Our June issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope. Paper here: www.nature.com/articles/s41...
Gokul Upadhyayula
@supgokul.bsky.social
Asst Prof of Molecular and Cell Biology, UC Berkeley Scientific Director, Advanced Bioimaging Center
Dubbed a “Swiss army knife” for biological imaging, MOSAIC’s development was led by Biohub Investigator @supgokul.bsky.social of @ucberkeleyofficial.bsky.social . Learn more about the microscope, and the “AI mind” he’s creating to make sense of all the data ⤵️
Hi-res microscopes give biologists petabytes of data. Scientists are creating an AI assistant to make sense of it. - Berkeley News
At UC Berkeley, high-resolution microscopes are generating images of cells and embryos day and night, collecting massive amounts of data to train an AI model for living biological systems.
news.berkeley.edu
Nature Methods@natmethods.nature.com · 3mo agoMOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @supgokul.bsky.social www.nature.com/articles/s41...
Exciting work from MCB's Eric Betzig, Gokul Upadhyayula @supgokul.bsky.social & collaborators at UCB's Advanced Bioimaging Center! 🔬 news.berkeley.edu/2026/05/22/h...
Hi-res microscopes give biologists petabytes of data. Scientists are creating an AI assistant to make sense of it. - Berkeley News
At UC Berkeley, high-resolution microscopes are generating images of cells and embryos day and night, collecting massive amounts of data to train an AI model for living biological systems.
news.berkeley.edu
The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods
MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...
nature.com
MOSAIC: a versatile multimodal microscopy that seamlessly transitions between light-sheet, 2-photon, label-free and super-resolution modalities. @supgokul.bsky.social www.nature.com/articles/s41...
A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods
MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...
nature.com
We are recruiting an instrumentation scientist. aprecruit.berkeley.edu/JPF05253
Assistant/Associate/Full Project Scientist - Instrumentation Microscopy – Advanced Bioimaging Center – Department of Molecular and Cell Biology
University of California, Berkeley is hiring. Apply now!
aprecruit.berkeley.edu
🔬🔦Check out our ‘Imaging spotlight’ on Volumetric Imaging via Photochemical Sectioning (VIPS) from @ruixuan3.bsky.social, Srigokul Upadhyayula and colleagues. VIPS helps researchers scale super resolution imaging to large whole-mount tissues. focalplane.biologists.com/2025/12/02/i...
Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - FocalPlane
Imaging spotlight: Volumetric Imaging via Photochemical Sectioning (VIPS) - Tools
focalplane.biologists.com
(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning
Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...
science.org
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → mapped axons & myelin across two mouse olfactory bulbs (WT vs NPC1).
Adaptive optical vision Fourier transformer (AOViFT): a machine learning framework for inferring image aberrations and restoring diffraction-limited performance. www.nature.com/articles/s41...
Fourier-based three-dimensional multistage transformer for aberration correction in multicellular specimens - Nature Methods
Adaptive optical vision Fourier transformer (AOViFT) is a machine learning-based framework for accurately inferring aberrations and restoring diffraction-limited performance in diverse biological specimens.
nature.com
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. MOSAIC captures everything from subcellular dynamics to neural activity in live mice. www.biorxiv.org/content/10.1...
A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms https://www.biorxiv.org/content/10.1101/2025.06.02.657494v1