I'm attending online event about a #NIH competition to develop a data-sharing index (S-Index), but am surprised that there aren't more people here (it's hybrid). www.nei.nih.gov/sindex Nice idea for NIH to have a competition for developing a S-index; we've just heard about the winners. 1/n

9/11 This case shows how, with complex data from large surveys, small errors in distance treatment or distortions can produce apparently significant signals. Science works exactly like this: strong claims are checked and, if necessary, corrected.

Many of us profs are struggling w/ AI use by students. But a source of frustration I didn't anticipate: AI use by colleagues. Because if I had wanted an AI’s opinion, I too can prompt ChatGPT 🙄 More in my reflection on "Artificial Intelligence among University Professors" jean.fan/2026/07/16/a...

Very good piece by @tuuliel.bsky.social @nevillesanjana.bsky.social @singht.bsky.social & colleagues: “Current challenges in GWAS integration and fine-mapping for variant interpretation” 🧪🧬 www.biorxiv.org/content/10.6...

Current challenges in GWAS integration and fine-mapping for variant interpretation

Over the past two decades, genome-wide association studies (GWAS) have identified thousands of trait- and disease-associated loci. However, the mechanistic understanding of these loci remains incomple...

biorxiv.org

As a Gilliam Fellow, it’s great to see @hhmi-science.bsky.social continue pushing toward evaluating science on its scientific merit rather than the prestige of the journal it’s in. The future of science should be open, accessible, and focused on the quality of the work, not the name on the cover.

I've pivoted quite hard, changing fields entirely. Based on my experience: - New field is difficult to publish in (you don't speak the "language") - New work gets cited a lot less (lack of networks) - Hard to find a job/tenure (you lack formal qualifications in new field – huge hurdle!) Cont'd...

Jessica Hullman@jessicahullman.bsky.social · last mo.

Lol, a paper that describes my life. My natural reaction to feeling like I'm finally getting the hang of something has always been to drop it and try something else. And somehow I still often feel like I'm not getting out fast enough.

"IF is a flawed metric...not an indication of the quality of published research...But, we are not naive. We know IF influences authors' decisions about where to publish". ☝️ The dilemma every journal faces. And that last sentence is a huge understatement. 1/2 journals.biologists.com/dev/article/...

The elephant in the room: impact factor

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

journals.biologists.com

There's so much to say about this, but what is particularly striking is that the keynote speaker said absolutely nothing about using Claude to write his academic work until I intervened in the Q&A. It appears that he was not going to share this fairly important detail unless asked..

UMAPs have become the ultimate get out of jail free card if you want to say whatever fits your narrative. You want to claim no changes: overlay few colors, or way too many colors. You want to claim a change, circle a zone of the plot, scream that there is a difference. No one will bat an eye.

Did you know that you can use the #easystats #rstats {modelbased} package detect missed modeling by adding partial residuals to your plots? Check out the vignette on plotting options that shows you how to check your model: easystats.github.io/modelbased/a...

Rstudio has a neat feature that when you open a document and some libraries are not installed, there's a banner asking you if you want to install, which triggers a background job installing missing packages. AFAIK this works for CRAN packages. Is there a way to extend it to bioconductor? #rstats

Let's Streisand-effect these people. Here's the editorial that somehow merited calling the cops. Read and share.

Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!

The opinions expressed in this editorial are the personal views of the authors (S.E. Kahn, C.A.M. Anderson, J.B. Buse, and E. Selvin) and do not represent

diabetesjournals.org

Carl T. Bergstrom@carlbergstrom.com · 2mo ago

Remember the current NIH director going on about protecting researchers from government censorship? Today his people called the police in to forcibly remove my colleagues from their own society meeting for sharing an editorial published in their flagship journal that was critical of him. Gift link

Did you recently update your #rstats to 4.6? Is your matrix algebra slow? Not #BLAS ting? `sessionInfo()` shows which BLAS library R uses. Switching from reference BLAS to Apple Accelerate is easily a 50x speedup. Let me know if this worked for you. 🚀 uatz.org/blog/2026-06-04-r-blas-macos/ #rstats

The Lurking Dangers of the R Version Update – ulrich atz

After you update on macOS, switch R to Apple’s fast BLAS for a 50x speedup.

uatz.org

The mythology of academia - noble pursuit of knowledge for knowledge's sake etc - is used by administrators to convince academics who think they don't have a real job to do things against their own self interest. The sooner we realize we *are* workers - with employers - the better.

I uploaded a picture of a random root vegetable and asked ChatGPT to identify it. It told me it was a stochastic carrot.

SNL’s Tucker Carlson is so good, this has been my mental reaction these last weeks every time I see some non sense research practice

Also #singlecell RNaseq for sure 🧪🧬💻

Mattan S. Ben-Shachar@mattansb.msbstats.info · 2mo ago

Psychologists doing clustering be like: #statsmeme

Have a relaxing weekend, everyone who went to Cannes! #stats

Steve Quake quotes Brenner at #cshsymposium2026 : “biology is drowning in a sea of data and starving for knowledge”, arguing that never has this been more apt than now.

A survey of 2600 Ph.D. students, postdocs, and other researchers in 65 countries found that top three complaints were that supervisors: 1) used dismissive communication 2) provided little feedback 3) ignored team members’ well-being The main thing they wanted was empathy

When there’s a meeting and the first presenter is full python matplotlib, and the second presenter is full #rstats ggplot viz. I always feel like

Zoolander Staring Contest: Ben Stiller & Owen Wilson

ALT: Zoolander Staring Contest: Ben Stiller & Owen Wilson

static.klipy.com

🚀 Big updates are here! A new round of #rstats #easystats releases is now live on CRAN, featuring major performance boosts and new features for parameters, bayestestR, performance, modelbased, and see. Update via CRAN or grab the latest dev versions with: `easystats::install_latest()`

Same if you only use animal models but put the human disease term in the title

Fred Armisen: Right To Jail

ALT: Fred Armisen: Right To Jail

static.klipy.com

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

"a paper today is a Frankensteined-together patchwork of supplementary files that run longer than the manuscript, datasets in repositories...code posted to GitHub without documentation. The paper has been replaced....by a mess" www.thetransmitter.org/from-bench-t...

Is the scientific paper due to be replaced?

AI is pushing scientific publishing to the brink. For neuroscience, the crisis may be an opportunity to finally connect findings across subfields.

thetransmitter.org

tinyurl.com/reuxynmc Very excited to see this work I was a small part of published! We analysed two large scale colocalisation datasets: OpenTargets data and an analysis of immune-mediated disease GWAS/immune cell eQTLs seeking to understand the "colocalisation gap". Some highlights:

Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation

Author summary Most of the genetic variants associated with complex traits are located outside genes, limiting functional interpretation. Genetic colocalisation helps identify candidate causal genes b...

journals.plos.org

A flaw in Person-Δ may be overstating progress in single-cell perturbation prediction models. Pearson warned about this in the 19th century: reusing the same controls induces spurious correlation. Split the controls, and much of the claimed prediction power fades: www.biorxiv.org/content/10.6...

New #tidyomics blog post! 🎉 #tidySummarizedExperiment greatly simplifies your omics workflows, giving tidyverse capabilities. We have improved its performance 30x on large datasets with tens of thousands of samples! tidyomics.github.io/tidyomicsBlo... Plz share! @mpibiochem.bsky.social

Speeding up tidySummarizedExperiment through query optimisation and the plyxp backend – tidyomicsBlog

Performance optimisation of tidySummarizedExperiment and related benchmark.

tidyomics.github.io

The normative fraud that Errington describes is something I've seen my whole career. A biologist once told me, if p is very small, it can't be a false positive. Teams condition on null being false, see anything that makes p small as truth-seeking. These traditions spread bc they get you published.

Randy Ellis@randalljellis.bsky.social · 3mo ago

SHOCKING stories of data fabrication Tim Errington shares a never-before-told story of data fabrication in cancer biology. Scientists go to extreme measures, even engaging in data fabrication, to secure a publication in prestigious journals. #science #truth #medicine #stem #shorts