP. Fribourg - and Switzerland - are quite nice, for both work and private life! Please spread the word!

Now published as a "version of record" at @elife.bsky.social elifesciences.org/articles/105...

eLife@elife.bsky.social · 11mo ago

27 simulations of capturing hundreds of lipid scrambling events reveal mechanisms of lipid translocation. However, according to reviewers, more evidence is needed on outside-the-groove scramblase activity. buff.ly/LTxy4yX

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

Looking forward to this one!

Biophysical Society@biophysicalsoc.bsky.social · last yr.

Join the Membrane Structure and Function Subgroup will be hosting a webinar on Tuesday, March 25 at 11:00 AM ET. The presentations will explore recent breakthroughs, foundational concepts, and future directions in membrane biophysics. Register here: buff.ly/YOAPVID

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...

Wrapped up #BPS2025 with a scenic bike ride to Griffith observatory. This week was a blast! See you next year in SF 🌁 @biophysicalsoc.bsky.social

So much cool science at #bps2025! I’ll present my work on designing lipid scramblases tomorrow at 11 am.

✅ Arrived in #LA ✅ Funded 20 bicycles for World Bicycle Relief Now refocus on some awesome science at #bps2025 @biophysicalsoc.bsky.social I will keep the fundraiser open for another week, so donations are still welcome 🙏🏼

Day 4 ✅ Tough day of riding in the rain. Happy to take a rest day tomorrow. #santabarbara has awesome #bike infrastructure! Donations 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten

Day 3 ✅ Making the most of the sunny weather. Getting closer to LA and #bps2025! Donations 🙏🏼: www.powerofbicycles.org/fundraisers/...

Day 2 ✅ Getting closer to #bps2025 with every pedal stroke. Donations to World Bicycle Relief ➡️ www.powerofbicycles.org/fundraisers/...

On my way to #bps2025 @biophysicalsoc.bsky.social I’m biking from SF to LA to promote low-emission transportation and raise money for World Bicycle Relief. Donations: 🙏🏼 www.powerofbicycles.org/fundraisers/niekvanhilten

Our paper is now out in @elife.bsky.social! We performed @cg-martini.bsky.social MD simulations to capture >700 lipid scrambling events in 27 TMEM16 structures to systematically study their lipid scrambling rates and mechanisms. 📃 doi.org/10.7554/eLife.105111.1

From 9 to 14 February 2025, I embark on a 550 mile (900 km) bike adventure from San Francisco to Los Angeles to attend the annual BPS meeting @biophysicalsoc.bsky.social. On this trip, I strive to (1) raise money for World Bicycle Relief, and (2), to promote low-emission travel. A thread 🧵: