FITdb, a one-stop shop for immune functional genomics so you can query, browse, and analyze your favorite genes and pathways across multiple contexts in mouse and human immune cells. #immunefunction visit fitdb.lji.org

FITdb, an Integrated Functional Immunogenomics and Transcriptomics Database

Genetic screens in immune cells enable the systematic interrogation of gene function at scale, uncovering key regulators of cell functions such as tumor cell killing and persistence. However, existing...

biorxiv.org

IH is proud to support the 2026 AAI ASPIRE award recipients and introduce their contributions to immunology through a special collection. Read more from Anna Globig, Pamela Rosato, Jenna Guthmiller, Brandon Dekrosky, and @reinacampos.bsky.social: academic.oup.com/immunohorizo...

Review @reinacampos.bsky.social Spatial instruction of tissue immunity Open Access academic.oup.com/immunohorizo...

It’s so helpful to see thoughtful engagement with these issues.

todd gureckis@toddgureckis.bsky.social · 7mo ago

draft lab ai policy, feel free to use, modify, or discuss! todd.gureckislab.org/2026/03/06/g...

This was a lovely read

Carl T. Bergstrom@carlbergstrom.com · 8mo ago

1. I’m quite happy with this popular piece that Lee Dugatkin and I wrote recently. For the next two weeks it’s free to read on the American Scientist website.

Had this been a 42-nucleotide ribozyme… Seriously impressive nonetheless, never thought this was possible.

Di Jiang@dijiang319.bsky.social · 8mo ago

@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution

Abstract submission and registration just opened 🤫 #spatial #biology

SanDiegoing #paraglider #blacksbeach

FITdb keeps growing with new #functionalscreens and viz features, now including human screen comparisons and figure-ready plot downloads. We are currently crunching the biggest perturb-seq dataset yet… stay tuned!

Kickstarting the 2026 Reina Lab retreat with a good dose of #nightscience courtesy of Dr. Wayne Beach, an expert (human) Conversation Analyst, under the premise - can we leverage human interaction analysis frameworks to think outside the box in cellular communication? … food for thought

www.statnews.com/2026/01/10/n...

The NIH has lost its scientific integrity. So we left

“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

statnews.com

The beneficial effects of vaccines in lowering dementia risk are bigger, better established, and occur for a wider range of vaccines than I had realized. Flu, tdap vax as well as shingles. Gift link: www.nytimes.com/2026/01/03/h...

Vaccines Are Helping Older People More Than We Knew

nytimes.com

I’ve been mentoring admissions + fellowship applications for ~6 years (through Científico Latino, Project SHORT, TechDev Academy, and as an NSF mentor via Harvard GSAS), and I finally formalized it into a clear coaching structure with options + pricing. www.yaelcourtney.com/coaching

Hill shenanigans 🎄 #paragliding

-16!! We made it out of Boston alive… jokes aside it was awesome seeing the students get a chance to share their progress in front of a fantastic crowd. #Immgenmaps

How could I miss this study earlier this year? This is wild, so cool. Cell-autonomous innate immunity by proteasome-derived defence peptides

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature

Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

nature.com

Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...

TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods

TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

nature.com

Major new release of spatial data today - Take a peek using our #ImmGenMaps Portal or go for a deeper dive using #talktodata powered by BioTuring. New additions include bone marrow, adipose tissue (three different kinds), bladder…

#CancerImmuno speaker list is live!📢 Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research. Early Bird Deadline: 15 Jan 2026 👉 Click here to register: bit.ly/4qZVqmd #FusionImmunology #FusionCancerResearch

@larallbb.bsky.social and colleagues from @salkinstitute.bsky.social report a new #aging paradigm that links systemic infections and aging with astroctyte-dependent control of motor skills in mouse and humans. www.biorxiv.org/content/10.1...

The antiviral Interferon pathway drives astrocyte aging and motor decline

Aging encompasses low-level inflammation and motor decline. Astrocytes are neuroregulatory glial cells that change in aging, particularly in the cerebellum, which is essential for movement coordinatio...

biorxiv.org

According to the Colorectal Cancer Alliance, more than 50,000 people in the United States will die from colorectal #cancer this year. LJI Assistant Prof. Miguel Reina-Campos (@reinacampos.bsky.social) hopes to help change that statistic. bit.ly/3LJfvwK #CancerResearch #Immunology #Health #Medicine

LJI Assistant Professor Miguel Reina-Campos wins funding to accelerate treatments for metastatic colorectal cancer

LJI scientists team up with Colorectal Cancer Alliance's Project Cure CRC to end this devastating cancer

lji.org

Finally got to visit the birthplace of spatial biology to meet my heroes pushing the field at @ki.se, lovely campus full of wicked smart trainees - thanks for the invite @ejvillablanca.bsky.social

Eduardo Villablanca@ejvillablanca.bsky.social · 11mo ago

Packed room for @reinacampos.bsky.social’s talk at @cmm @ki.se! Miguel presented stunning insights into how spatial cues instruct T cells in tissue barriers. Cutting-edge and deeply inspiring research!

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

If Kathy Nguyen is ever your eye surgeon, you’ll be in good hands! This brilliant undergrad spent her summer training in LJI's Reina Lab (@reinacampos.bsky.social). Now she's poised to pursue a career in medical science: www.lji.org/blog/a-pivot... #SanDiego #medicine @ucsandiego.bsky.social

A pivotal summer of science

Donor-supported internship program brings talented students to LJI labs

lji.org

Maps have powered human discovery for centuries. At @immgen.bsky.social, we are creating the first spatial omics atlas of the mouse immune system **ImmGenMaps** to help connect the dots. Powered by Bioturing, we are now making these data available to all. Happy Exploring!

ImmGen’s Spatial Omics Portal - Talk2Data by BioTuring

Discover Talk2Data – a BioTuring project offering tutorials, interactive tools, and curated content for biology learners and researchers.

talk2data.bioturing.com

If you think I'm not alarmed, read this. www.theatlantic.com/newsletters/...

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. www.nature.com/articles/s41...

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications

This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

nature.com

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

cell.com

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is SMC (structural maintenance of chromosomes) protein 1A! 🧬🛠️ Our cell lines & plasmids are available for just the cost of shipping to reduce the barriers to scientific discovery. 📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social

#Spatialtranscriptomics breakthrough with RAEFISH - Impressive work

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.

cell.com