Osvaldo Burastero
@osvalb.bsky.social
Biophysics enthusiast. Currently focused on data analysis: https://spc.embl-hamburg.de
Do you want to study the stability of a designed protein that doesn't unfold below 90 ºC 🔥? Combine a denaturant and temperature and then analyse the results with our newest tool: CheMelt 🧪 Online: - spc.embl-hamburg.de/app/chemelt As Docker image (faster): - hub.docker.com/r/emblspc/ch...
Interested in protein biophysics?🧪 Sign up for the @springernature.com webinar (08/04) where we will present the MOSBRI project outcomes @mosbri.bsky.social, including the eSPC platform (spc.embl-hamburg.de) and the Molecular Biophysics Database (mbdb-data.org) 🙌 Info here: tinyurl.com/rdfsp4nv
Do you have to create a scientific poster? 🧪 I have created a basic Figma template for it. Hope it helps 👐: github.com/osvalB/figma...
New protocol out now! 📕🖊️🔍 A practical workflow for analyzing CD thermal unfolding of short RNAs — from SVD decomposition to two-state fitting to extract melting temp and enthalpy with ChiraKit. A must-see if you’re working with RNA structure and CD data. DOI: 10.1007/978-1-0716-5084-4_12 
We’re looking for a GL! Join us at EMBL Hamburg! 🧫🦠🧬 The position will be based at CSSB @cssbhamburg.bsky.social , an interdisciplinary research centre focused on infection biology, and will be integrated into EMBL's research programme. @embl.org Find out more and apply here: lnkd.in/dJU9pee7
EMBL@embl.org · 11mo agoFor additional open calls for leadership roles at EMBL, also check out: embl.wd103.myworkdayjobs.com/EMBL We’re looking for: Hamburg: Group Leader Grenoble: Group Leader Heidelberg: Two Group Leaders, Team Leader, Unit Head
EMBL-EBI ARISE fellow @melanieschneider.bsky.social & EMBL Grenoble’s Marquez team developed EnsembleFlex 🖥️! It can analyse flexibility, identify protein states, and show drug binding, providing new insights into protein dynamics! doi.org/10.1016/j.st...
Do you want to analyze mass photometry (MP) count data with Python scripts? Try pyPhotoMol, a package to process, fit, and visualize the MP data 👨💻 github.com/osvalB/pypho... pyPhotoMol is derived from PhotoMol, our web tool for MP: spc.embl-hamburg.de/app/photoMol #massphotometry #Python #code
Happy to present the next tool under development. KinGenie, for binding kinetics. It already supports biolayer interferometry input files. Try it here: spc.embl-hamburg.de 🎉🎉🧪🧪
eSPC platform
spc.embl-hamburg.de
SPC Facility & Garcia-Alai Lab@spcembl.bsky.social · last yr.KinGenie, an online tool for the analysis of kinetics data, has been introduced on the 4th MOSBRI Scientific Conference in Paris, France 🇫🇷 A great addition to our eSPC web server💡🚀 Reach out to us for further input! @osvalb.bsky.social @mosbri.bsky.social @embl.org @cssbhamburg.bsky.social
ChiraKit, our tool for circular dichroism, has been published in NAR 🎉🎉👨🔬👨🔬. @narjournal.bsky.social
SPC Facility & Garcia-Alai Lab@spcembl.bsky.social · last yr.🔊 Thrilled to share our latest work, just published in NAR! 📃 We present ChiraKit, open-source tool to process raw CD data and perform advanced analysis! Access via our eSPC web-server! ➡️ spc.embl-hamburg.de @osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social
Just want to say thanks to @spcembl.bsky.social for developing ChiraKit and allowing quick and informative analysis of CD data - more here www.biorxiv.org/content/10.1... best news of the day today as we were stuck with beautiful but hard to analyze data 🙂 #scienceisawesome
ChiraKit, an online tool for the analysis of circular dichroism spectroscopy data
Circular dichroism (CD) spectroscopy is an established biophysical technique to study chiral molecules. CD allows investigating conformational changes under varying experimental conditions and has bee...
biorxiv.org
Interested in antimicrobial resistance and drug discovery? Attend the talk of my colleague and partner Tania Szal 😊 Monday 17th at 8:30. Platform: protein-small molecule interactions I #BPS2025
Looking forward to making new connections at #BPS2025👨 Meet me at poster B38 on Tuesday 18 Feb 13:45. Session "protein stability folding and chaperones"
Just finished a science poster (in Figma) and wanted to share the template I used! 🎨 Hope it's useful: github.com/osvalB/figma...
Scientists at University of Buenos Aires, EMBL Hamburg, and others mapped yerba mate’s genome, providing surprising facts about its biochemistry and evolution of caffeine biosynthesis. 🧉🧬🧪 Find out more: www.embl.org/news/science... @spcembl.bsky.social
After many months of gathering user feedback and improving our software, we think it's time to share it with the community. Enjoy our latest tool 🥳 , and stay tuned for the next one 😉
SPC Facility & Garcia-Alai Lab@spcembl.bsky.social · 2y ago🔊 Our latest biophysical tool for circular dichroism analysis, ChiraKit, is out 🔍 To read more about it, visit www.biorxiv.org/content/10.1... ChiraKit can be accessed at spc.embl-hamburg.de @osvalb.bsky.social @lucasdefelipe.bsky.social @embl.org @cssbhamburg.bsky.social @mosbri.bsky.social
Our colleagues in Prague have released a database for molecular biophysics data - mbdb-data.org! 🌍📊 A great step forwards FAIR data in biophysics. 🙌✨ @mosbri.bsky.social
Molecular Biophysics Database
mbdb-data.org
Instruct now has two R&D calls open - aimed at growing and advancing the global structural biology toolkit! - The pilot award is open to Early Career Researchers, with up to €15,000 available for any topic - The TechDev call in AI research awards up to €30,000 instruct-eric.org/rd-project-a...
R&D project awards - Instruct-ERIC
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
instruct-eric.org
Are you working with circular dichroism (CD)? Check out the latest update to our ChiraKit tool, now with 10 tutorials to get you started! 🚀 Try it here: spc.embl-hamburg.de/app/chirakit
The Sondermann group and collaborators @univofmaryland.bsky.social have identified a new family of bacterial enzymes termed diDNases. The research received a Breakthrough Article designation from Nucleic Acids Research. Find out more: t1p.de/i07ua
Journalist friend: you pay to publish your work? 😶 Me: yes, and we also review for free, and pay to read Friend: are scientists okay? Idk 😅
Apply now to learn about binding kinetics at the Institut Pasteur (April 2025) 🧪😁
Kelvin Lau @klausenhauser on 🙅♂️🐘🪡@klausenhauser.bsky.social · 2y ago📣 Do you like binding kinetics? Have already done some experiments and want to become more advanced? Join us for Kinetics 2025 @pasteur.fr ! Hands-on opportunity on instruments from almost all the vendors + Seminars + Data Fair discussion on data! #biophysics #kinetics www.mosbri.eu/training/adv...
So many people added to pack 1 this weekend we had to make pack 2. Makes sure you refresh for followers on pack one to see them all! 🧶🧬 go.bsky.app/DDetSBp
Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️
Anyone looking for a postdoc position? Apply to join our group in EMBL Hamburg 😊🧪
SPC Facility & Garcia-Alai Lab@spcembl.bsky.social · 2y ago📣We are looking for an enthusiastic postdoctoral candidate to work on an interdisciplinary project combining Biochemistry of extremophiles and Structural Biology! 🤝The position will be held in collaboration with Donato Giovannelli and Vikas Trivedi ! 📩Contact: Maria.Garcia@embl-hamburg.de
Not enough bioinformatics in your Bluesky feed? We’ve got you covered. Follow us for our latest news, exciting life science research, updates from our data resources, new tools and training resources. Haven't heard of EMBL-EBI? Take a look at what we’re working on. www.ebi.ac.uk/about/our-im...
Our impact
We provide open data that helps scientists understand life and that informs solutions to real-world problems, such as infectious diseases, climate change and food security.
ebi.ac.uk
Just out! 🥳🥳 Great work done at the @spcembl.bsky.social to understand clathrin-mediated endocytosis. We investigated how clathrin and adaptor proteins interact in vitro and in vivo. Kudos to the 1st author @lucasdefelipe.bsky.social! www.nature.com/articles/s41... www.embl.org/news/science...
Assisted to a meeting about FAIR (Findable, accessible, interoperable and reusable, or Foundational AI ready, depending who you ask😅) data. Main takeaway: FAIR is far in biophysics
