Congratulations to @shouyafeng.bsky.social @sethlucianmasters.bsky.social and the entire team on our lab’s latest publication out now in @natimmunol.bsky.social! #autoinflammation #autoinflammatory

Seth Masters@sethlucianmasters.bsky.social · last yr.

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis. rdcu.be/d9iRG

#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review bit.ly/4gLCpOx

Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus - Nature Reviews Rheumatology

This Review provides a comprehensive update on dysregulated type I interferon production and signalling in autoinflammatory interferonopathies, monogenic systemic lupus erythematosus and conditio...

bit.ly

Looks like a great inflammazoom coming up Dec 16 with @inflammasomelab.bsky.social and Si Ming Man! These talks are great for everyone interested in autoinflammation. Register here to access the live session as well as on-demand talks from past sessions: events.abcam.com/AnYVL?rt=Qlp...

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

rdcu.be

Excited to share this paper from my post-doc at @niaidnews.bsky.social out now in Science Immunology! We show that recent or ongoing 🫁 infections or other pulmonary environmental exposures at the time of infection with SARSCoV2 can vastly influence early replication of the virus in mice.

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

science.org

The December issue of #Science #Immunology is out now! This week: #MAITcell plasticity in #antibacterial immunity; how #inflammatory status of #lung before #COVID19 infection impacts #viral control; & #helminths utilize glutamate dehydrogenase to prevent #AAMs & #TH2 activation! bit.ly/SI_DEC_24