🧵 New preprint from our group, in collaboration with the @marcbuhler.bsky.social lab at FMI Basel and the Thalassinos lab at UCL. A long project and a finding we're really pleased with. Thread 👇 www.biorxiv.org/content/10.6...

Congratulations to the Chloe Hall and the Chaplin group! We're very proud to be part of this fantastic effort to produce structures of NHEJ assemblies on nucleosomes. This brings us closer to understanding how DNA repair machinery deals with a chromatin substrate: www.nature.com/articles/s41...

Please RS/RT. #GordonConference "Histone and DNA Modifications" Program is now online 🍾 #epigenetics #chromatin #histones 20.-25. July. Il Ciocco 🇮🇹 Register now: ➡️ shorturl.at/AtAjz Exciting speaker lineup, many slots for talks selected from abstracts

🧬 1/ Heterochromatin protein 1 (HP1) still surprises us after all these years: It simply sticks to chromatin when pericentric heterochromatin domains – the chromocenters – are activated in mouse fibroblasts and acts as a local rather than global repressor. New preprint: doi.org/10.1101/2024...

I am recruiting a postdoc with experience in Protein Biochemistry, Structural Biology & Chromatin Biology. If you are passionate about the complex world of chromatin modifications, please contact me for more details 🙏. Location: SAiGENCI, Adelaide, Australia 🦘🍷🏄🏖️🇦🇺

📢 #PhD Position 🎓 @leicstructbio.bsky.social @mcbleicester.bsky.social. Developing protein-based therapies for mesothelioma. Work with experts in epigenetics & cancer biology. Apply by Jan 10, 2025. #PhDSky #AcademicSky Details: www.schalchlab.org/mesoinject

We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression. Deadline: 16th January 2025. www.findaphd.com/phds/project...

Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester on FindAPhD.com

PhD Project - Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester, listed on FindAPhD.com

findaphd.com

🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky #AcademicSky Details: tinyurl.com/4fhavzxh

Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester on FindAPhD.com

PhD Project - Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester, listed on FindAPhD.com

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Gutting when you find your dream project done and dusted on bioRxiv. Du et al. performed an impressive tour-de-force to solve the Clr4-H3K14ub structure. Great to see that the ubiquitin-binding region we found by XDS-MS matches the crystal structure perfectly! www.biorxiv.org/content/10.1...

Mechanistic Insights into the Stimulation of the Histone H3K9 Methyltransferase Clr4 by Proximal H3K14 Ubiquitination

H3K9 methylation is an evolutionarily conserved hallmark of heterochromatin and plays crucial roles in chromosome segregation, genome stability, and gene expression regulation. Clr4 is the sole histon...

biorxiv.org

Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg

In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography https://www.biorxiv.org/content/10.1101/2024.02.21.581285v1

In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography https://www.biorxiv.org/content/10.1101/2024.02.21.581285v1

Long terminal repeat (LTR) retrotransposons belong to the transposable elements (TE), autonomously r

biorxiv.org