Visualization and Quantitative Analysis of Genotoxin-induced PARP1/PARP2 Activation in Cells using a Fluorescent Fusion Protein-based Reporter - PubMed

Poly(ADP-ribose) (PAR) is a polymer of ADP-ribose synthesized by four members of the ADP-ribose polymerase family of enzymes-PARP1, PARP2, PARP5a, and PARP5b. However, only PARP1 and PARP2 synthesize ...

pubmed.ncbi.nlm.nih.gov

US Congress set to reject Trump’s sweeping science budget cuts

Lawmakers announce legislation that would actually increase funding for basic research by more than 2%.

nature.com

Exploiting metabolic vulnerabilities to improve cancer therapeutics

Over the past decade, our understanding of cancer metabolism has advanced significantly, revealing a complex and dynamic landscape of metabolic reprogramming that facilitates tumor progression and pro...

cell.com

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis

Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p

academic.oup.com

Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis

Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p

academic.oup.com

Exploiting metabolic vulnerabilities to improve cancer therapeutics

Over the past decade, our understanding of cancer metabolism has advanced significantly, revealing a complex and dynamic landscape of metabolic reprogramming that facilitates tumor progression and pro...

cell.com

Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion

President Donald Trump is leading an Olympics task force to handle security issues that are already being handled for the 2028 Games in Los Angeles.

usatoday.com

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology

RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...

nature.com

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

nature.com

2025 Samuel H. Wilson Award for Studies on DNA Repair Winner - Environmental Mutagenesis and Genomics Society

Mark Hedglin, PhD Assistant Professor of Chemistry, The Pennsylvania State UniversityPenn State Huck Institute of the Life Sciences, Center for Structural Biology  Penn State Huck Institute of the Life Sciences, Molecular, Cellular, and Integrative Biosciences (MCIBS)

emgs-us.org

TRIP12’s role in the governance of DNA polymerase β involvement in DNA damage response and repair

Abstract. The multitude of DNA lesion types, and the nuclear dynamic context in which they occur, presents a challenge for genome integrity maintenance as

academic.oup.com

Judge rules some NIH grant cuts illegal, saying he's never seen such discrimination in 40 years

A federal judge says it was illegal for the Trump administration to cancel several hundred research grants issued by the National Institutes of Health.

apnews.com

NIH scientists publish declaration criticizing Trump's deep cuts in public health research

Scores of National Institutes of Health researchers and staffers have come forward to send their Trump-appointed leader a letter challenging policies they say undermine the NIH mission.

apnews.com

DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint

Head and Neck Squamous Cell Carcinoma (HNSCC) imposes a significant health burden, necessitating innovative therapeutic strategies to enhance treatmen…

sciencedirect.com

Science in War, Science in Peace: The Origins of the NSF - JSTOR Daily

The 1950 establishment of a federal agency devoted to space, physics, and more belied a cross-party consensus that such disciplines were vital to national interest.

daily.jstor.org

Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)

The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.

nytimes.com

Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage

Protein poly-ADP-ribosylation (PARylation) is a post-translational modification formed by transferring successive units of ADP-ribose to target protei…

sciencedirect.com

Renewal of NIH grants linked to more innovative results, study finds

Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.

go.nature.com

‘50501’ protesters denounce Trump administration in nationwide rallies while supporting to impacted communities | CNN

A national day of action against President Donald Trump and his administration has united an outpouring of protesters across the country who are rallying in defiance of what they describe as a relentl...

cnn.com

Opinion | A Playbook for Standing Up to President Trump

Law firms and universities do not need to capitulate. Here’s how they can fight back.

nytimes.com

Sam Wilson Award Application Form - Environmental Mutagenesis and Genomics Society

11/28/2023July 2023 EMM Editor's Choice Article

emgs-us.org