Sachin Gadani
@saching.bsky.social
Neurologist into neuroscience, immunology, sci-fi, retro games, and Indian classical music. Assistant professor at the University of Pittsburgh. https://www.gadani-lab.com/
The Gadani Lab at the University of Pittsburgh is recruiting a post-doc! We are a new neuroimmunology lab interested in progressive multiple sclerosis, meningeal inflammation, and reactive glia. We are looking for a PhD scientist to spearhead funded research on Treg–glia interactions.
Post Doctoral.Post Doctoral.Associate
Click the link provided to see the complete job description.
cfopitt.taleo.net
What accounts for the progression from healthy aging to Alzheimer's disease over an extended period of time? The critical role of the immune system, particularly T cells and microglia. A new, excellent review www.cell.com/immunity/abs...
The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃
mayo.edu
How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question: rdcu.be/e4nfP.
Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos
Nature Neuroscience - Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective...
rdcu.be
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch 🧪 www.science.org/doi/full/10....
science.org
www.nature.com/articles/s41... Peripheral infection wires T cells in the brain 🧪
Peripheral infection wires T cells in the brain - Nature Immunology
Research shows that previous peripheral microbial encounters can prime the entry of memory T cells into the brain, reshaping neuroimmune surveillance and altering seizure severity through microorganis...
nature.com
www.cell.com/cell/abstrac... STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging 🧪
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging
Single-cell transcriptomics analysis and multimodal profiling (STAMP) by imaging enables single-cell analysis of cells in suspension without the need for sequencing. The markedly reduced costs and fle...
cell.com
We are looking for a research technician to join our neuroimmunology group at the University of Pittsburgh. Please share to anyone who may be interested! Posting: cfopitt.taleo.net/careersectio...
Laboratory Research Technician IV
Click the link provided to see the complete job description.
cfopitt.taleo.net
www.nature.com/articles/s41... 🧪 A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting - Nature Neuroscience
The authors describe a mechanism for the clearance of macromolecules from cerebrospinal fluid in which macromolecules traverse from periarterial to perivenous spaces, at sites where intersecting lepto...
nature.com
Very pleased to co-write this review with Bruce Cree and Steve Hauser on the future of #multiplesclerosis treatment onlinelibrary.wiley.com/doi/10.1002/...
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, gui....
onlinelibrary.wiley.com
Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome jamanetwork.com/journals/jam...
Prognostic Factors for Multiple Sclerosis Symptoms in Radiologically Isolated Syndrome
This study attempts to identify prognostic factors at radiologically isolated syndrome diagnosis associated with the development of multiple sclerosis symptoms.
jamanetwork.com
Increased CSF drainage by non-invasive manipulation of cervical lymphatics 🧪 www.nature.com/articles/s41...
Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature
The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.
nature.com
"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger” an $18 Billion cut Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced www.statnews.com/2025/05/30/n...
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development 🧪 www.nature.com/articles/s41...
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development - Nature Neuroscience
The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates ...
nature.com
Nice progressive MS review by Volker Siffrin: Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation onlinelibrary.wiley.com/doi/10.1002/...
Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation
Multiple sclerosis (MS) is the most common non-infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmu....
onlinelibrary.wiley.com
Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉 authors.elsevier.com/a/1l7l75FFzL...
authors.elsevier.com
Insightful perspective from Dr. Calabresi @pcalabresi.bsky.social on recently published BTKi multiple sclerosis trials. Progress toward Mitigating Disability Progression in Multiple Sclerosis www.nejm.org/doi/full/10....
Progress toward Mitigating Disability Progression in Multiple Sclerosis | NEJM
Multiple sclerosis is the most common cause of progressive neurologic disability in young adults. There had been no treatments for the disease, except for glucocorticoids, which were used for more ...
nejm.org
Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...
Inflammasome signaling in astrocytes modulates hippocampal plasticity
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...
cell.com
Inflammasome signaling in astrocytes modulates hippocampal plasticity 🧪 www.cell.com/immunity/ful...
Inflammasome signaling in astrocytes modulates hippocampal plasticity
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...
cell.com
Redefining CNS immune privilege - Nature Reviews Immunology www.nature.com/articles/s41...
Redefining CNS immune privilege - Nature Reviews Immunology
In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...
nature.com
Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
dlvr.it
Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis 🧪 www.nature.com/articles/s41...
Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis - Nature Medicine
This study identifies a unique multiple sclerosis lesion, the broad rim lesion, which is associated with rapid disease progression and marked by a distinct inflammatory profile involving innate inflam...
nature.com
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity 🧪 www.science.org/doi/abs/10.1...
T–B cell cooperation in ectopic lymphoid follicles propagates CNS autoimmunity
T and B cells cooperate in meningeal eLFs to promote differentiation and clonal expansion of B cells and reactivation of CNS T cells.
science.org
Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity. 🧪 rupress.org/jem/article/...
Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity | Journal of Experimental Medicine | Rockefeller University Press
Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity. IL-33 ablation reduces persistence and TCF-1low effector T cell gen
rupress.org
‼️BIG news ‼️ #ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing! Hurry up to register while prices are low! See you in Boston in October! genelayinstitute.org/rtn/
ReThink - The Gene Lay Institute
genelayinstitute.org
In an attempt to reproduce stimulus-triggered acquisition of pluripotency (STAP) before those papers were retracted, this group stumbled upon a population of neural stem cells in the periphery. www.nature.com/articles/s41...
Multipotent neural stem cells originating from neuroepithelium exist outside the mouse central nervous system - Nature Cell Biology
Han et al. report the existence of neural stem cells (NSCs) outside the central nervous system and show that these peripheral NSCs display features similar to brain NSCs, including the ability to diff...
nature.com
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB www.cell.com/cell/fulltex...
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB
Mapping the expression of all five IL-17 receptor subunits in the mouse brain reveals how IL-17 cytokines shape social behaviors by modulating neuronal activity within the somatosensory cortex.
cell.com
Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration Nice review on microglia states--figure 1 would be helpful if you ever have to annotate microglia single cell data, and they include a nice tool to automate the process. www.nature.com/articles/s41...
Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration - Nature Neuroscience
Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.
nature.com
