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Louise Marston

@proflouisemarston.bsky.social

Professor of Clinical Trials Statistics at Priment Clinical Trials Unit, UCL. England rugby fan, Trailfinders Women. Often out taking photographs.

102 Posts111 Follower 69 Folgt

Louise Marston @proflouisemarston.bsky.social · 2w ago

ENHANCE (Tailored Intervention for Brain Health and Cognitive Enrichment for Cognitive Health), a Coach-Supported Digital Intervention for Dementia Prevention in Underserved Older Adults: Co-Design and Usability Study www.jmir.org/2026/1/e91999 @ucl-primarycare.bsky.social @jmirpub.bsky.social

jmir.org

Louise Marston @proflouisemarston.bsky.social · last mo.

Comorbidities and Complications in Parkinson’s Disease in Primary Care onlinelibrary.wiley.com/doi/10.1111/... @ucl-primarycare.bsky.social

Comorbidities and Complications in Parkinson’s Disease in Primary Care

Many comorbidities are increased in PD. However, they are not associated with greater mortality than in controls, and are not sufficient to explain the increased mortality in PD.

onlinelibrary.wiley.com

Louise Marston @proflouisemarston.bsky.social · 3mo ago

Prevalence of mental disorders in people with intellectual disabilities across the lifespan: umbrella review in BJPych Open www.cambridge.org/core/journal... @proflikahass.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

Prevalence of mental disorders in people with intellectual disabilities across the lifespan: umbrella review
J Santambrogio, G Boido, M Marchetti, S Rudra, F Besana, E Francia,
S Terrevazzi, D Papola, C Barbui, M Bertelli, M Clerici, A D’Agostino,
L Marston, A Hassiotis

Background
People with intellectual disabilities experience higher rates of
mental disorders, contributing to restrictive practices and
premature mortality. Prevalence data are essential to understanding
the patterns of disease, and for the development of
tailored interventions.
Aims
To systematically examine the burden and pattern of mental
disorders in people with intellectual disabilities across the
lifespan.
Method
We searched six databases (inception to 17 October 2024), and
conducted a manual search up to 15 December 2024, for
systematic reviews on the prevalence of mental disorders in
people with intellectual disabilities with or without neurodevelopmental
conditions. We conducted a narrative synthesis
of prevalence rates, including those stratified by intellectual
disability level, sex, age and autism, where available, and
compared these with published prevalence rates in people
without intellectual disabilities (International Prospective
Register of Systematic Reviews, no. CRD42024610611).
Results
We included 26 systematic reviews: 7 meta-analyses and 19
narrative reviews. Compared with the general population, the
prevalence of schizophrenia (3.55–4.80%), anxiety (5.4–5.5%) and
obsessive–compulsive disorders (2.4%) appeared higher,
whereas that of mood (6–7%), personality and post-traumatic
stress disorders appeared lower. Study quality was moderate to critically low. For syndromic intellectual disabilities we noted
high anxiety rates in fragile-X, Williams and 22q11.2 deletion
syndromes, and in those with co-occurring autism. We found
gaps on dementia, bipolar, substance use and eating disorders,
and limited data stratified by intellectual disability level, sex
and age.
Conclusions
This um…

Louise Marston @proflouisemarston.bsky.social · 3mo ago

Persistent health inequalities over 20 years among adults with intellectual disabilities who display behaviours that challenge: evidence from English primary care records www.cambridge.org/core/journal... @proflikahass.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

UCL Centre for Ageing Population Studies @ucl-caps.bsky.social · 3mo ago

🏡We’re pleased to share the synopsis from the “HomeHealth" trial, funded by NIHR This report summarises findings on the clinical- effectiveness and cost-effectiveness of a home-based health promotion intervention to support independence in older people with mild frailty. 📰Read the synopsis below!

journalslibrary.nihr.ac.uk

Louise Marston @proflouisemarston.bsky.social · 3mo ago

@ucl-primarycare.bsky.social

UCL Faculty of Brain Sciences@uclbrainscience.bsky.social · 3mo ago

One in 10 times that a person with dementia goes missing results in serious harm, finds a new @uclpsychiatry.bsky.social led analysis of police data on missing people incidents involving older adults in the UK. www.ucl.ac.uk/news/2026/ma...

Louise Marston @proflouisemarston.bsky.social · 4mo ago

@ucl.ac.uk is 200! It was also quiet and sunny this morning when I was there.

UCL 200th anniversary stone in the ground

UCL Portico with 200th anniversary banners.

UCL Department of Statistical Science @statisticsucl.bsky.social · 5mo ago

Boost your skills in #MedicalStatistics with the popular Practical Statistics for Medical Research (PSMR) short course at UCL. This popular course offers hands-on training for #health researchers. #Biostatistics #ClinicalResearch #shortcourse Details: www.ucl.ac.uk/mathematical...

Practical Statistics for Medical Research

Advance your career with Practical Statistics for Medical Research at UCL Statistical Sciences. Expert-led training in biostatistics, clinical data analysis, and evidence-based research methods.

ucl.ac.uk

UCL Institute of Epidemiology and Health Care @ucliehc.bsky.social · 6mo ago

NIHR School of Primary Care Research (SPCR) #PhDStudentship opportunity at UCL 📣 Applications are invited from individuals with a strong academic record who wish to develop a career in primary care research. Deadline: Monday 23rd March at 12pm. www.spcr.nihr.ac.uk/career-devel...

SPCR Studentships in Primary Health Care

spcr.nihr.ac.uk

Louise Marston @proflouisemarston.bsky.social · 6mo ago

@rbgkew.bsky.social had a public involvement panel for #KewOrchids! www.flickr.com/photos/louis...

Kew did PPI for its Kew Orchids 2026!

flickr.com

UCL primary care and population health @ucl-primarycare.bsky.social · 7mo ago

🚀 NIHR SPCR PhD Studentships now open at UCL PCPH! We’re inviting applications from outstanding candidates interested in developing a career in primary care research. 📅 Start: October 2026 More info: PCPH research: www.ucl.ac.uk/population-h... SPCR studentships: www.spcr.nihr.ac.uk/career-devel...

Research

Our programme of internationally competitive research addresses the management and prevention of disease in high-priority areas of health.

ucl.ac.uk

UCL primary care and population health @ucl-primarycare.bsky.social · 7mo ago

📢 PhD Studentship Opportunity at UCL Interested in AI, NLP, and health? We’re recruiting a PhD student for TRUST: Transparent, Responsible, User-centred Sexual-health Technologies using NLP Open to home& overseas applicants Deadline: Mon 26 Jan 2026 www.postgraduatestudentships.co.uk/opportunity/...

PhD Studentship Opportunity: TRUST: Transparent, Responsible, User-centred Sexual-health Technologies using Natural Language Processing - Opportunities at UCL 93352

Find out more from about PhD Studentship Opportunity: TRUST: Transparent, Responsible, User-centred Sexual-health Technologies using Natural Language Processing at UCL at Postgraduate Studentships and...

postgraduatestudentships.co.uk

Louise Marston @proflouisemarston.bsky.social · 9mo ago

Validated self-administered screening tools to identify depression among young adults (18 to 25-years-old) in East Asia and the Pacific Region low-and-middle income countries (LMICs): A systematic review by my PhD student Dennis Dantic. https//www.science... @ucl-primarycare.bsky.social

tools for symptoms of depression among young adults (18 to 25 years old) in East Asia and the Pacific. A total of
22 studies with 24,069 participants were included, covering both clinical and non-clinical populations. Nine selfadministered
screening tools were identified, with Patient Health Questionnaire-9 (PHQ-9), Patient Health
Questionnaire-2 PHQ-2, and Centre for Epidemiological Studies Depression (CES-D) being the most frequently
studied. PHQ-9 demonstrated moderate to excellent internal consistency reliability, with Cronbach’s alpha
ranging from 0.67 to 0.92, and a pooled AUC of 0.86, indicating strong screening accuracy. PHQ-2, showed an
Area Under the Curve (AUC) of 0.85, high sensitivity (0.96), and moderate specificity (0.80). CES-D exhibited an
AUC of 0.87, good sensitivity (0.81), and specificity (0.78), with high heterogeneity (I² = 74.70 %–86.69 %). The
meta-analysis revealed substantial variability in sensitivity and specificity across settings, with differences in
study methodologies, cutoff scores, and reference standards contributing to high heterogeneity. Additionally,
95.5 % of studies had a moderate risk of bias in patient selection, affecting generalizability. Despite these limitations,
PHQ-9, PHQ-2, and CES-D remain valuable tools for identifying symptoms of depression among young
adults. The accessibility, ease of administration, and strong psychometric properties of these tests support their
continued use in resource-limited settings, though standardization of methodologies and expanded regional
validation are needed to improve screening accuracy and applicability.

UCL primary care and population health @ucl-primarycare.bsky.social · 9mo ago

🎉 Big congrats to Tas Rookes for passing her PhD viva with flying colours! 🧠 Thesis: Improving engagement in health promotion for older adults with mild cognitive impairment 👏 Supervised by Professor Kate Walters, Louise Marston, Rachael Frost, Megan Armstrong & Yolanda Barrado-Martín

a picture of a graduation cap and tassel with the words congrats you did it

ALT: a picture of a graduation cap and tassel with the words congrats you did it

media.tenor.com

UCL Innovative Clinical Trials Unit @innovative-ctu.bsky.social · 10mo ago

We're excited to share our latest work on estimands in clinical trials! 📄 Estimating treatment effects in trials with outcome data truncated by death: A case study on aligning estimators with estimands. 🔗 Read the full paper: journals.sagepub.com/doi/10.1177/...

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

Justin C Yang (楊溢)@justinyang.me · 10mo ago

Apply to work with me and a great team at @uclpsychiatry.bsky.social to do some exciting research using electronic health records! The position is funded for 19 months in the first instance and you’ll be joining a fascinating NIHR project: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

Louise Marston @proflouisemarston.bsky.social · 10mo ago

Evidence for health promotion interventions to improve cognitive and physical functioning outcomes in older adults with MCI: A state-of-the-art review www.sciencedirect.com/science/arti... @ucl-caps.bsky.social @ucl-primarycare.bsky.social @drmegs.bsky.social @tasminrookes.bsky.social

Background
Health promotion activities for people with mild cognitive impairment (MCI) may improve their overall health and prevent progression to dementia. We need to understand the best approaches to behaviour change in this population.
Aim
To summarise the types of health promotion interventions and current clinical effectiveness evidence for physical and cognitive functioning outcomes in people with MCI.
Design
State-of-the art review
Method
Medline was searched in April 2025, for systematic reviews synthesising randomised controlled trials testing effectiveness of health promotion interventions in older adults with MCI, published since 2015. Abstracts, titles, and full texts were single screened and, for eligible reviews, the characteristics, intervention type, primary outcome, and evidence for people with MCI, were extracted. Key messages were narratively synthesised across reviews, grouping by type of intervention and outcome measure.
Results
From 1776 titles and abstracts, 57 systematic reviews were eligible. Regular moderate intensity multicomponent physical exercise and memory-focussed cognitive training interventions had the strongest evidence base for improving cognitive functioning. However, combining physical exercise and cognitive training was more beneficial for cognitive domains and physical functioning, in comparison to doing them individually. The evidence for nutrition interventions was mixed. One review of psychological interventions showed improvements for wellbeing.
Conclusion
There is evidence that health promotion interventions can support people with MCI and dementia to improve or maintain their cognitive function, through multicomponent physical activity combined with cognitive training. More evidence is needed for nutritional recommendations, psychological interventions, and social inclusion interventions.

UCL primary care and population health @ucl-primarycare.bsky.social · 11mo ago

📢 New Publication Alert Congratulations to @Roganie Govender and the entire team on their latest publication! A fantastic achievement! @ucl-primarycare.bsky.social bmjopen.bmj.com/content/15/9...

Swallowing prehabilitation for people with head and neck cancer: a pilot cluster-randomised feasibility trial of the SIP SMART intervention

Objectives To assess the feasibility of delivering the swallowing prehabilitation intervention known as Swallowing Intervention Package: Self-Monitoring, Assessment and Rehabilitation Training (SIP SM...

bmjopen.bmj.com

UK CTU Network @ukctunetwork.org · 11mo ago

Every data point tells a story. Statisticians ensure those stories are heard—spotting safety concerns, reducing bias, and ensuring ethical outcomes in clinical trials. 🔗 ukcrc-ctu.org.uk #Statistics #UKCTUNetwork #WorldPatientSafetyDay2025

UCL primary care and population health @ucl-primarycare.bsky.social · 12mo ago

📢 New dataset drop! The BRHS @ucl-brhs.bsky.social is now available via @ukdataservice.bsky.social 🎉 🔗 ukdataservice.ac.uk 7,735 men tracked over 50 years = goldmine for research on heart health, ageing & behaviour. Prof. Wannamethee: “Unparalleled insights into ageing & heart health.”

JAMA @jama.com · last yr.

📌 The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research. ja.ma/4fzMVZS

Figure. SPIRIT 2025 Diagram of the Schedule of Enrollment, Interventions, and Assessments

Louise Marston @proflouisemarston.bsky.social · last yr.

Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT NIHR report out today www.journalslibrary.nihr.ac.uk/hta/MKAC9495 @nihr.bsky.social @ucl-primarycare.bsky.social @gnielsenphysio.bsky.social @jonstoneneuro.bsky.social

Louise Marston @proflouisemarston.bsky.social · last yr.

Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial @nihr.bsky.social report out today. @ucl-primarycare.bsky.social www.journalslibrary.nihr.ac.uk/hta/GJPS6321

Front page of the MePFAC HTA report with abstract.

UCL Institute of Epidemiology and Health Care @ucliehc.bsky.social · last yr.

Want to help shape national dementia prevention strategies? We're looking for a Research Assistant on the PRACTICAL study ▶️ www.ucl.ac.uk/work-at-ucl/... Closing date: 13 Jul 2025 @ucl-primarycare.bsky.social

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

UCL primary care and population health @ucl-primarycare.bsky.social · last yr.

🎉 Huge congratulations to our PhD candidate, Dennis Emaralino, for successfully passing his PhD upgrade last week! His project, Anxiety, Depression, and Mental Wellbeing Among Young Adults in the Philippines. Very well done! 👏

UCL Institute of Epidemiology and Health Care @ucliehc.bsky.social · last yr.

We're excited to advertise a permanent role as a Clinical Lecturer in Primary Care (0.6FTE) in our Institute for a GP holding a PhD or equivalent qualification who would like to develop a career as an academic in research and education. Click here for more details: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk

Prof Paola Zaninotto @profpaolazaninotto.bsky.social · last yr.

What a great PhD Research day we had at the UCL IEHC! Poster presentations and 3min thesis completion! Well done everyone 👏👏👏👏

JAMA @jama.com · last yr.

The CONSORT and SPIRIT statements for randomized trials have been updated for 2025 and published in JAMA, with a new focus on open science principles and guidance on trial registration, data access, and conflict of interest reporting. ➡ CONSORT 2025: ja.ma/3Yyu0Hh ➡ SPIRIT 2025: ja.ma/3YjFfn8

Gary Collins @gscollins.bsky.social · last yr.

NEW PAPER: Updated CONSORT-2025 for reporting randomised trials is now available in the @bmj.com @jama.com , @thelancet.bsky.social, @plos.org and @naturemedicine.bsky.social —> www.bmj.com/content/389/... #openscience #transparency #medsky #statssky #episky

Louise Marston @proflouisemarston.bsky.social · last yr.

The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders doi.org/10.1192/bjp.... @joannamoncrieff.bsky.social @soniajohnson1.bsky.social @ucl-primarycare.bsky.social @uclpsychiatry.bsky.social

Abstract from BJPsych for paper: The association between relapse and the outcome of schizophrenia and recurrent psychotic disorders.