Very excited to share my postdoc work- out now at PNAS! Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

This is going to hurt science. 🧪 What hurts science hurts healthcare. 🩺 What hurts healthcare hurts you. 🫵 Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.

Alexandra Witze@alexwitze.bsky.social · 2y ago

This morning, the US National Science Foundation fired 168 employees, approximately 10% of its workforce, for no cause other than they were the agency's most recent hires. 🧪 Co-workers are leaving supportive messages before they have to clear out of the building at 5 p.m. Sent to me by a source ⬇️

Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH. Very thorough and clear. If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this... www.aau.edu/key-issues/i...

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants. grants.nih.gov/grants/guide...

⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants. —> Deep budget cuts & program closures coming to a university near you. Is this the break the glass moment for university administrators who have been silent so far about the attack on science?

Revised and Extended: What's Happening Inside the NIH and NSF | Science | AAAS www.science.org/content/blog...

Revised and Extended: What's Happening Inside the NIH and NSF

science.org

Shout out to Dr. Bishal Basak in @erikaholzbaur.bsky.social at @upenn.bsky.social for spearheading the work on identifying a new stress response pathway that regulates mitophagy in neurons! ➡️Read pre-print here: doi.org/10.1101/2024...

Aligning Science Across Parkinson's@asapresearch.parkinsonsroadmap.org · 2y ago

🎉 We are celebrating Bishal Basak from CRN Team Hurley as our January #NetworkSpotlight. Bishal worked on a Team paper where he identified a novel, neuron-specific mitophagy pathway. Thank you, Bishal! Check out Bishal's paper: www.biorxiv.org/content/10.1...

If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel. I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times! Pls repost 🙏❤️

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

NIH In Your State - United For Medical Research

Select a state on the map to see the impact of NIH funding across America.

unitedformedicalresearch.org

Step 1) find your rep www.congress.gov/members/find... Step 2) send an email or call their office Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days

Study sections are the review panels that allocate NIH research grants. They bring in experts from around the country and have to be scheduled many months in advance; they provide the funds that keep the nation's biomedical research going. It's hard to overstate the disruption this causes.

Jane Liebschutz, MD MPH (she/her)@liebschutz.bsky.social · 2y ago

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

The United States built a publicly funded scientific enterprise that worked miracles. We went to the moon and mars, laid the groundwork for computing revolutions, turned AIDS from a death sentence to a chronic condition, drastically cut cancer deaths. And now we're just going to dismantle it?

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

📣Now that @mito911.bsky.social is on Bluesky, let's highlight the research run in our team! Check out the pre-print by @palumbos.bsky.social Palumbos et al. and colleagues from the @erikaholzbaur.bsky.social! @asapresearch.bsky.social ⬇️

Erika Holzbaur-Howland@erikaholzbaur.bsky.social · 2y ago

Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...

Read the recent pre-print by @palumbos.bsky.social now on BioRxiv. In the meanwhile, find below and read a thread for a sweet preview of her work! 👩‍🔬 🧫 @asapresearch.bsky.social

Sierra Palumbos@palumbos.bsky.social · 2y ago

Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons" Now on BioRxiv www.biorxiv.org/content/10.1... Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social

Do you teach neuroscience? Here’s a list I’ve compiled of mostly free online neuroscience textbooks, simulations and datasets you can use for your course! If I’m missing something, let me know so I can add it! docs.google.com/document/d/1...

Free Neuroscience Textbooks and Online Tutorials

Free Neuroscience Textbooks and Online Tutorials (Compiled by Carlos Aizenman, Brown University, Dept. of Neuroscience) Maintaining a current list of digital educational resources is tricky. Softwar...

docs.google.com

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/

Events

Aligning Science Across Parkinson’s (ASAP) aims to foster collaboration and discovery by supporting virtual and in-person events that facilitate connections and provide an avenue for sharing ideas. Se...

parkinsonsroadmap.org

Just going in to lab hoping no one in Congress notices me feeding mice little sweet treats to see if they really want it or just merely like it

Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...

Autophagic stress activates distinct compensatory secretory pathways in neurons

Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...

biorxiv.org

So proud of Adam Fenton and his work defining the role of FMRP in the local regulation of mitochondrial fission in neurons via local translation: www.nature.com/articles/s41...

FMRP regulates MFF translation to locally direct mitochondrial fission in neurons - Nature Cell Biology

Fenton et al. show that FMRP granules dock at the mitochondrial midzone in a Rab7-dependent manner in axons and dendrites, where they promote local MFF synthesis and fission at the mitochondrial midzo...

nature.com

Happy to be here and excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons" Now on BioRxiv www.biorxiv.org/content/10.1... Many thanks to @erikaholzbaur.bsky.social and @asapresearch.bsky.social