Nat. Biotech. Brief. on our hybrid solid-liq optics work rdcu.be/fpLtj rdcu.be/fnktk Much thanks to Jan Huisken for expert opinion: "The HySIL concept represents a genuine advance..The authors tackle a notable limitation in the field: achieving submicrometer resolution over centimeter-scale volumes"

Affordable centimeter-scale 3D microscopy with submicrometer resolution

Nature Biotechnology - Submicrometer-resolution three-dimensional (3D) imaging of large samples has been constrained by the short working distance, high cost and inflexible design of immersion...

rdcu.be

www.youtube.com/watch?v=3-gR...

Imaging Breakthroughs Could Change How we View Cells

YouTube video by Photonics Media

youtube.com

HySIL / pLSM-SCOPE / SLICE work out now in Nature Biotechnology (open article)!

Nature Biotechnology@natbiotech.nature.com · 3mo ago

Hybrid solid−liquid optics enable scalable, high-resolution light-sheet microscopy across diverse immersion media - @rtomer.bsky.social @columbiauniversity.bsky.social go.nature.com/4xdDkQR

@rtomer.bsky.social : Pizza time at AQLM! @aqlm.bsky.social !

Are we born as a blank slate, or with a neural “operating system”? We show hippocampal neurons self-organize into memory-like networks in a dish. We also introduce IncStim, a compact, all-optical sys. for closed-loop act. imaging/manipulation inside an incubator. www.biorxiv.org/content/10.6...

In vitro reconstitution of hippocampal cell assemblies

Three-dimensional neuronal cultures, such as brain organoids, have proven effective for in vitro modeling of brain development and disease. However, it remains unclear whether these systems can intrin...

biorxiv.org

Sharing new work from us+collaborators. We take a step toward making organ-scale, subcellular 3D imaging as scalable & affordable as next-gen sequencing, to eventually fuel next-gen of AI-foundational models of tissues, organs. www.biorxiv.org/content/10.1... Videos: www.youtube.com/playlist?lis...

Scalable, affordable, submicron 3D imaging of multi-centimeter scale samples. - YouTube

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy. Authors: Cheng Gong, Pauline Affatato, Matt Fay, Sudha R...

youtube.com

A milestone worth reflecting on - 1000 citations for our cleared tissue light sheet paper - the COLM. Gratifying that core ideas have stood the test of time and are broadly adopted: Cuvette-based sample mounting; Virtual slit effect with rolling shutter CMOS; and Linear adaptive offset correction!

Love this!! I don’t think I’ve ever seen anything like this before -- high-res light sheet microscopes designated for use by individual researchers in one lab!! Fantastic to see real-world impact emerging, starting with Bianca’s lab at JLG, Columbia!

MBF Bioscience@mbfbioscience.bsky.social · last yr.

✨ Exciting news! SLICE™, our award-winning light sheet microscope, is now up and running at the Marlin Lab at Columbia University @columbiauniversity.bsky.social, ready to power advanced 3D imaging and accelerate discovery. Here’s to more breakthroughs ahead! 🚀🔬 #3DImaging #ResearchInnovation

We’re proud to work with Dr. Tomer & his team at Columbia University to bring SLICE to life, a compact, affordable light-sheet microscope making 3D imaging more accessible worldwide. 📖 magazine.columbia.edu/article/3d-i... @rtomer.bsky.social @columbiauniversity.bsky.social #SLICE #lightsheet

3D Imaging Just Got Easier

Columbia researchers have developed a powerful new microscope that could enable more scientists around the world to conduct cutting-edge biomedical research.

magazine.columbia.edu

We had to join the trend. Introducing: Jack Glaser, Founder and President of MBF Bioscience —now an action figure. Complete with microscope, field journal, and trusty lab dog. 🧠🐕 In science, there are no small people—just big ideas. #ScienceMatters #STEM #Microscopy

Our digital times :-)

Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue journals.plos.org/plosbiology/...

have ppl found any funders that support toolmaking? I want to keep making tools for people, but there is a seemingly irresistible force pushing us towards hypothesis-driven research. In my experience, funders don't want to hear about tech dev. Any insights? for both neuro & climate would be great tx

Delighted to highlight our new paper in @natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...

Synaptic basis of feature selectivity in hippocampal neurons - Nature

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

nature.com