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Marleen Bérouti

@marleenberouti.bsky.social

Scientist working on Toll-like receptors and nucleases ✂️🧬

3 Posts81 Follower104 Folgt
Tobias Komar@t-komar.bsky.social · last yr.

Excited to share the first paper of my PhD, published in the Journal of Biological Chemistry. Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and @mannlab.bsky.social, and my supervisor @v-hornung.bsky.social. www.jbc.org/article/S002...

Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus

Interleukin-1β (IL-1β) is a pivotal mediator of innate immunity, essential for orchestrating the acute inflammatory response. While the canonical activation of IL-1β involves cleavage of its inactive ...

jbc.org

Gene Center Munich @LMU Munich@genecenter-lmu.bsky.social · last yr.

🥳Amazing publication from the Hornung lab, in collab. with the Carell lab, on the innate immune system: how modified RNA tricks the immune system. Big shout-out to the two first authors, Marleen Bérouti and Mirko Wagner! www.cell.com/cell/fulltex... @v-hornung.bsky.social @m-berouti.bsky.social

Innate immune system: How modified RNA tricks the immune system

Researchers at LMU have elucidated why certain RNA modifications do not trigger an immune response—a key mechanism for RNA therapeutics.

lmu.de

Marleen Bérouti@marleenberouti.bsky.social · last yr.

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration! www.cell.com/cell/fulltex...

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds t...

cell.com

Cell - a Cell Press journal@cp-cell.bsky.social · last yr.

Now online! Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement

Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection. However, modified nucleosides common in self-RNA—most notably pseudouridine—evade recognition. This study finds that poor nuclease processing and selective TLR avoidance drive this evasion, offering insight into the molecular basis of immune tolerance to pseudouridine-containing RNA.

dlvr.it

Gene Center Munich @LMU Munich@genecenter-lmu.bsky.social · last yr.

Wow, so cool!🌟 Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy 🥂🥳🤩 www.lmu.de/en/newsroom/... @v-hornung.bsky.social

NUCLEATE Cluster of Excellence: beacon of nucleic acid research

The new NUCLEATE Cluster of Excellence is all about nucleic acids. The research alliance seeks to better understand their various functions and open up new areas of application.

lmu.de

Rebsamen Lab @UNIL@rebsamenlab.bsky.social · 2y ago

Excited to share our latest paper out today in @naturecomms.bsky.social ! Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #ImmunoSky #InterferoSky

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications

TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...

nature.com