Next summer's Epigenetics GRC (I'm co-chairing with Deborah Bouch'is) is shaping up nicely with an all-star lineup of speakers working on a broad range of organisms and systems and everything from molecular mechanisms to new phenomena. Apply and put it on your calendar! www.grc.org/epigenetics-...

Preprint alert! 🚨 We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by truncating variants in ASXL1. This project was led by PhD student Emma Doyle, one of the OG Conway lab members 💪. 1/6 www.biorxiv.org/content/10.6...

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

The PR-DUB complex is responsible for erasing the repressive histone modification, H2AK119ub1. ASXL1-3 proteins are mutually exclusive catalytic partners of BAP1 in the PR-DUB complex. Somatic heteroz...

biorxiv.org

I am very excited to share the work of my PhD with @eddaschulz.bsky.social, now on BioRxiv! 🎉 🧵⬇️ (1/9) How does the transcription↔️chromatin crosstalk ensure monoallelic expression?

bioRxivpreprint@biorxivpreprint.bsky.social · last wk.

Transcription-dependent heterochromatin at the Xist promoter shapes the random choice of the inactive X chromosome https://www.biorxiv.org/content/10.64898/2026.07.22.737064v1

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Analog intrinsic recoding measures RNA dynamics without chemical conversion

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

biorxiv.org

Congrats to the Beamish #UMichMed and Watts #NIEHS labs on the new paper investigating the requirement for Sox8 in transcription, histone modification, and cell identity/function in proximal tubule cells!: www.sciencedirect.com/science/arti...

PAX8 controls proximal tubule epithelial identity and stress response through epigenetic modification of distal regulatory elements

The kidney proximal tubule undergoes dramatic cell-state transformations during recovery from injury, serving as a unique model to study the dynamic t…

sciencedirect.com

40 individuals with the clinical picture of FOXG1 syndrome and a completely intact FOXG1 gene. So what’s going wrong then? Our new paper in @natcomms.nature.com traces the answer to a stretch of non-coding DNA 665 kb away from the gene. (1/7)

Congrats to @charlyguardia.bsky.social and @asmitasingh.bsky.social on the new paper! Awesome work out of RDBL here at NIEHS!

Carlos Guardia@charlyguardia.bsky.social · 2w ago

(1/9) 🚨 Our lab’s first major paper is now out in Nature Communications! We show that ATG9A and ATG2A/B act as lipid-dependent gatekeepers linking autophagosome/amphisome formation to small extracellular vesicle (sEV) secretion.

Learn to say no early on. It is not your problem that there are not enough women around to fill quotas.

Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:

Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics

Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...

doi.org

Luca Giorgetti lab @FMI@lucagiorgetti.bsky.social · last yr.

Celebrating 10 years of our lab with a new preprint: www.biorxiv.org/content/10.1... How does enhancer location within a TAD control transcriptional bursts from a cognate promoter? Experiments by Jana Tünnermann and modelling by Gregory Roth

Excited to share the first preprint from my lab! Transcription has been implicated in regulating SMC complex function, but how this works has been unclear. Here, we use a yeast quiescence model to examine how transcription targets condensin.

bioRxivpreprint@biorxivpreprint.bsky.social · 3w ago

Asymmetric condensin loop extrusion is regulated by RPA-coated single-stranded DNA in quiescent cells https://www.biorxiv.org/content/10.64898/2026.07.10.737861v1

📢 Attention Recent Graduates 📢 I’m hiring a Postgraduate Research Associate to join my growing team at Yale! If you’re passionate about RNA biology/Gene Regulation and are looking to gain hand-on research experience before graduate school, please consider applying! postdocs.yale.edu/posts/2026-0...

Still very impressed by the work of the @andersshansen.bsky.social team. Excited to see how these findings extend to endogenous enhancers in future studies!

jp flores (he/him)@jpflores.rbind.io · 4w ago

I’ve just published a #PreprintReview of “Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation” on @prereview.bsky.social prereview.org/reviews/2124...

This is brilliant! www.nature.com/articles/s41...

Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing - Nature Genetics

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

nature.com

The Kaplan Lab at the University of Pittsburgh has received funds to recruit a postdoctoral fellow to establish a multiplexed assay of variant effect for a disease gene. This relates to our studies on RNA Polymerase II. This project requires experience with human cell lines and genomics 1/

Apply to be part of our fall seminar series!

FragileNucleosome@fnucleosome.bsky.social · 2mo ago

We just started our summer break, but we're also planning our September-December seminar schedule! If you have an exciting chromatin/transcription story that will be ready for the spotlight by then, use the survey below to nominate yourself to give a #FNucleosome talk 🧬🧬 forms.gle/1EKYN2Nt79ar...

FASTEN YOUR SEATBELTS: Tamina Weiss, inspired by previous data from @ppagella86.bsky.social found that beta-catenin is more than an adaptor protein downstream of #WNT It is an orchestrator that scouts and opens enhancers for transcriptional activation @biorxivpreprint.bsky.social

bioRxivpreprint@biorxivpreprint.bsky.social · 2mo ago

Enhancer pioneering activity of Wnt/β-catenin signaling https://www.biorxiv.org/content/10.64898/2026.06.12.731851v1

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Very excited to present some of my PhD work from the @claudiocantu81.bsky.social Cantù lab tomorrow!

FragileNucleosome@fnucleosome.bsky.social · 2mo ago

🧬This Wednesday will be the final seminar of the Spring 2026 #FNucleosome schedule, and we've got a great one lined up! Join us to hear about the outstanding research of @annanordin.bsky.social, @valentinabaderna.bsky.social, and @kezlane.bsky.social! register here: us06web.zoom.us/webinar/regi...

Join us on Wednesday for some great science before the world cup matches!!

FragileNucleosome@fnucleosome.bsky.social · 2mo ago

🧬This Wednesday will be the final seminar of the Spring 2026 #FNucleosome schedule, and we've got a great one lined up! Join us to hear about the outstanding research of @annanordin.bsky.social, @valentinabaderna.bsky.social, and @kezlane.bsky.social! register here: us06web.zoom.us/webinar/regi...

Excited to share the first pre-print from our lab!! Check it out here! www.biorxiv.org/content/10.6... We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

We’ve recently been awarded a MIRA R35 and an R01 to study non-canonical roles and missense mutations of the Polycomb system in health, cancer, and neurodevelopmental disorders. We are seeking an animal tech with lab manager duties. Please share!

See our handy graphical abstract and article for free here: bit.ly/4vsl845

Jon Henninger@jhenninger.bsky.social · 2mo ago

Check out our new work in Cell Systems @cp-cellsystems.bsky.social! Much of the biochemistry in the cell is organized by biomolecular condensates, but what mechanisms control the distribution of a given condensate throughout the cell? And is this mesoscale organization important for function?

🎉Save the date! Black In Neuro Week 2026 is July 27–Aug 2. We're celebrating our 6th annual BIN Week with returning favorites like #NeuroRacism, #NeuroAcrossTheDiaspora, and #BINRollCall plus a brand new theme: #BlackInTime. ✨ 🧠 #BINW26 #AReimaginedFuture

I am very grateful and excited about this opportunity! Big thank you to our fantastic team who have made this possible and to many supportive mentors 🙏

Max Planck Institute of Immunobiology and Epigenetics@mpi-ie.bsky.social · 2mo ago

We are over the moon! 🎈 Dr. Marieke Oudelaar joins the MPI-IE as a new #MaxPlanck Director, heading the newly established Department of Genome Biology She studies how the 3D folding of DNA controls gene expression – more details below ⬇️ Welcome to #Freiburg, @mariekeoudelaar.bsky.social!

Reminder that the Local Organic Intelligence Model located in your skull runs quite inexpensively on snacks and caffeine arstechnica.com/ai/2026/06/a...

AI costs how much? GitHub Copilot users react to new usage-based pricing system.

Some report burning through their whole monthly "AI credit" allotment in a single day.

arstechnica.com

We're starting in 45 minutes, register and join us to hear about the outstanding work Mark, Jake, and Sid are doing!

FragileNucleosome@fnucleosome.bsky.social · 2mo ago

🧬🧬🧬 Join us this Wednesday, June 3rd for exciting talks from three early career chromatin/transcription researchers: Mark Geisler, @jcornwallscoones.bsky.social, and @sidujain.bsky.social! register here: us06web.zoom.us/webinar/regi...

My Fragile Nucleosome seminar is now on YouTube www.youtube.com/watch?v=ksXp... I discuss our recent work showing that linker histone H1 behaves as a liquid-like glue for chromatin organization in living human cells 🧬 Paper: www.science.org/doi/full/10.... Huge thanks to @fnucleosome.bsky.social!

Kazuhiro Maeshima

YouTube video by Fragile Nucleosome

youtube.com

Don’t miss Jake’s talk this Wednesday! @jcornwallscoones.bsky.social

FragileNucleosome@fnucleosome.bsky.social · 2mo ago

🧬🧬🧬 Join us this Wednesday, June 3rd for exciting talks from three early career chromatin/transcription researchers: Mark Geisler, @jcornwallscoones.bsky.social, and @sidujain.bsky.social! register here: us06web.zoom.us/webinar/regi...