🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...

Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis

Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.

science.org

Check out our latest preprint on the cellular mechanical basis of Voronoi tessellations in epithelia! This biophysics study is inspired by disordered tessellations observed in zebrafish hearts 🤓🐟💙 #SulaimaanLim #ChiuFanLeeLab arxiv.org/html/2512.13...

🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.

🔬For 22 years, we have been organizing #Mifobio "Functional Microscopy for Biology" the @cnrs.fr thematic school. 🎓 Courses, Seminars, Round Tables, Workshops. The overall theme concerns #biological_imaging in its most interdisciplinary aspects. 👉 Program: imabio-cnrs.fr #GDRImaBio #Mifobio2025

Out @natcomms.nature.com: our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀 Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!). Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social rdcu.be/eIJm5

The pericardium forms as a distinct structure during heart formation - Nature Communications

The developing heart integrates several progenitor cell types. Here they show that the pericardium enveloping the heart develops among cells that form the mesothelium around inner organs and body cavities, distinct from the classic heart field.

nature.com

Christian Mosimann@chrmosimann.bsky.social · 2y ago

New preprint - unravelling the origins of the mesothelium around the❤️: the pericardium! 🎈 SPIM, scRNA-seq, AFM, #CHD, rats & #zebrafish, all rolled into one. Led by our grad student Hannah Moran, a collab with the Sucharov & Peña labs, CU Anschutz - congrats all! #devbio biorxiv.org/content/10.1...

Back from the London Zebrafish Research Network — a truly inspiring afternoon. Many thanks to @cvagenapantoula.bsky.social, @kkalyviotis.bsky.social and Eleni for putting together such an interactive programme, full of excellent talks - Tim 👏 - and great discussions. Zebbie research at its best!

New publication | Science Advances www.science.org/doi/10.1126/...

Plasticity of ventricle position after heart looping in heterotaxy with right isomerism

The left/right position of ventricles needs to be maintained after heart looping, an unexpected step affected in heterotaxy.

science.org

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social More info below ⬇️

Development@dev-journal.bsky.social · 11mo ago

📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells Guest Editors: Alex Hughes and Rashmi Priya 📅 Deadline: 1 March 2026 journals.biologists.com/dev/pages/ex... #DevBio

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 11mo ago

We’re looking for a #postdoc to join Lori Passmore’s group, within a programme aimed at understanding addition of mRNA poly(A) tails More info: www.nature.com/naturecareer... Closes 06 OCT #ScienceJobs #PostdocJobs

How do cells navigate up gradients of adhesive proteins? 🤔 Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood We show that passive friction directs cells & explains complex trajectories on gradients 👉 www.nature.com/articles/s41...

Deadline to register for Get Into Grad School Webinar approaching! Share with interested #undergraduates and #postbacs Registration Deadline: Thursday, September 18. bit.ly/3HFJ9BG

Society for Developmental Biology@socdevbio.bsky.social · 11mo ago

#Undergraduates #Postbacs @socdevbio.bsky.social is hosting a webinar Get Into Grad School September 21 at 3pm ET. Learn about doctoral programs, the key elements of a compelling grad school application, and the interview process. Register: bit.ly/3HFJ9BG

Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️

🚨 Two weeks left to apply for the EMBL-EBI–Sanger Postdoctoral (ESPOD) Programme. Apply by: 30 September 2025. Ready to take the next step in your science career? www.ebi.ac.uk/research/pos... @sangerinstitute.bsky.social #postdoc #sciencecareers

.@ahxanjaved.bsky.social, @sarawickstrom.bsky.social & team discover that Piezo1 balances membrane & cortex tension to stabilize intercellular junctions & maintain the epithelial barrier. journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/... #OpenAccess

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob. www.biorxiv.org/content/10.1...

The complex microscopic dynamics of cells in high-density epithelial tissues

Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...

biorxiv.org

OK--fluorescent protein friends. We want an antibody to TagRFP that works in immunofluorescence. Any suggestions? Re-post please

The first paper of our lab is finally out, and I feel very proud and grateful to our wonderful team! @Jannik Rothkegel, @Sylvia Kaufmann, @Michaela Wilsch-Braueninger, @Catarina Lopes <3 onlinelibrary.wiley.com/doi/10.1002/...

Purine Molecular Interactions Determine Anisotropic Shape of Zebrafish Biogenic Crystals

Many organisms self-organize crystals for vision, pigmentation, or storage. In zebrafish, iridophores produce anisotropic crystals in iridosomes. Using imaging and genetic tools, crystal growth is sh...

onlinelibrary.wiley.com

🧬🔬🧪 🎉 Our team at @czbiohub is thrilled to share TWO companion papers out today in @NatureMethods! 📦 Ultrack — robust, scalable nD cell tracking 🌐 inTRACKtive — a beautiful, open-source web viewer for lineage exploration Let’s dive in! 👇 www.nature.com/articles/s41... www.nature.com/articles/s41...

Happy to see our work, led by @ivanbassi.bsky.social, out today in @jem.org! #Zebrafish help us find new treatments for a #rare_disease affecting #lymphatic vessels! Congrats to all authors and thanks to #MDBRide4Rare, #ODC_UPenn, @erc.europa.eu for support @weizmanninstitute.bsky.social

Journal of Experimental Medicine@jem.org · 12mo ago

Bassi et al. @karinayaniv.bsky.social @weizmanninstitute.bsky.social use #zebrafish to help identify new treatments for a severe lymphatic malformation. rupress.org/jem/article/... #CardiovascularBiology #HumanDiseaseGenetics

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

Call for 20 Assistant Professor positions

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

ki.se

Join junior group leaders using #Drosophila to understand development, #CellBiology, #evolution and more at the EMBO Workshop on Molecular and Developmental Biology of Drosophila, 21–27 June 2026 in Kolymbari, Greece. Deadline: 3 November meetings.embo.org/event/26-dro... #EMBOevents #GeneSky 🧪

Molecular and Developmental Biology of Drosophila

The principal theme of the EMBO Workshop is the Molecular and Developmental Biology of Drosophila. Supported by EMBO over four decades, this will be the 24th biennial “Crete meeting”. With the a…

meetings.embo.org

🇬🇧 We are #hiring a Financial Assistant to join our admin team at Physics of Life! Do you thrive in an international environment and speak both English and German? We would love to hear from you! Apply and learn more here: tud.link/rywtux 🗓️Application deadline: 21st August #financejobs #dresden

Physics of Life Dresden@poldresden.bsky.social · 12mo ago

🚨 #WeAreHiring! Leite das gerne an deine Kollegen weiter! Wir suchen eine/n Projektassistent/in für unser internationales Team bei Physics of Life! Bewerbt euch bis zum 21. August. Mehr Infos hier: tud.link/rywtux #joboffer #jobalert #jobdestages #sachsenjobs #dresdenjobs

🚨 We’re hiring. The Roman group study how cells communicate to keep organs healthy – and how this goes wrong in disease & ageing. Level A (Postdoc) | Clayton campus Apply by 8 Sept: careers.pageuppeople.com/513/cw/en/jo...

Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study! Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node

Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.

thenode.biologists.com

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum. First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social rdcu.be/ezBl7

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

rdcu.be

Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...

Out now! Our very first paper@crick.ac.uk, an impressive feat by @tobyandrews.bsky.social where we show how a developing heart grows and scales up its morphological complexity to keep beating...an excellent summary below ⬇️ www.cell.com/developmenta...

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

cell.com

Toby Andrews@tobyandrews.bsky.social · 12mo ago

Thrilled to bits to see our latest work online in Dev Cell! 🥳 We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n tinyurl.com/cell-stretch