A family of small proteins links c-di-GMP riboswitch signaling with sporulation in Clostridioides difficile https://www.biorxiv.org/content/10.64898/2026.06.10.731418v1

New pre-print from the lab! Murepavedin is a Pseudomonas-specific antibiotic, but it disrupts the outer membranes of a wide range of different Gram-negatives. www.biorxiv.org/content/10.6...

Murepavadin is a broad-spectrum outer membrane permeabiliser

Murepavadin is a Pseudomonas-specific antibiotic that targets LPS transport protein LptD. However, whilst the mode of action of murepavadin is well defined, the mechanism by which the drug gains acces...

biorxiv.org

I am very happy to be in the part of this work! Congratulations @abarbotin.bsky.social @carballido-lab.bsky.social journals.asm.org/doi/10.1128/...

Two temperature-dependent membrane fluidity regimes in gram-positive bacteria | mSphere

Temperature changes affect the physical properties of the plasma membrane. Typically, a reduction in temperature causes a less fluid and thus more viscous, membrane. It has been long established that ...

journals.asm.org

D-alanine aminotransferase (Dat) promotes Staphylococcus aureus colonization fitness on human nasal respiratory epithelium https://www.biorxiv.org/content/10.64898/2026.06.01.729472v1

Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase -in #mSystems journals.asm.org/doi/10.1128/...

Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase | mSystems

Mapping the DacA interactome reveals how environmental and intracellular cues tune c-di-AMP signaling to control stress adaptation, ion balance, and virulence traits in Streptococcus mutans. By identi...

journals.asm.org

Latest research from the lab out now. We examined the role and expression of fimbriae during UPEC bloodstream infection. A real team effort and brilliant collaboration with Mark Schembri’s lab in Brisbane. Thanks to the MRC and BBSRC for supporting our research @ukri.org

Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection

Author summary Extraintestinal pathogenic Escherichia coli (ExPEC) colonise the human gut without causing disease but can disseminate to the urinary tract and bloodstream. Understanding the mechanisms...

journals.plos.org

I'm very happy to share that part of my PhD research has published in PLOS Genetics! « FabF and FadM cooperate to recycle fatty acids and rescue ΔplsX lethality in Staphylococcus aureus. » 🥰 Many thanks to all collaborators. journals.plos.org/plosgenetics...

FabF and FadM cooperate to recycle fatty acids and rescue ∆plsX lethality in Staphylococcus aureus

Author summary Phospholipids are vital cell membrane components. The essential Staphylococcus aureus phospholipid synthesis enzyme PlsX uses acyl-ACP, the end-product of fatty acid (FA) synthesis (FAS...

journals.plos.org

Out Now! Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis #MicroSky

Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis

Nature Microbiology, Published online: 26 May 2026; doi:10.1038/s41564-026-02368-6Wall teichoic acids confer rod shape in the Gram-positive model organism Bacillus subtilis by occluding pores in the cell wall, thereby preventing runaway isotropic (non-oriented) peptidoglycan synthesis.

go.nature.com

Purine and pyrimidine analogues differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin resistant Staphylococcus aureus https://www.biorxiv.org/content/10.64898/2026.05.24.727567v1

E. coli ST131 is becoming carbapenem resistant. I suspect as CTX-M moves onto the chromosome and the F plasmid is lost facilitating acquisition of carbapenemase plasmids. No good can come of this

The Lancet Microbe@lancetmicrobe.bsky.social · 4mo ago

New research article Emergence of carbapenemase-producing #Escherichia coli in acute care hospitals in 32 European countries (the CCRE survey) www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #Ecoli #OpenAccess #OA

We have a PhD position in Leiden within our #ERCSyG @microclockerc.bsky.social project to dissect circadian clocks in bacterial biofilms We are looking for candidates with optogenetics, single cell microscopy and image analysis background Application deadline 12 June 2026 👉 edu.nl/cqra3

I'm currently advertising a PhD position in my lab, to study the transition from commensal to pathogen in Staphylococcus aureus. Details available here, please share! www.keele.ac.uk/research/pos...

FacultystudentshipinSchoolofLifeSciences

keele.ac.uk

Super excited to share the final version of our story on how Enterococcus faecalis remodels membrane lipids to protect itself from daptomycin! 🥳 www.pnas.org/doi/10.1073/...

A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin | PNAS

Daptomycin is a last resort antibiotic used to treat vancomycin-resistant enterococcal infections, but daptomycin resistance (DAPR) arises quickly ...

pnas.org

A new weapon against stubborn bacteria: study shows that disrupting two cell-wall pathways at once can overload bacterial metabolism, causing oxidative damage and cell death – even in wall-free L-forms that evade many antibiotics. Via Sydney Mass Spectrometry CRF. Paper 👉 go.nature.com/4tgbBeV

Any postdocs in Microscopy/Microbiology/Host-Pathogen/AMR looking to set up their own labs? Look here: www.uts.edu.au/research/exp... Life in Sydney is pretty darn good! ☀️🏄🏻‍♂️🦘 Reach out for more info.

Chancellor’s Research Fellowships | University of Technology Sydney

Ranked top 100 worldwide and #7 in Australia, UTS offers industry-led degrees in Sydney’s tech precinct with a strong focus on career-ready skills.

uts.edu.au

Adaptation of the freshwater anaerobic methanotroph 'Ca. Methanoperedens vercellensis' to low pH levels reveals membrane lipid remodelling https://www.biorxiv.org/content/10.64898/2026.04.11.717812v1

Big congratulations !🥰🥳

Carballido-López's lab@carballido-lab.bsky.social · 5mo ago

Rut named fellow of the European Academy of Microbiology (EAM)!!! fems-microbiology.org/european-aca...

Rut named fellow of the European Academy of Microbiology (EAM)!!! fems-microbiology.org/european-aca...

European Academy of Microbiology welcomes 95 new Fellows

Discover the latest election of 95 new Fellows by the European Academy of Microbiology, highlighting diverse expertise in the field.

fems-microbiology.org

The fatty acid synthesis pathway is a checkpoint for lipoteichoic acid synthesis in Staphylococcus aureus https://www.biorxiv.org/content/10.64898/2026.04.06.715823v1

Two temperature-dependent membrane fluidity regimes in Gram-positive bacteria https://www.biorxiv.org/content/10.64898/2026.01.22.701129v1

E. coli is the leading bacterium causing death from AMR infections worldwide. If you'd like to explore approaches to exploit the DNA damage response as alternative antimicrobial, please apply to the following PhD studentship available in my lab starting October 2026: www.findaphd.com/phds/project...

Exploiting the bacterial DNA damage response as an alternative antimicrobial at Newcastle University on FindAPhD.com

PhD Project - Exploiting the bacterial DNA damage response as an alternative antimicrobial at Newcastle University, listed on FindAPhD.com

findaphd.com

MPKaDB: A pKa Database for Exploring pH Dependence in Membrane Proteins https://www.biorxiv.org/content/10.1101/2025.11.14.688495v1

A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin https://www.biorxiv.org/content/10.1101/2025.11.16.688641v1

BioPrediction-PPI: Simplifying the Prediction of Protein-Protein Interactions through Artificial Intelligence https://www.biorxiv.org/content/10.1101/2025.11.16.688401v1

🔊 New story! This GlmR (of hope) article has it all. Cell shape, cytokinesis, c-di-AMP, and catalysis - the famous 4 Cs 💎? There is also antibiotic resistance, phosphorylation, acetylation, and a (cool) model to explain what shapes Bacillus cells. Excellent group effort. Congrats team! #Microsky

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 10mo ago

Staying in the loop to make ends meet: roles and regulation of GlmR in Bacillus subtilis https://www.biorxiv.org/content/10.1101/2025.11.05.686802v1

Recruitment of the outer-membrane lipoprotein DolP to thedivision site via cardiolipin-mediated diffusion-stateswitching https://www.biorxiv.org/content/10.1101/2025.10.29.685289v1

Excited to share my latest postdoctoral work in the Shen Lab at Tufts! In this study, we follow up on an exciting finding by former grad student @shailab.bsky.social that C diff uses its Class A PBP (PBP1) to drive cell division (unlike previously studied bacteria)! journals.plos.org/plosgenetics...

Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex

Author summary Bacterial cell division is an ancient and essential process, but our molecular understanding of this process is primarily based on studies in a select few model systems. Recent work fou...

journals.plos.org

📢 We have an open position for a postdoc to join my lab. It's a great position @animecol-uu.bsky.social, fully salaried for 2.5 years with all benefits. www.uu.se/en/about-uu/... The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)

Postdoctoral researcher in molecular ecology - Uppsala University

Postdoctoral researcher in molecular ecology, Department of Ecology and Genetics, Uppsala University

uu.se

#MicrobiologyMonday: Staphylococcus aureus divides by building a septum and then splitting into 2 daughter cells. But how is septum formation coordinated with cell scission? Research in #mBio suggests cell wall mechanical stress could play a role: asm.social/2Eq

Identification of radical SAM enzymes responsible for the methylation and desaturation of archaeal lipids and an AttH hydratase mediating hydroxy-GDGT biosynthesis https://www.biorxiv.org/content/10.1101/2025.10.20.683597v1