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The Inflammasome Lab, led by Prof Kate Schroder at IMB, University of Queensland — uncovering the molecular machines that drive inflammation, and turning that knowledge into new medicines.

inflammasomelab.com

Despite a long history of world-leading discoveries, Australia's science system is going backwards – at the very moment the rest of the world is moving forward, fast. That's why we've launched BACK AUSTRALIA'S ABILITY, a call to every Australian to do exactly that.

#InfectiousDisease #WheelOfFortune - how have I not discovered this game until now? Castle games at Château de Chillon #Switzerland

Fantastic opportunity for a PhD in beautiful Lisbon with the amazing @danielhfisch.bsky.social !

GIMM Institute@gimminstitute.bsky.social · 5mo ago

Apply until May 3rd, 2026 Join GIMM for a PhD in Biology & Biomedicine (Jan 2027). 🧬 We advance research addressing complex biological questions while providing the foundational and professional skills required for multiple career paths. 🔗 gimm.pt/education-an...

📣 Applications Now Open: 2026 ACDS Professional Development Award 📣 (1/6) ACDS members are invited to apply for the 2026 ACDS Professional Development Award, designed to support early-career researchers in taking part in professional development opportunities and advancing their career!

I will start my own research group at @ipblncsic.bsky.social, and I am already available to support fellowship applications!! A dream come true thanks to my mentors' continuous support: J-M Ruysschaert, @ppelegrin.bsky.social, Kate @inflammasomelab.bsky.social, @clarebryant.bsky.social Thank you!

What a fabulous lab motto from lab alumnus, @dave_boucher (Twitter). Dave is all of these things, to the max 😀. Well said, Dave!

Looking forward to @keystonesymposia.bsky.social on Innate Immunity - starts tonight! 🤗🎉

Inflammasome Lab@inflammasomelab.bsky.social · 6mo ago

Poster deadline is approaching for @keystoneSymposia.bsky.social #InnateImmunity: Diversity in #HostDefense & Disease, this March in Banff! See scholarship, abstract and registration: keysym.us/KSInnateImmune26 #KSInnateImmune26 @jkagan1.bsky.social @brozlab.bsky.social

Beyond excited that two of my brilliant students, Kirsten and Manasa, submitted their PhD theses in the last few weeks! Congratulations ladies! The future of science is in great hands. #inflammasomes #PhDone #ProudPI

Poster deadline is approaching for @keystoneSymposia.bsky.social #InnateImmunity: Diversity in #HostDefense & Disease, this March in Banff! See scholarship, abstract and registration: keysym.us/KSInnateImmune26 #KSInnateImmune26 @jkagan1.bsky.social @brozlab.bsky.social

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

keysym.us

It's shaping up to be an amazing line up at the Gordon Cell Death meeting! Register now! www.grc.org/cell-death-c...

#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

sciencedirect.com

💫 You’re invited - our first event of 2026 is just around the corner! 💫 (1/6) 💡Join us for an exciting morning of insightful talks from leading experts and invaluable conversations with members of the cell death community

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...

A fantastic innate immunity conference coming soon. Join us! youtu.be/xmQv36uYm7s?...

Innate Immunity Meeting Promo

YouTube video by KeystoneSymposia

youtu.be

Deadlines are approaching for @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! See key dates: keysym.us/KSInnateImmune26 #KSInnateImmune26

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

keysym.us

Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu! symposia.smart.org.cn/sym/event/Fu...

The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below. Closing date 13th of February. uq.wd3.myworkdayjobs.com/en-GB/uqcare...

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Convergent evolution of scavenger cell development at brain borders - Nature

Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...

nature.com

#ARCschedule Jan26 update ARC announced huge delays & 3-month announcement windows (used to be 2 weeks). Delay in months per scheme: 🔹LP25: 1–4 🔹IC/IH26: 1–4 🔹FT26: 1–3 🔹LP26: 2.5–5.5 🔹LE27: 2–5 🔹DE27: 1.5–4.5 🔹DP27: 3–6 Just … appalling. Unworkable. Data ▶️ docs.google.com/spreadsheets...

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....

Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice

Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.

science.org

Working with a great team to organize @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! Join us to explore emerging research in Banff! keysym.us/KSInnateImmune26 #KSInnateImmune26

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

keysym.us

Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia

What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc! authors.elsevier.com/a/1ly0C3vVUP...

Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology! #Immunology #NatureSMB #Inflammasomes rdcu.be/eG1Nm

Towards a molecular and structural definition of cell death

Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...

rdcu.be

Happy to announce that our paper is finally out! Thanks to @brozlab.bsky.social and co-authors @elliottbernard.bsky.social @ehartenian.bsky.social 🥳 the NLRP6 inflammasome is activated by sterile- or pathogen-induced endolysosomal damage @embojournal.org

Broz Lab@brozlab.bsky.social · 9mo ago

link.springer.com/article/10.1...

Who wants to discuss innate immunity and host defense? Join us in Banff to share your exciting research. www.keystonesymposia.org/conferences/...

Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

keystonesymposia.org

New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story. www.biorxiv.org/content/10.1...

Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling.

The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...

biorxiv.org

Review @cp-molcell.bsky.social @inflammasomelab.bsky.social NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress www.cell.com/molecular-ce...

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw