For the 12th year in a row, @smidtheart.bsky.social has been ranked #1 in California for Cardiology, Heart, and Vascular Surgery by @usnews.com! www.cedars-sinai.org/newsroom/ced...
Russell Rogers, Ph.D.
@russellrogers.bsky.social
Associate Professor, @SmidtHeart.bsky.social Regenerative biology of heart and skeletal muscle. Lab Website: https://www.cedars-sinai.edu/health-sciences-university/research/labs/rogers.html Views are my own.
Pleased to share our paper: #EVs released from #heart #postMI travel to #brain and cause #neuroinflammation, underlying #depression. Work of Ke Liao, PhD ahajournals.org/doi/epub/10.11…
Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, and mitochondrial function remain unaffected, suggesting that NAD depletion does not drive age-related muscle decline.
dlvr.it
Wonderful Research In Progress update by NIH T32 Fellow, Jonah Zarrow, on developing novel #ncRNA drugs for #Duchenne muscular dystrophy. Important work for #DMD! @eduardomarban.bsky.social @smidtheart.bsky.social @mda.org
Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy onlinelibrary.wiley.com/doi/full/10....
Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy
Background Oestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanism...
onlinelibrary.wiley.com
ICYMI - New #Review on #DNARepair In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways. 🔗 go.nature.com/4iSKphQ
Mechanisms and regulation of DNA end resection in the maintenance of genome stability - Nature Reviews Molecular Cell Biology
DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-transla...
go.nature.com
Recent paper published in @jclinical-invest.bsky.social from @eduardomarban.bsky.social & Ke Liao finds a #ncRNA that enhances #Treg cells that could potentially repair heart muscle damage after a #HeartAttack & be applied to a variety of inflammatory disorders. www.cedars-sinai.org/newsroom/pre...
Preclinical Study: After Heart Attack, a Boost in Anti-Inflammatory Cells Promoted Healing
A scientific technique that rapidly increases the body’s production of anti-inflammatory cells promoted healing from heart attacks in mice, according to a new study by investigators from the Smidt Hea...
cedars-sinai.org
New #SkeletalMuscle paper: Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers. #Myoblue tinyurl.com/4brsea2d
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers - Skeletal Musc...
Background Exercising with low muscle glycogen content can improve training adaptation, but the mechanisms underlying the muscular adaptation are still largely unknown. In this study, we measured subs...
tinyurl.com
Check out the in-press preview of our @jclinicalinvest paper on regulatory #Tcells — we discovered a #ncRNA that can enhance #Treg dynamics fast enough to improve #MI healing in vivo. New hope for refractory inflammatory and immune conditions? 🔗 www.jci.org/articles/vie...
@russellrogers.bsky.social discussed experiments w/Lefer Lab taking advantage of the mechanistic differences between #GLP1RA & #ncRNA #TY1 as therapeutics for #HFpEF. Compelling evidence for synergistic benefits in two rodent models! Potential for less skeletal muscle loss? @smidtheart.bsky.social
Pleased to share out latest work on cell therapy for #Duchenne. We show #deramiocel therapy initiated early protects against disease-related decline in muscle function. @eduardomarban.bsky.social @smidtheart.bsky.social @stemcellreports.bsky.social @mda.org
Long-term preservation of muscle function and structure by repeated administration of cardiosphere-derived cells in mdx mice
Duchenne muscular dystrophy (DMD) is a progressive disease associated with functional decline. Chronic administration of cardiosphere-derived cell therapy prevents disease-related functional decline f...
cell.com
Great opening lecture by #HFpEF pioneer @dakheartguy.bsky.social on #sarcomere abnormalities— huge differences in #calcium activated force in #myocytes from obese vs morbidly obese patients. Clinical correlation less evident… @smidtheart.bsky.social #CardioSky
Had a great time at the 75th anniversary meeting of the Muscular Dystrophy Association discussing our work on #ncRNA in #Duchenne MD. Honored to be a recognized as a grant recipient of MDA to study cell-free therapies for #DMD. @mda.org @eduardomarban.bsky.social @smidtheart.bsky.social
New Online! Nuclear and genome dynamics underlying DNA double-strand break repair
Nuclear and genome dynamics underlying DNA double-strand break repair
Nature Reviews Molecular Cell Biology, Published online: 17 March 2025; doi:10.1038/s41580-025-00828-1Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the…
bit.ly
Genetic tools for investigating the life cycle of extracellular vesicles
Genetic tools for investigating the life cycle of extracellular vesicles
Nature Reviews Bioengineering, Published online: 17 March 2025; doi:10.1038/s44222-025-00286-6A thorough understanding of the life cycle of extracellular vesicles is essential to unleash their full potential in biomarker identification and therapeutics…
nature.com
Studying metabolism? Pay attention to time of day Nice collaborative review led by Satchin Panda www.nature.com/articles/s42...
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
nature.com
New @NatureComms paper: MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers. #Myoblue tinyurl.com/xmdsv5ez
MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers - Nature Communications
The nuclear periphery is linked with transcriptional repression, but MyoD1 remains active during myoblast proliferation despite being in this compartment. Here, the authors show that WFS1 tethers MyoD...
tinyurl.com
New @ScienceAdvances paper: Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy. #DMD #Myoblue tinyurl.com/3jbcw9fp
Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy
Genome-wide survey of human and mouse DMD tissues suggests EZH2’s role in satellite cells; its inhibition improves prognosis.
tinyurl.com
Lactic acidosis: implications for human exercise performance link.springer.com/article/10.1...
Lactic acidosis: implications for human exercise performance - European Journal of Applied Physiology
During high-intensity exercise a lactic-acidosis occurs with raised myoplasmic and plasma concentrations of lactate− and protons ([lactate−], [H+] or pH). We critically evaluate whether this causes/co...
link.springer.com
A short story: “A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity” @faseborg.bsky.social #myoblue
A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity
Muscle stem cells (satellite cells) promote adult skeletal muscle adaptation. The presence of satellite cells affects the skeletal muscle methylome response to lifelong wheel running - specifically i...
faseb.onlinelibrary.wiley.com
In 2024, Cedars Sinai performed 682 solid organ transplants, including 137 #HeartTransplants. It is the remarkable generosity of organ donors & their families that allowed our transplant teams to give 682 patients the chance to have longer and healthier lives. 🔗 cedars-sinai.org/newsroom/ced...
Inspiring kickoff to @fda.gov Cell Therapy workshop with keynote lecture by Sally Temple— PSC-derived neural cells are coming into their own! FDA CBER has been highly supportive of this transformative field.
In an effort to pretend life is normal and we can just talk science, our #journalclub today featured Liz on the lasting epigenomic traces of #obesity; Diana on ML-directed #protein #evolution; and James critiqued #iPSC #cardiomyocyte sheets. A welcome distraction from the prevailing woes about NIH.
On Feb 25, @fda.gov is proceeding with its scheduled workshop on #celltherapy. The agenda starts with an address by CBER Director Peter Marks, WarpSpeed hero, and is packed thereafter. Tune in for my session at 230PM EST. 🔗 www.fda.gov/news-events/...
Cell Therapies and Tissue-Based Products: A Public Workshop on Generat
CBER, OTP is hosting a virtual scientific public workshop on February 25, 2025, titled “Cell Therapies and Tissue-based Products: A Public Workshop on Generating Scientific Evidence to Facilitate Deve...
fda.gov
Stimulating #labmeeting today by #postdoc Salwa Soussi, PhD on #aging and how it is modulated by novel #RNAdrug #TY1. Strong evidence for central role of #cGAS #STING in cardiac #senescence. Animated discussion followed!
Identifying specific functional roles for senescence across cell types www.cell.com/cell/fulltex...
Identifying specific functional roles for senescence across cell types
A dual recombinase-mediated genetic system for cell-type-specific lineage tracing, ablation, and gene manipulation of senescent cells reveals distinct roles of senescence across cell types.
cell.com
Native DGC structure rationalizes muscular dystrophy-causing mutations www.nature.com/articles/s41...
Native DGC structure rationalizes muscular dystrophy-causing mutations - Nature
The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy.
nature.com
Proud to have our own @drmarthagulati.bsky.social of @smidtheart.bsky.social speaking at the first-ever White House Conference on Women’s Health Research, hosted by President Biden and the First Lady.👍👏
