A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER membrane, which converts small lipid changes into a cooperative transcriptional response. www.biorxiv.org/content/10.6...

ER cholesteryl ester phase separation underlies switch-like cholesterol sensing

Cellular lipid homeostasis requires mechanisms that detect subtle changes in lipid abundance and trigger rapid, coordinated responses. The INSIG/SCAP/SREBP2 pathway provides a central feedback system ...

biorxiv.org

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

It's nice when you benchmark your own method and find it good. But its even nicer when others benchmark your method and find it good. Figure from: Coarse-grained simulations of long intrinsically disordered proteins: a benchmark of Martini 3 force-fields doi.org/10.64898/202...

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 3w ago

Coarse-grained simulations of long intrinsically disordered proteins: a benchmark of Martini 3 force-fields https://www.biorxiv.org/content/10.64898/2026.07.17.739185v1

Team science preprint, exploring the capabilities and limitations of Alphafold3 across different application areas, including protein-RNA, protein-lipid, ubiquitination,TCR and antibody recognition with @ninjani.bsky.social @labvanni.bsky.social @dgfeller.bsky.social www.biorxiv.org/content/10.6...

Capabilities, specificity gaps and training-data dependence of AlphaFold3 across diverse application areas

Structure prediction models have moved from single proteins to assemblies that include diverse biomolecules and their modifications. AlphaFold3 (AF3) and related models extended structural modelling v...

biorxiv.org

Happy to share that this beautiful work by @mudgal17.bsky.social in collaboration with the Weis lab @eth-dbiol.bsky.social, discovering a new membrane fusion mechanism in eukaryotes, is finally out in peer-reviewed form at @cp-molcell.bsky.social. www.cell.com/molecular-ce...

A conserved mechanism of membrane fusion in nuclear pore complex assembly

Fischer et al. uncover a fundamental mechanism of membrane fusion during nuclear pore complex (NPC) assembly. Brl1 and Brr6 form ring-shaped, membrane-remodeling complexes that interact and bridge the...

cell.com

Vanni Lab at UNIFR, Switzerland@labvanni.bsky.social · last yr.

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social. How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

Check this mind-blowing story! How can a transmembrane protein adapt to a hugely diverse membrane topology to perform his job? Truly amazing in situ and integrative structural biology, and a great collaborative work by @veijosalo.bsky.social @yoelklug.bsky.social and @jennifersapia.bsky.social!

Veijo Salo@veijosalo.bsky.social · last mo.

How does a cell remodel the ER membrane into a lipid droplet? Excited to share our new bioRxiv preprint, where we find that regulated opening of the seipin ring defines a functional ER–lipid droplet interface — and identify SMLR1 as a regulator of this transition. www.biorxiv.org/content/10.6...

Beautiful cover on our Atg2-Atg18 work (with @ungermannlab.bsky.social, @arnemoeller.bsky.social and reggiori lab) by lab PhD student @yarasayed1.bsky.social. Congrats Yara! #lipidtime

The EMBO Journal@embojournal.org · 2mo ago

Issue 12: Comment on spatial metabolomics Review: Host/transposable element coexistence Method: One-step generation of T-cell receptor knock-in mice Phase separation of bacterial transcription terminator Cover: Sabrina Chumpen, @dmitryshvarev.bsky.social et al link.springer.com/journal/4431...

This amazing work by @danialv.bsky.social and Bodan Hu is now out in peer-reviewed form at @cp-cell.bsky.social with a lot of new simulations! Check it out if interested in lipid transport!

Vanni Lab at UNIFR, Switzerland@labvanni.bsky.social · 7mo ago

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

Please help me share this amazing opportunity: our neighbours at @merkleinstitute.bsky.social are hiring a professor in data-driven materials discovery. This is a truly excellent (teaching, budget, infrastructure...) position. Deadline is close: 31/05/26. jobs.sciencecareers.org/job/677463/p...

PROFESSOR (OPEN RANK) IN DATA-DRIVEN MATERIALS DISCOVERY (90-100%) - Fribourg, Switzerland job with University of Fribourg - The Faculty of Science and Medicine | 677463

The University of Fribourg, Switzerland, announces the opening of a position of Professor of Data-Driven Materials Discovery.

jobs.sciencecareers.org

Happy to share our latest work on bridge lipid transfer proteins, by PhD student @yarasayed1.bsky.social. A great collaboration with @ungermannlab.bsky.social @arnemoeller.bsky.social and Reggiori lab!

The EMBO Journal@embojournal.org · 3mo ago

Atg18 interaction positions Atg2 for efficient lipid transfer into phagophore elongation Sabrina Chumpen Ramirez, @dmitryshvarev.bsky.social  et al link.springer.com/article/10.1...

Three PhD positions available to work on yeast lysosome biogenesis and reconstitution of membrane fusion as of July or September 2026. Details can be found here: myshare.uni-osnabrueck.de/f/76c16d1fcc...

260508_PhD positions available.pdf

Share link for 260508_PhD positions available.pdf.

myshare.uni-osnabrueck.de

I am looking for a postdoctoral fellow to join my team to work on the interplay between endocytosis and autophagy. The 3-year project runs in collaboration with the Dagdas lab @plantophagy.bsky.social and can start asap. Interested candidates can apply via the link below. jobs.vib.be/apply/134365

The molecular basis of tricalbin-mediated membrane contact site organization in cells url: journals.biologists.com/jcs/article-...

The molecular basis of tricalbin-mediated membrane contact site organization in cells

Membrane contact sites facilitate molecular exchanges through physical interactions between organelles, connected by specific protein tethers. Among these tethers are the tricalbins, which mediate con...

journals.biologists.com

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Happy to share our latest work where @Jennifersapia.bsky.social teamed up with @veijosalo.bsky.social and Xuewu Sui from @tamu.bsky.social to combine simulations and experiments to investigate DGAT1-dependent triglyceride synthesis, revealing more roles for DAG than previously known….(1/3)

Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎 doi.org/10.1038/s420...

GlycoShape@glycoshape.org · 5mo ago

Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

Biological Laboratory | LEGO® Ideas

This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

beta.ideas.lego.com

Congratulations @olzmannlab.bsky.social @arrudalab.bsky.social! Really outstanding and important work!

James Olzmann@olzmannlab.bsky.social · 5mo ago

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

Amazing PhD @cristianrocharoa.bsky.social and I have collected our thoughts and questions (many!) on lipid scramblases in this review: www.sciencedirect.com/science/arti... If you are interested in lipid transport and metabolism, membrane asymmetry and membrane protein function, give it a read!

Lipid scrambling: New players, new questions, new opportunities

Nearly a quarter of the proteins encoded in most organisms are transmembrane proteins. Contrary to textbook description, many feature a hydrophilic gr…

sciencedirect.com

New preprint from the lab together with @labvanni.bsky.social. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1. www.biorxiv.org/content/bior...

PhD positions in my lab (AI for Science), but with special preference for people who complement our current activities or are enthusiastic about contributing to our on going work. Looking for technically strong, independent and proactive candidates. www.chalmers.se/en/about-cha...

Please REPOST (“likes” don’t help in diffusion!) and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science

CRBM-Montpellier@crbm-montpellier.bsky.social · 6mo ago

We are hiring!

Please share!!! I am looking for a postdoctoral researcher to join us. Focus will be on exciting collaborative projects on lipids and membrane biology, pushing the boundaries of in silico "reconstitutions". Previous experience with molecular dynamics simulations of biological systems a strong plus!

We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime www.epfl.ch/labs/dangelo...

Master Projects

DANGELOLAB

epfl.ch

Please share🙏: Our lab opens 2 PhD positions to investigate fungi's evolution: #Barcelona Wet lab in Biochemistry/Structural Biology of cryo-tolerant fungi www.upf.edu/documents/d/... Computational in Physical Chemistry of cellular processes under extrem environments www.upf.edu/documents/d/...

I finally made my webpage, check it out: pilarcossio.org

New preprint from the lab! Triglycerides act like salt on ice: they solubilize cholesterol esters and drive lipid droplet growth. The TG/CE ratio shapes both droplet size and proteome, mirroring lipoprotein organization. www.biorxiv.org/content/10.6...

The work by @danialv.bsky.social is now out in @pnas.org with a few changes after peer-review. Have a look if you are interested in lipid transport by bridge lipid transfer proteins (BLTPs)... www.pnas.org/doi/10.1073/...

Vanni Lab at UNIFR, Switzerland@labvanni.bsky.social · 12mo ago

Happy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social‬. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...

Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...

Experimental tour-de-force from Anne-Claude Gavin's lab: selectivity mapping of 39 lipid transfer proteins reveals ~500 new LTP-lipid pairs. Molecular modeling by @mahmoudmoqadam.bsky.social, @rezatalandahti.bsky.social & Florian Echelard. @cbubergen.bsky.social www.nature.com/articles/s41...