The NIH-funded PRIMED (Polygenic Risk Methods Development) Consortium was launched in 2021 and is working to address gaps noted in this recent @nytimes.com article www.nytimes.com/2026/07/20/s...

This Lifesaving Genetics Tool Works Best if You’re White

Genetic prediction models are poised to revolutionize medicine. But because they have been trained on European DNA, they threaten to widen health care disparities.

nytimes.com

Watch @prsmethods.bsky.social investigators Dave Conti and Sara Cromer present on "Incorporating Polygenic Risk Scores and Social Determinants of Health Across Populations" from the May @ajhgnews.bsky.social journal club, now added to our PRIMED video collection: primedconsortium.org/education#en...

🎉 Congratulations to @prsmethods.bsky.social investigators on this work on developing genetic risk scores for type 2 diabetes in diverse ancestry populations

Josep Mercader@josepmercader.bsky.social · 2mo ago

I am very excited to see this paper out, which has been an Herculean effort, led by @aliciahuerta.bsky.social and Joohyum Kim and co-supervised by Maggie Ng and myself, now published in the The Lancet Group (Lancet Diabetes & Endocrinology) www.thelancet.com/journals/lan...

🎉 Congratulations to @prsmethods.bsky.social investigators on this manuscript advancing contextualization of genetic risk 🧬

Mike Inouye@mikeinouye.bsky.social · 2mo ago

Contextualizing the Utility of Polygenic Risk Scores using Absolute Risk Models in Diverse Ancestry Populations www.medrxiv.org/content/10.6... I don't think Nilanjan is on bluesky so cross-posting his preprint (and linkedin summary) here: www.linkedin.com/posts/nilanj...

👋 Come work on our new ELSI (Ethical, Legal, and Social Implications) R01 grant focused on cloud-based platforms and their promise to ‘democratize’ the genomic data sciences ☁️ 🧬 wd5.myworkdaysite.com/recruiting/u...

🗓️ Join @prsmethods.bsky.social investigators on May 13 to discuss integrating Social Determinants of Health (SDoH) and polygenic risk scores 👀 Event information: bit.ly/4chGKtr 🔖 Publication: pubmed.ncbi.nlm.nih.gov/41785862/

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · 4mo ago

The authors take the mic. In this upcoming May 13 Journal Club Webinar, @ajhgnews.bsky.social’s paper authors Sara J Cromer, MD, MS, and David Conti, PhD, unpack what it takes to integrate PRS and SDoH across genetically and socially varied populations—LIVE: https://bit.ly/4chGKtr #ASHG

👀🧬🫀 ICYMI - updated data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org! anvilproject.org/releases/202... 1/

The authors of the @ajhgnews.bsky.social latest article explore the opportunities and challenges of harmonizing data across cohorts & biobanks & outline key ethical considerations for conducting or reporting this work: https://bit.ly/4dbA3JZ #ASHG @prsmethods.bsky.social

Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research

Despite increasing focus on the intersection of genetic and social risk factors on health, heterogeneity in how these factors are measured, distributed, and analyzed across populations and datasets co...

bit.ly

Are you interested in understanding how social and structural determinants of health influence estimates of genetic risk? Looking for figures for teaching these concepts? Check out our work on considerations for modeling them together, led by Sara Cromer and Dave Conti with @prsmethods.bsky.social

The American Journal of Human Genetics@ajhgnews.bsky.social · 5mo ago

🧬 New Review from Cromer et al! 📄 Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research #PRS #SDoH

The @prsmethods.bsky.social consortium - in 5 years, going from "Can we predict disease genetically" to "Can we predict disease in a way that's accurate, equitable, and clinically useful across diverse populations?" Find out more at primedconsortium.org/research/hig...

The call for #DNADay26 essays is out! Open to students in grades 9-12 📝 🧬 Pro tip for genetics professionals: the contest is also often looking for judges...

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · 7mo ago

The #DNADay26 Essay Contest is HERE! 🧬This year’s challenge: Analyze a genetic treatment or therapy developed or widely used in recent years. Teachers—help your students share their ideas with the world! Submit by March 4 👉 https://www.ashg.org/dna-day/ #ASHG

PRIMED Year in Review: Join us as we look back on some of what @prsmethods.bsky.social consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/

🧬🫀🌏 NEW data release from the OurHealth study of Cardiovascular Disease in South Asians now available on @anvilproject.org! anvilproject.org/news/2025/11... 1/

📢 New from the @prsmethods.bsky.social consortium, "Recommendations for responsible use of population descriptors in polygenic risk score development"! H/t to leads @johannalsmith.bsky.social and Quan Sun www.nature.com/articles/s41... in @natgenet.nature.com

Recommendations for responsible use of population descriptors in polygenic risk score development - Nature Genetics

In this Perspective, authors from the Polygenic Risk Methods Development (PRIMED) Consortium highlight the ethical and analytical impact of population descriptors in polygenic risk score development a...

nature.com

🎉 Congrats to Julie-Alexia Dias and thanks for the shout out to @prsmethods.bsky.social ! "Some of the most formative parts of my own training have come from working across groups and institutions...through my involvement in PRIMED (Polygenic Risk Methods Development)..."

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · 10mo ago

@ajhgnews.bsky.social sat with Julie-Alexia Dias, MSc, in the latest "Inside AJHG" to discuss her recently published paper, “Evaluating multi-ancestry genome-wide association methods: statistical power, population structure, and practical implications.”➡️ ashg.org/ajhg/inside-... #ASHG #humangenetics

👀 🔖 ICYMI @prsmethods.bsky.social investigators report on incorporating social determinants of health into disease prediction in the NIH All of Us research program - www.medrxiv.org/content/10.1...

Quantifying Social Determinants of Health for Disease Prediction: A Multi-Level Approach Using Healthy People 2030 and All of Us Data

Despite the growing recognition that social determinants of health (SDoH) play a prominent role in shaping health outcomes, inconsistent measures across health systems and research studies - and the a...

medrxiv.org

Attending #ASHG25? Learn how @prsmethods.bsky.social investigators are improving polygenic risk prediction in diverse populations by visiting these talks and posters docs.google.com/spreadsheets...

ASHG 2025 PRIMED Abstracts

docs.google.com

👀🔖 Check out this new review by @prsmethods.bsky.social member Iftikhar Kullo, which explores the current state of the field, highlights key challenges, and outlines future directions for the use of PRSs to improve risk prediction and to advance personalized prevention in clinical care

Nature Reviews Genetics@natrevgenet.nature.com · 10mo ago

New online! Clinical use of polygenic risk scores: current status, barriers and future directions

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

medrxiv.org

‪The PRIMED Consortium has a new handle: @prsmethods.bsky.social! Please tag us there when referencing our work or to share with us the latest in PRS methods development. We’re excited to keep connecting with you!

👀 🔖 Congrats to @aliciahuerta.bsky.social @josepmercader.bsky.social and @prsdiversity.bsky.social co-authors and collaborators on this pre-print demonstrating that multi-ancestry PRSs improve T2D prediction across all ancestries www.medrxiv.org/content/10.1...

Josep Mercader@josepmercader.bsky.social · 12mo ago

Sharing a global effort to develop PRSs for T2D in multiple ancestries. www.medrxiv.org/content/10.1... funded by NHGRI @prsdiversity.bsky.social #D_PRISM Collab with Maggie Ng, with Tian Ge, Alisa Manning, Marie Loh, Piper Below, Xueling Sim, led by star @aliciahuerta.bsky.social and Joohyun Kim

📣 Reminder that @anvilproject.org is calling all genomic researchers, data scientists, and cloud computing enthusiasts to register for the AnVIL Community Conference In-person registration closes Aug 19: https:/bit.ly/anvil2025

NHGRI AnVIL@anvilproject.org · 12mo ago

⏳ Only 1 Week Left to Register for ACC2025! Register before August 19 to come to Nashville on Sep 3–5! bit.ly/anvil2025 🔵 Full (in-person): $75 🔵 Student (in-person): $25 🔵 Virtual: free And don't forget to submit an abstract for a poster or talk by this Friday, August 15! bit.ly/acc2025-abst...

Thanks to @elsihub.bsky.social for featuring "A data model for population descriptors in genomic research" from the NIH-funded @prsdiversity.bsky.social consortium in their "New Publications" section! www.cell.com/ajhg/abstrac... elsihub.org/news-and-eve...

🚨 Registration is OPEN for #AnVILCommunity2025 Conference! Join us in Nashville, Sept 3-5 for talks, posters, & CoFest! - Regular rate ($75): bit.ly/acc2025-register - Student rate ($25): bit.ly/acc2025-register-student - Virtual (free!): bit.ly/acc2025-register-virtual Don’t miss it!

🎉 Out now in @ajhgnews.bsky.social: the @prsdiversity.bsky.social perspective on data sharing to improve genetic risk prediction in global populations 🧬🌎 🌍🌏 See also our thread on the pre-print - bsky.app/profile/prsd...

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · last yr.

Data sharing is crucial to advancing health research. @ajhgnews.bsky.social's latest article provides policy recommendations to facilitate future use & sharing of heterogeneous data sources w/ a goal of improving polygenic risk prediction: www.cell.com/ajhg/abstrac... @prsdiversity.bsky.social

ICYMI - see this recent work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social introducing a data model for population descriptors in genomic research 🎉 published in @ajhgnews.bsky.social www.cell.com/ajhg/abstrac...

Sarah Nelson@blueyedgenes.bsky.social · last yr.

👀 🧬 Curious how to respectfully, robustly, and flexibly use population descriptors in genomic research, and align with @nationalacademies.org recommendations? Check out this work from the NIH-funded PRIMED Consortium @prsdiversity.bsky.social, co-led by Alyna Khan and Stephanie Gogarten

Happy #DNADay25 from the PRIMED Consortium @prsdiversity.bsky.social! Genetic information can help improve risk prediction for a broad range of health outcomes. Learn more: 🧬 Publications: primedconsortium.org/publications... 🧬 Research Highlights: primedconsortium.org/research/hig...

American Society of Human Genetics (ASHG)@geneticssociety.bsky.social · last yr.

🎉Happy #DNADay!🧬Today we celebrate the amazing impact of genetics on science, health & society by answering your questions on AI + genetic testing. Plus, we're celebrating our #DNADay25 Essay Contest winners at noon! 🏆👏 Join the convo here: redd.it/1k7i3t1 #ASHG #HumanGenetics

I wrote a thing. I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach. Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

Nature@nature.com · last yr.

Scientists must push back against the threat of rising white nationalism and the dangerous and pseudoscientific ideas of eugenics https://go.nature.com/4jGqiUc

👀 🔖 🧬 New @prsdiversity.bsky.social publication out in @ajhgnews.bsky.social, "Opportunities and challenges of local ancestry in genetic association analyses" 1/ www.sciencedirect.com/science/arti...

Opportunities and challenges of local ancestry in genetic association analyses

Recently, admixed populations make up an increasing percentage of the US and global populations, and the admixture is not uniform over space or time o…

sciencedirect.com

I'm delighted to be part of this symposium, put on by University of Pennsylvania Perelman School of Medicine, and led by @bpasaniuc.bsky.social and @sarahtishkoff.bsky.social. See you in a few weeks! upenn.co1.qualtrics.com/jfe/form/SV_...