🔬 Lund University (@lund-university.bsky.social) is hiring 3 Assistant Professors in cancer immunotherapy, immunotechnology & immune cell engineering! ✅ Start-up package | tenure track | world-class infrastructure 📅 Deadlines: 26 May & 10 June 2026 🎥 youtu.be/z-PQU9qknZc Apply links 👇

Lund University programme for excellence – three positions within Immunotherapy

YouTube video by Lund University

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Lund University is recruiting a tenure-track Assistant Professor in Experimental Cancer Immunotherapy, and we want the best in the world to apply 🫵 The position comes with a clear path to tenure and an attractive start-up package. Apply or share with outstanding candidates by 10. June. 🔗 in replies

New paper out from the @kpietraslab.bsky.social lab. I am happy to share that my first-author paper is now published. We map the spatial and temporal dynamics of cancer-associated fibroblasts in breast cancer using integrated spatial proteomics and transcriptomics. link.springer.com/article/10.1...

Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancer - Breast Cancer Research

Breast Cancer Research - Cancer-associated fibroblasts (CAFs) are the main constituents of the tumor microenvironment. Several studies have delineated CAF heterogeneity in different types of...

link.springer.com

📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...

Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenc...

Glioblastomas initially respond to radiotherapy but invariably recur, often within high-dose radiation treatment fields. Although stromal radiation responses are incompletely understood, evidence sugg...

biorxiv.org

Check this out👇 Our neighbors @pietraslab.bsky.social has just published a new preprint detailing high-resolution profiling of the irradiated GBM microenvironment. ❄️Cool reading for the holidays❄️ Thanks for including us!

Alexander Pietras Lab@pietraslab.bsky.social · 8mo ago

📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...

📣 PREPRINT ALERT! Glioblastoma (GBM) often responds to radiotherapy, yet almost always recurs, frequently within high-dose radiation fields. www.biorxiv.org/content/10.6...

Coevolution of neoplastic and non-neoplastic reactive astrocyte states converges on mesenchymal-like and injury-response programs during murine glioblastoma progression and post-radiotherapy recurrenc...

Glioblastomas initially respond to radiotherapy but invariably recur, often within high-dose radiation treatment fields. Although stromal radiation responses are incompletely understood, evidence sugg...

biorxiv.org

New paper alert 🚨 We are delighted to present our latest paper in @natcomms.nature.com through fabulous work from co-first authors Sebastian Braun and Paulina Bolivar! Big thanks to all expert collaborators for taking this long journey with us! Tweetorial in comments 🧵 www.nature.com/articles/s41...

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications

Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...

nature.com

Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications

Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...

nature.com

Really excited to see this new paper from our friends & neighbors in the other Pietras lab @kpietraslab.bsky.social, uncovering surprising (?) roles of pericytes in the GBM microenvironment. Congrats all, and thanks for including us! www.nature.com/articles/s41...

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma - Nature Communications

Improved understanding of the tumor ecosystem in glioblastoma is critical for developing new treatment strategies for the disease. Here, the authors identify pericytes as an active paracrine signaling...

nature.com

Excited to share I’ve received a #SSMF #Consolidator grant! 📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics 🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM Interested? Apply now 👇 rb.gy/m7xz7b

Postdoctoral Researcher in "Cancer Neuroscience: the impact of neural activity on 3D genome organization and cellular plasticity in glioblastoma”

rb.gy

How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle. aacrjournals.org/cancerdiscov...

Had a blast hosting the Brain Tumor Plasticity symposium at the Royal Swedish Academy of Sciences this week! Here's @leilaakkari.bsky.social with an outstanding talk on the evolving brain tumor microenvironment 🤩

Thrilled to share our latest work - we describe a novel and therapeutically relevant mechanism underlying dysregulation of innate immune receptor C5aR1 in the tumour microenvironment. Thanks and congratulations to all authors! www.nature.com/articles/s41...

To this day, even the strongest treatments fail when the brain’s own healing turns against it. Flunarizine, a migraine drug, may help stop astrocytes from nurturing #glioblastoma back to life. Read ⤵️

Alexander Pietras Lab@pietraslab.bsky.social · last yr.

📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵: www.biorxiv.org/content/10.1...

📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵: www.biorxiv.org/content/10.1...

Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma

Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...

biorxiv.org

Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma https://www.biorxiv.org/content/10.1101/2025.07.12.664538v1

📣 Preprint alert! Happy to share our latest work, in which we identify Flunarizine as an inhibitor of astrocyte reactivity with therapeutic potential in glioblastoma (GBM). Details in 🧵: www.biorxiv.org/content/10.1...

Phenotypic Screening Identifies Flunarizine as an Inhibitor of Radiotherapy-Induced Astrocyte Reactivity with Therapeutic Potential in Glioblastoma

Radiotherapy is part of the standard-of-care for glioblastoma, yet tumors invariably recur as incurable lesions post-treatment. Recent studies suggest that radiation-induced astrocyte reactivity foste...

biorxiv.org

🌍 Join us in a supportive, international lab within a vibrant cancer research hub! Strong local bioinformatics community + a high quality of life in the Malmö/Lund region. Great science, great people, great place to live. 💻🧬🏡

📣 New pre-print from the lab: 👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM 📝 Read the #BioRxiv here: doi.org/10.1101/2025...

🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...

Doctoral Student in Tumor Biology

Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo

lu.varbi.com

🚨 We’re hiring a bioinformatics-focused PhD student for our ERC-funded project on recurrent GBM! Focus: tumor-supportive microenvironment 🔬 Experience with scRNA-seq, spatial transcriptomics & Python/R a plus. Must be self-motivated & driven. DM for details! Repost=❤️ lu.varbi.com/en/what:job/...

Doctoral Student in Tumor Biology

Description of the workplace The research group conducts experimental research on brain tumors and is led by Associate Professor Alexander Pietras. The group consists of a bioinformatician, two postdo

lu.varbi.com

Just a few spots left for this exciting symposium on brain tumor plasticity—grab yours (free of charge!) before they're gone! 🚨

Silvia Remeseiro Lab@remeseiro-lab.bsky.social · last yr.

🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity 🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social Few spots available. Register here: ui.ungpd.com/Events/ed387...

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Spencer S Watson@drspencerwatson.bsky.social · last yr.

Great to see this paper finally out. We've been using it for a while, a really great resource for omics in glioblastoma! doi.org/10.1093/neuo...

👋We have 2 amazing projects: A) basic molecular regulation of the LN lymphatic vasculature & B) lymphatic metastasis with new models & human samples describing completely new phenomena - both projects with solid preliminary data to build on. Open for interested postdoctoral scientists 📩

Join us for innovative explorations of the tumor microenvironment🔬 Learn cutting-edge technologies and grow in a dynamic environment💡 The postdoc will work alongside a doctoral student from @adaptmet.bsky.social, gaining access to collaborative partners across 🇪🇺. Apply now👇 tinyurl.com/4mby45hf

Postdoc in Experimental Oncology - Lund (Stad), Skåne (SE) job with Lund University | 12838990

Lunds universitet, 009999 LUNDS UNIVERSITET, 310000 MED Lund University was founded in 1666 and is repeatedly ranked among the world’s top universi...

tinyurl.com

I'm delighted to host @ggargiul.bsky.social for a talk in the LUCC seminar series today. Medicon Village Auditorium @ 1.30 - you don't want to miss out if you're in Lund! Welcome!

Hot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...

Ectoderm barcoding reveals neural and cochlear compartmentalization

Placodes and the neural crest are defining features of vertebrates. In this study, we investigate their lineages in mice using in utero approaches. We demonstrated that nanoinjection at embryonic day ...

doi.org

📣 Online now! Our study shows how recurrent focal deletions constitute a mechanism by which cancer cells can dampen toxicity due to gene amplification. www.cell.com/cell-genomic... 🧵👇:

Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...

cell.com

Huge congrats to @kpietraslab.bsky.social on this well-deserved recognition! 🙌🥳

Kristian Pietras lab@kpietraslab.bsky.social · last yr.

We are proud to share that our PI has been named Cancer Researcher of the Year by @Cancerfonden! This well-deserved recognition highlights not only his outstanding contributions to cancer research but also his creativity in tackling scientific challenges and his inspiring leadership within our team.

"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!

Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature

Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...

doi.org