Our newest paper on fast single-round selection of hyper-modified aptamers from over-represented dually nucleobase-modified DNA libraries has been published in @natcomms.nature.com. @iocbprague.bsky.social doi.org/10.1038/s414...

New article from the lab on HaloTag-based chemical proteomics in RSC Chemical Biology. Simple, fast and highly selective labelling of probe-protein conjugates allow gel-based shift assay and pull-downs followed by MS proteomics. Congratulations @rubaba.bsky.social! pubs.rsc.org/en/content/a...

A cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis

Chemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on a proteome-wide scale. The strategy relies on the reactivity and specificity of bioor...

pubs.rsc.org

New preprint from the lab! Check out how to employ chloroalkane probes in chemical proteomics - in-gel shift assay and mass spectrometry. Fast, fully bioorthogonal and easy to do. Congratulation to the first author @rubaba.bsky.social! www.biorxiv.org/content/10.6...

Cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis.

Chemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on proteome-wide scale. The strategy relies on reactivity and specificity of bioorthogon...

biorxiv.org

✨ A decade of science, collaboration, and innovation – celebrating 10 years of #BayBioMS at @tum.de School of Life Sciences! What an incredible day at the 10-Year Anniversary Symposium 🎉

One gene can code for proteoforms with: ◼️ different functions ◼️ different sequences ◼️ different regulation ◼️ different cell type expression Such examples should inform the interpretation of gene deletion experiments seeking to infer "gene functions".

For those who like this work: There are still 2 weeks left to apply for the PhD position in my group! www.chemzymes.com

Felix Kaspar@chemzymes.bsky.social · 10mo ago

Today @chemrxiv.org we write about two major innovations that facilitate in vitro prenoid and terpenoid analogue biosynthesis. doi.org/10.26434/che... Thread below 👇

I am looking for a PhD student interested in enzymes! For the full annoucement: www.chemzymes.com

What can HaloTag do for you? Triggered fluorogenic labelling? Molecular recording? Photo-Chemically Induced Dimerisation? Philipp Mauker's CHalo motif lets reagents do all three, and more. Read the preprint here - doi.org/10.1101/2025... #chembio #fluorescence #cellbio #SLP

The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social

New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social

LMU remains the best German university www.lmu.de/en/newsroom/...

LMU remains the best German university

In the latest Academic Ranking of World Universities, LMU ranks among the world’s top 50 research-intensive universities.

lmu.de

We are hiring! If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland! More information on www.epfl.ch/labs/gr-schu...

Open positions

GR-SCHUHMACHER

epfl.ch

Great talk by Ronald Micura about Challenges in biological RNA chemistry @lmumuenchen.bsky.social 😀

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration! www.cell.com/cell/fulltex...

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

cell.com

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry. 🙏 RETWEET (We want to recruit internationally) Organic chemistry meets #DirectedEvolution Highly interdisciplinary & passionate research group uni-bielefeld.hr4you.org/job/view/433...

Research Position (PhD) in organic chemistry and b...

<div style="text-align: justify;">The&nbsp; research&nbsp; group&nbsp; „Organic&nbsp; Chemistry&nbsp; and&nb...

uni-bielefeld.hr4you.org

🎉 Nadace Experientia zná stipendisty pro rok 2025! 👨‍🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen. 👨‍🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University. Gratulujeme!

🚀 PhD position at the intersection of medicinal chemistry and chemical biology. You'll develop ferroptosis inhibitors to combat bacterial lung infections 🧪 Research (50%) /🎓 Teaching (50%) Looking for someone with: ➡️ Strong background in organic synthesis ➡️ Passion for working across disciplines

One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last! With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible. doi.org/10.1038/s41592-025-02663-w #KusterLab #WilhelmLab #MSAID #Proteomics

Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods

CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...

doi.org

Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.

Back in July 2023 we organized a small bioML symposium at @iocbprague.bsky.social, and it turned out to be a very pleasant and successful event. This summer we are following up with a great line-up of speakers. Please register for free, deadline May 30. tinyurl.com/bioMLPrague25

Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio

Self-assembled PROTACs enable glycoproteins degradation in the living cells

We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...

pubs.rsc.org

We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards Marina Rubini @mlakemeyer.bsky.social @michellefrei17.bsky.social Hana Macíčková Cahová @drglycoben.bsky.social @borisvauzeilles.bsky.social @stephanhacker2.bsky.social (1/4) #ChemBio #ChemSky

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors. #ABPP #ChemSky #ChemBio

The first chemistry.unwrapped video in the ENERGY series is out 💥🔥 Watch on YouTube in full quality: www.youtube.com/watch?v=OdPT... @chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky

Bread is FULL of Sugar?! 🍞🤯

YouTube video by chemistry.unwrapped

youtube.com

chemistry.unwrapped@chemistryunwrapped.bsky.social · last yr.

Did you know bread is packed with sugar? 🤯 But why doesn’t it taste sweet like gummy bears? 🍬 The answer lies in the science of simple vs. complex carbs! Watch on YouTube in full quality: www.youtube.com/watch?v=OdPT... @michaljuricek.bsky.social #chemsky #pisky

#research #chirality Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/... @iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social

Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...

We are looking for PhD candidates to work in Paris at @sorbonne-universite.fr on synthesis & (photo)catalysis inside cyclodextrins with bimetallic complexes in collaboration with @metallacycle.bsky.social

🥳Congratulations, Matthias Tschöp! 🥂 Following our successful past collaborations in promoting young PIs to tenure-track professorships, we look forward to working with you to shape LMU’s future🤩

LMU München@lmu.de · 2y ago

Herzlichen Glückwunsch, Matthias Tschöp. Der derzeitige CEO des Helmholtz Zentrums München wurde heute zum neuen Präsidenten der LMU gewählt. Seine sechsjährige Amtszeit beginnt am 1. Oktober 2025. www.lmu.de/de/newsroom/...

Bei ihr trifft Fachwissen auf didaktische Kompetenz: Die Studierenden von Prof. Dr. Lena Daumann @daumannl.bsky.social aus der Chemie @hhu.de sind begeistert und haben sie für den #hhuLehrpreis2025 nominiert. 🧪