Yes, do attend #Angioscience26 and hear me talk about how #actin and cellular hydraulics control endothelial #mechanobiology during #angiogenesis and #EHT! #zebrafish

Ondine Cleaver@ondinecleaver.bsky.social · 2mo ago

Hear Li-Kun Phng at #Angioscience26! Li-Kun studies endothelial cell behavior during angiogenesis, revealing how cell polarity, migration, and signaling dynamics shape vascular network formation and remodeling in vivo. 🐟 Deadline tomorrow, June 15th! www.vwfb.de/start/regist...

Looking forward to participating in this top-notch meeting!

Ondine Cleaver@ondinecleaver.bsky.social · 2mo ago

Calling all vascular biologists! Join us for cutting edge science at #Angioscience26 in gorgeous Seeon, Bavaria. Awesome speakers, intimate setting, many talks from abstracts. Deadline June 15th to register! vwfb.de/start/regist...

Thank you @navbo.bsky.social for featuring @phnglab.bsky.social as Lab of the Month in May! www.navbo.org/members-labs/

🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...

Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis

Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.

science.org

Latest preprint from @phnglab.bsky.social @riken-bdr.bsky.social ! We show cellular hydraulics as a determinant of hemogenic endothelial cell (HEC) survival during endothelial-to-hematopoietic (EHT) transition. www.biorxiv.org/cgi/content/... #mechanobiology #zebrafish #endothelialcells

Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM. www.bdr.riken.jp/en/news/rese...

When vessel constriction fails: Cellular mechanics linking developmental remodeling to vascular malformations

bdr.riken.jp

Feb 11 is International Day of Women and Girls in Science and at RIKEN BDR, we celebrate the achievements of #womeninscience by holding an IDWGIS Symposium. We also recently launched Mirai Alliance, a mentorship network for women researchers in life sciences. www.bdr.riken.jp/en/news/bdr-...

🚨 SAVE-THE-DATE 🚨 SEEON ANGIOSCIENCE! Fantastic, long-running meeting on Development & Maintenance of the Vasculature. 🗓️ Sept 2026 🌍 Bavaria, Germany Registration open! Join us! vwfb.de/start/regist...

Simply delighted to end the year with the acceptance of Yan’s paper www.nature.com/articles/s41.... It was a heroic effort on her part, and many thanks to all our collaborators for their help! @vizcie.bsky.social @juliaeckert.bsky.social

🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists. In @nature.com doi.org/10.1038/s415...

Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature

Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.

doi.org

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

@sameerthukral.bsky.social · 11mo ago

Excited to share our new review in Development, Growth and Differentiation(DGD) Journall! With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales. Read the full review: onlinelibrary.wiley.com/doi/full/10....

Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!

Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues, an important step towards understanding left-right symmetry in tissues and organs. buff.ly/2pSf3xS

Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

A fantastic week at the Mechanobiology Conference in Vietnam, filled with fascinating talks, fruitful discussions, and amazing people. Huge thanks to the organizers and ICISE for making it all possible!

Thanks to the generosity of #FujiharaFoundation and the excellent organization of Fumio Motegi and his team, the ' #Mechanics of Life Across Scales' symposium was held successfully at beautiful Awaji. We had 3 days of fantastic #mechanobiology talks with speakers from Japan, India, Europe and US.

Had the absolute pleasure of hosting the Leducq ReVAMP biannual meeting @riken-bdr.bsky.social in Kobe this spring! #endothelial #mechanobiology #vascularmalformations See you all again in Fall @ondinecleaver.bsky.social @mvikkula.bsky.social

Check us out @the-node.bsky.social !

the Node@the-node.bsky.social · last yr.

Lab Meeting with the Phng Lab Meet the lab of @phnglab.bsky.social, based @riken-bdr.bsky.social, Kobe, Japan. The lab is interested in vascular #morphogenesis, in particular, endothelial cell mechanobiology in #zebrafish 🐟 Find out more about the lab and what it's like working at RIKEN BDR:

📢 Mechanobiology Conference III: From Fundamental Research to Applications 📅 July 06-12 📍 ICISE Quy Nhon, central Vietnam The registration and abstract submission is now open! 🔗 icisequynhon.com/conferences/...

Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study! Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node

Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.

thenode.biologists.com

Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...

At #RIKEN BDR, women represent 10% of PIs, 31% of researchers, 38% of students and 74% of technical staff. On #IDWGIS last month, we celebrated their achievements and contributions to research at BDR. www.bdr.riken.jp/en/news/bdr-... #internationalwomensday

Careers in Science—Perspectives of Women Researchers and Technical Staff

bdr.riken.jp

Zebrafish study reveals that, along with actin polymerisation, hydrostatic pressure underlies the push of endothelial tip cells into new territory 📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social ➡️: bpod.org.uk/archive/2025...

Chuffed to find out that our work was featured as an Insight article in @elife.bsky.social elifesciences.org/articles/106.... Thank you Sean Sun and colleague for highlighting our work!

Morphogenesis: Fluid transport comes to the fore

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.

elifesciences.org

Proteins that allow water to move in and out of cells help shape the development of new blood vessels. buff.ly/41n6ii0

What an honor to host @itaiyanai.bsky.social at RIKEN-BDR, Kobe! From learning Night Science creativity, to see them come alive with Day Science rigor, Itai truly demonstrated the "yes, and" attitude in person! Thank you for your great energy, passion and generosity! Can't wait to have you back!

Read the Research Highlight here! www.riken.jp/en/news_pubs... @RIKEN BDR

Water gives cells a push in blood vessel formation

RIKEN researchers have shown that that hydrostatic pressure is one of two mechanisms that control endothelial cell migration during angiogenic sprouting in zebrafish

riken.jp

Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formati...

doi.org

Excited to host @itaiyanai.bsky.social at RIKEN BDR, Kobe over the next few days! Looking forward to learning about "Tails" and how to use Night Science "Tales" to supercharge creativity in science! Thank you Itai for accepting our invitation!

Excited to announce that we will be holding another #mechanobiology across scales symposium this year in beautiful Awaji Island #Japan! We have a star-studded lineup of speakers and it's free participation (free accommodation and food!)! Register here: www.igm.hokudai.ac.jp/85th-fujihar...