Samuel A. Myers' lab
@samyers-lab.bsky.social
Laboratory for Immunochemical Circuits at the La Jolla Institute for Immunology. Dept. of Pharmacology and Moore's Cancer Center, UCSD. Global Autoimmune Institute Assistant Professor. samyerslab.org
Experimental LJI cancer strategy wins top honors from Nucleate San Diego! Team leader Erik Ehinger, Ph.D., shares how new #cancer strategy could counteract T cell "exhaustion:" www.lji.org/news-events/... #immunology #ImmuneSystem #CancerResearch #SanDiego #LaJolla
Experimental LJI cancer strategy wins top honors from Nucleate San Diego
Team leader Erik Ehinger, Ph.D., is on a mission to help more patients benefit from cancer immunotherapies.
lji.org
Don't miss Thursday's seminar by Dr. Greg Ducker @duckerlab.bsky.social entitled "Follow the Carbon: From Molecules to Mechanisms of Disease." Thurs Sept 3, 12pm in HSEB 1750!
A Zika virus vaccine with E protein fusion loop mutations protects via CD8+ T cells @natmicrobiol.nature.com www.nature.com/articles/s41... @lji.org
The window for public comments is still open but closes soon (tonight!) for NSF's proposed changes to require approval by political appointees, add restrictions to publishing & communication of research, and ban international collaborations.
Stand Up for Science!@standupforscience.net · last wk.🚨WARNING🚨 Today is the LAST DAY to leave your public comment on the NSF Proposal. The Proposal implements some of Vought's Science-Destroying OMB Proposal plans in advance: zurl.co/9nywR Leave your public comment TODAY using our guide & tool: fight2win.standupforscience.net/campaign/Pro...
Farewell Feli,best of luck on your last year in undergrad. Great to have you around this Summer. May your future be as bright as it was taking this photo. He's doing a maxi prep then driving home tonight. #dedicated.
The best part about being a PI is that I dont have to submit the manuscripts through the journal's portal anymore. I get to let the students and postdocs "experience" it. >:)
🗓️ Sept. 15, from 1:30-3:00 PM, @ Scripps Seaside Forum Join #SanDiego scientists for the LEAD Day scientific panel on "AI and Multi-Omics: Building a New Era of Autoimmune and Chronic Disease Research." #AI #Health #Medicine Free registration + complementary shuttle 👉 Sign up today: bit.ly/4g5hx7l
My lab at Stanford University School of Medicine is recruiting! We are looking for a postdoc at the interface of quantitative proteomics, structural biology and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/...
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
postdocs.stanford.edu
Our study published today @science.org shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome: doi.org/10.1126/scie... With outstanding Perspective from @aurelien-doucet.bsky.social & @retrogenomics.bsky.social: doi.org/10.1126/scie...
You can definitely tell @sandiegocomic-con.bsky.social is here. Welcome! And I'll see you Sunday.
Hi #TEsky, please remember that we have an amazing community in the TransposonsWorldWide slack channel (join.slack.com/t/transposon...), which I encourage you to join. Another great resource is tehub.org. Please share !
Join TransposonsWorldwide on Slack
Slack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.
join.slack.com
1/ Excited to share a new preprint! My PhD student Claire asked why neonatal mice become resistant to experimental cholera as they age. Turns out, early-life acquisition of maternally transmitted lactobacilli helps protect against experimental cholera www.biorxiv.org/content/10.6...
Early-life acquisition of Lactobacillaceae protects against experimental cholera
Cholera causes severe diarrheal illness in young children, but the mechanisms underlying age-dependent susceptibility remain unclear. Experimental cholera in neonatal mice recapitulates age-dependent ...
biorxiv.org
Oh yeah, dissect that overlapping transcriptional functionnnn
bioRxivpreprint@biorxivpreprint.bsky.social · 2mo agoSmad1 and Smad5 differentially transduce BMP signaling during in vitro differentiation of mouse embryonic stem cells into dorsal interneurons https://www.biorxiv.org/content/10.64898/2026.06.30.735733v1
Ryan Rising creates programmes that help people who have been incarcerated to access academic opportunities go.nature.com/3RmOzWU
I want to see a prison-to-PhD pipeline
Ryan Rising creates programmes that help people who have been incarcerated to access academic opportunities.
go.nature.com
Check out our recent Spotlight article in @cp-trendsendomet.bsky.social discussing intriguing new findings in mitochondrial lactate metabolism, written by graduate student Serwah Danquah! Paywall bypass link: authors.elsevier.com/a/1nNcv3jDgW...
Trends in Endocrinology and Metabolism@cp-trendsendomet.bsky.social · 2mo agoOnline Now: Mitochondria produce lactate to vent redox pressure #trends #endocrinology #metabolism
(BioRxiv All) GLproxScape reconstructs spatial chromatin occupancy landscapes from tiled genomic locus proteomics: Genomic locus proteomics combines proximity labeling with mass spectrometry to identify the proteins associated with user-defined genomic loci. However,… #BioRxiv #MassSpecRSS
GLproxScape reconstructs spatial chromatin occupancy landscapes from tiled genomic locus proteomics
Genomic locus proteomics combines proximity labeling with mass spectrometry to identify the proteins associated with user-defined genomic loci. However, per-region enrichment values from tiledguide designs are typically pooled before hit calling, collapsing the latent spatial structure encodedby overlapping measurements. Here, we describe GLproxScape, an R package that treats per-region enrichments as indirect spatial measurements and reconstructs latent chromatin occupancylandscapes through a Gaussian labeling-kernel forward model. Sequence-specific transcriptionfactors are resolved by motif-anchored non-negative least-squares deconvolution against JASPARor HOCOMOCO position weight matrices, while chromatin regulators which lack defined DNA-binding motifs are inferred as broad occupancy zones, enabling recovery of overlapping membersof multi-subunit complexes. Applied to published genomic locus proteomics datasets at the humanTERT, MYC, FOXP2, and FOXQ1 loci and the mouse Ripk3 locus, GLproxScape recovered knownregulators with predicted positions independently supported by ChIP-Atlas peaks, reconstructedcandidate co-binding relationships, and identified chromatin complexes inaccessible to pooledanalyses. Systematic sgRNA-ablation experiments further showed that densely tiled designsimprove event recovery and positional stability, providing concrete experimental guidance for futuregenomic locus proteomics studies.
dlvr.it
Preprint out! We optimized synchro-PASEF for phosphoproteomics & found equivalent biological insights to dia-PASEF despite fewer total IDs. Practical tip: apply retention time summation factor 2 to any PASEF phosphoproteomics data—you'll gain IDs and precision. www.biorxiv.org/content/10.6...
Systematic optimization and benchmarking of synchro-PASEF for high-throughput phosphoproteome profiling
High-throughput data-independent acquisition (DIA) workflows paired with short chromatographic separations are increasingly adopted for systems biology and clinical proteomics. However, narrower peak ...
biorxiv.org
I think my lab does this to me but I can't ever remember.
Tits McGee@scientits.bsky.social · 2mo ago‘Say yes and never do it’ Mel Brooks knew how to deal with the studios
Stacy Malaker @yalepress.bsky.social representing #glycotime and #massspec @onoinitiative.bsky.social chem bio symposium @stanford-chemh.bsky.social
How does aging reshape a tissue that must continually rebuild itself hundreds of times? Our latest: Using spatial transcriptomics, we find that ovarian aging disrupts the coordination of cells across space and time before reproductive cycles stop. #OvarianAging
Nature Aging@nataging.nature.com · 2mo agoOnline now! Spatial atlas of aging mouse ovary shows that reproductive decline reflects progressive loss of spatiotemporal coordination #OvarianAging #WomensHealth @hattaca.bsky.social @davidsebfischer.bsky.social @akochersberger.bsky.social @jennifergarrison.bsky.social doi.org/10.1038/s435...
Now published in Cell Reports! @cellpress.bsky.social www.cell.com/cell-reports... My postdoc Dr. Maria de la Paz Gutierrez led this work showing that cholera toxin drives epithelial L-lactate production in the small intestine, creating a nutrient that Vibrio cholerae exploits during disease
Cholera-toxin-induced disease generates epithelial-cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine
Gutierrez et al. show that cholera toxin induces epithelial LDHA-dependent L-lactate production in the small intestine, creating a nutrient niche that Vibrio cholerae exploits through LldD-mediated L-...
cell.com
Fabian Rivera-Chávez@fabianrchavez.bsky.social · last yr.1/ Excited to share the first preprint from my lab! 🎉 My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut. Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
Come discuss advances in research and patient care regarding O-GlcNAc transferase, OGT, and it's mutations that lead it neurodevelopmental disorders mbg.au.dk/ogtid #glycotime
Come discuss advances in research and patient care regarding O-GlcNAc transferase, OGT, and it's mutations that lead it neurodevelopmental disorders mbg.au.dk/ogtid #glycotime
Excited to introduce MIRA-MS, a real time artificial intelligence prediction tool for analysis of MHC peptides! If you are at ASMS, check out poster 459 on Thursday. www.biorxiv.org/content/10.6...
biorxiv.org