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Gael Cristofari

@retrogenomics.bsky.social

Group leader at the Institute for Research on Cancer and Aging of Nice (IRCAN) CNRS, Inserm, University Cote d'Azur, Nice, France https://ircan.org/en/research/gael-cristofari Repetitive DNA, Reverse transcriptases, Retrotransposons, Genomics #transposon

21 Posts640 Follower306 Folgt
Clément Goubert@clementgoubert.bsky.social · last mo.

Major development in the #Transposon world! Repbase is joining the Dfam project and becomes open-access! link.springer.com/article/10.1...

Unifying Repbase and Dfam: a new open foundation for transposable element research - Mobile DNA

Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curati...

link.springer.com

Dfam Database of Transposable Elements@dfam.bsky.social · last mo.

A New Open Foundation for TE Research: GIRI is transitioning the full Repbase collection to an open-access license and joining the Dfam effort to help build a unified open resource for transposable element research. Full announcement: tinyurl.com/48665xss

Mathieu Lupien@matlupien.bsky.social · 3mo ago

Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness. We found that transposable elements sustain stem-like states in AML and predict patient outcomes. www.nature.com/articles/s41...

Alterations of chromatin state at transposable elements rewire stemness in acute myeloid leukemia - Nature Genetics

By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...

nature.com

Hervé (rv) Técher@rvtecher.bsky.social · 5mo ago

Happy to share the first research article of our team. We report that foreign DNA, such as ISD, activates DNA damage signaling mainly through DNA-PK. @ircan.bsky.social @univcotedazur.bsky.social @cnrsbiologie.bsky.social @canceropolesud.bsky.social www.jbc.org/article/S002...

Interferon Stimulatory DNA activates the DNA damage signaling through ATM and DNA-PK sensing

In eukaryotic cells, DNA is normally confined in the nucleus and mitochondria and the presence of DNA in the cytoplasm is a danger signal that activates innate immune responses. Upon detection of cyto...

jbc.org

Joanna W Jachowicz@jjachowicz.bsky.social · 5mo ago

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️ We are looking for a postdoc to join our team at @imbavienna.bsky.social More details 👇🏻

Institute of Molecular Biotechnology@imbavienna.bsky.social · 5mo ago

We are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below 👇

ASAP Team Jakobsson@jakobssonasap.bsky.social · 5mo ago

Are you interested in achieving efficient silencing of transposable elements using CRISPRi? 🧬 🧫 Go ahead and have a look at this STAR protocols where Adami et al. share all the tips & tricks they use in the Jakobsson lab. @anitaada.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social

Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells

Here, we present a workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). We describe steps for designing guide RNAs (gRNAs) to target ...

cell.com

Jose Tubio’s lab - Mobile Genomes@mobilegenomes.bsky.social · 5mo ago

Today in @science.org: We are pleased to present our last work entitled: "Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis" by Zumalave et al. www.science.org/doi/10.1126/...

Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis

LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

science.org

Johann Confais@johannconfais.bsky.social · 6mo ago

🚨📢📄 Article in press in Genome Biology doi.org/10.1186/s130... We introduce panREPET, a reference-free pipeline to detect shared transposable element (TE) insertions across pangenomes and retrace their evolutionary dynamics #TEsky 🧵👇

A reference-free pipeline for detecting shared transposable elements from pan-genomes to retrace their dynamics in a species - Genome Biology

Background The role of transposable elements (TEs) in host adaptation has gained interest in recent years. Individuals of the same species undergo independent TE insertions, providing genetic variabil...

doi.org

Julius Brennecke@juliusbrennecke.bsky.social · last yr.

Pls. share widely Calling all transposon fans & lovers of genetic innovation MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025 → Vibrant & friendly community → Cutting-edge talks from mechanisms to physiology → Plenty of surprises (TEs never stop innovating) submit abstract by July 29

EMBL Events@events.embl.org · last yr.

⏰ Abstract deadline for 'The mobile genome' is 29 July! 👉 https://s.embl.org/mge25-01-bl Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍 ⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out! #EMBOMobileGenome

Juliane Glaser@julianeg.bsky.social · last yr.

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics

Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

nature.com

EMBL Events@events.embl.org · 2y ago

📣 #EMBOMobileGenome is open for registrations! Assembling experts in genomics, epigenetics, structural biology, evolutionary biology, and developmental biology to discuss the broad impact of TEs on organismal biology. 🧬🔍 📜 Submit abstract by 29 July! 👉🏼 https://s.embl.org/mge25-01-bl

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Rita Rebollo@ritarebollo.bsky.social · 3y ago

Forgot to say we already have at least 230 registered! A record! And if we are more than 200 at the gala diner, we can have our own dance floor 🕺 #TEworldwide

Rita Rebollo@ritarebollo.bsky.social · 3y ago

Hi! Only two more weeks to register for #ICTE2024 & to submit an abstract for a talk on one of the different topics below: 1) TEs, genome evolution and adaptation 2) TEs in health and disease 3) TE control & epigenetics 4) Transposition mechanisms and applications See you soon! #TEsky

Gael Cristofari@retrogenomics.bsky.social · 3y ago

Did you ever wondered how "jumping genes" actually jump? 2 papers now published in Nature show the 3D structure of the enzyme responsible for this process for human LINE-1 retrotransposon (links 👇). Congrats to the authors! #TEsky #TEworldwide #transposon 🧪🧬🔬"Genome Stability" 👇