So ready for SIDP/MAD-ID meeting. Nail inspiration credit @klusardi.bsky.social #BSDchat @mmpharmd.bsky.social @ebhirsch.bsky.social @krutikamh.bsky.social @sidpharm.bsky.social @mad-id.bsky.social
Meghan Jeffres
@pharmermeg.bsky.social
ID Pharm, antibiotic allergies, UTIs, MedEd fun & games Podcaster: Medical Rewrites https://tinyurl.com/MedRewrites (Apple) https://tinyurl.com/MedRewrite (Spotify)
This is super exciting. JAK1 inhibitor turns out to be a very effective treatment for TEN/SJS www.nature.com/articles/s41...
nature.com
Hi #IDSky! I’m putting together my usual top 10 ID papers of this year list again (this time will post here not in the other world). Please tell me your candidate papers - practice changing paradigm shifting or dogma challenging!
New paper from my colleagues at UCLH Nearly 70% (!!!) resistance to Cefiderocol in NDM positive bacteria. Cefiderocol...we hardly knew ye... Perfect timing for World Antimicrobial Awareness Week #waaw24 #IDSky academic.oup.com/jac/advance-...
Resistance profiles of carbapenemase-producing Enterobacterales in a large centre in England: are we already losing cefiderocol?
AbstractBackground. Carbapenemase-producing Enterobacterales (CPE) pose difficult therapeutic challenges. We aimed to characterize antimicrobial resistance
academic.oup.com
Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics. 14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell www.sciencedirect.com/science/arti...
Morning #IDSky what is your preferred rounding structure for teaching services? Would love to know why in comments 👇 1️⃣ AM team rounds 2️⃣ PM team rounds 3️⃣ BID team rounds 4️⃣ Keep it flexible 📊 Show results
ID Connections #2 Same game as the NYT Connections but with ID content and unlimited guesses. connections.swellgarfo.com/game/-OBYIEo...
Interesting! SubQ meropenem. “Subcutaneous meropenem appears to be well tolerated and has a favourable pharmacokinetic profile. Either 1.5 g twice daily or 3 g as a 24 h subcutaneous infusion could be considered for future evaluation.” academic.oup.com/jac/advance-...
Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administration
AbstractBackground. Subcutaneous delivery of antibiotics is a practical alternative to IV administration. Meropenem is commonly used to treat infections ca
academic.oup.com
Can we treat patients with low-risk BSI discharged from the ED with a fully-oral course of antibiotics? [Spoiler: Yes!] 🆓🔓Our recent article on #OralIsTheNewIV! 👉🏻 journals.asm.org/doi/10.1128/... Food for thought for #AMSsky #IDSky
Safety of early oral ambulatory treatment of adult patients with bloodstream infections discharged from the emergency department | Antimicrobial Agents and Chemotherapy
Randomized trials have unanimously shown the benefits of oral antibiotic treatments for stable patients with bacteremia (1). However, transition to oral therapy has been usually performed after several days of intravenous treatment—frequently up to 7 days (2)—highlighting the need for evidence of the safety of earlier oral treatments (3).
journals.asm.org
My Top 5 Antibiotic Allergy Papers - #5 ▶️Gadde et al. JAMA 1993; 270 (20) ▶️ A paper before its time. Skin testing for #penicillinallergy in patients with ID indication! ▶️ 7.1% + ; PPL & MDM utilisation; safety (1/128+ required adrenaline); Allergy LOSS WITH TIME. jamanetwork.com/journals/jam...
Clinical Experience With Penicillin Skin Testing in a Large Inner-City STD Clinic
Objective. —To establish (1) the prevalence of positive penicillin skin tests among outpatients with well-defined but variable history of penicillin allergy and (2) the reproducibility, safety, a...
jamanetwork.com
To get hopefully some #peniicillinallergy #drugallergy folk over to 🦋 from X I am going to list my top 5 #antibioticallergy papers of all time - starting tomorrow! Stay tuned 👀
I'm advertising a PhD studentship (open to international students) working on long read pangenome / assembly algorithms in bacteria. Would suit someone with maths/compsci/coding background. Aptitude + interest more important than experience. Details here: www.findaphd.com/phds/project...
New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath on FindAPhD.com
PhD Project - New graph algorithms for analysis of the genomes and pangenomes of bacteria and their mobile elements. at University of Bath, listed on FindAPhD.com
findaphd.com
Here’s pack 2! Still in progress - will update more tomorrow. It’s been a fun day. Love seeing our community rebuild here! Goodnight Bluesky. 🦋💤
Along the lines of what others have started, here's a #SkyRx starter pack - if I'm missing you let me know! go.bsky.app/DTkEEWG
IDSky continues to grow rapidly We are now >300 users, which means we are on a third Starter Pack IDSky Starter Pack 1 go.bsky.app/LnAQjdq IDSky Starter Pack 2 go.bsky.app/JNfSvQT ID Starter Pack 3 go.bsky.app/FeogT7o Check back on the most recent one often as it is updated frequently
Hi friends on #IDSky. Hoping we re-create what we once had on twixter. So here's another old favorite, guaranteed to get your Sunday off to a happy start. (Grrrr ... still mad about this one.) blogs.jwatch.org/hiv-id-obser...
How to Induce Rage in a Doctor
If you’re wondering how to make a doctor angry — really, really angry — read on. Because asking us to justify treatment decisions to insurance companies and their pharmacy benefit managers must rank r...
blogs.jwatch.org
PSA: If you’re ever reversing anticoagulation & someone asks if the patient has had a vasectomy, they’re not being a weirdo. Protamine is made from salmon sperm & post vasectomy patients may have anti sperm antibodies that cross react causing life threatening anaphylaxis!
🔍👁️🍄 “Based on available evidence, and high risk of morbidity of eye involvement, continued ophthalmological screens seem prudent, but a definitive consensus was found to be challenging given a lack of outcome data...” academic.oup.com/ofid/advance... #IDbluesky
Fun ID Pharm Q today Pt on mero 2q8 for ESBL infx and has adenovirus viremia. Starting cidofovor + probenecid = mero dose adjustment 1989 study to the rescue! Mero AUC ⬆️ 55%. T1/2 ⬆️ from 0.9 hr to 1.3 hr. ➡️ 2 Q12 x 48 hrs based on probenecid t1/2 of 5-15 hrs pubmed.ncbi.nlm.nih.gov/2808215/
The pharmacokinetics of meropenem in volunteers - PubMed
Two human volunteer studies were performed with meropenem: a dose proportionality study of 0.25, 0.5 and 1.0 g and a probenecid interaction study. Six volunteers took part in each study. Meropenem was...
pubmed.ncbi.nlm.nih.gov
Looking to build/join the ID peeps I make ID themed games. Obsessed with beta-lactam side chains. New fan of topical estrogen for rUTIs. connections.swellgarfo.com/game/-NuSggy...
