Yes, great descriptive visualization by @mullinslab.bsky.social. Will never look at sesame seeds and cats the same again. Looking forward to catching the next wave with @cathygalbraith.bsky.social, @sciencethecat.bsky.social, and @ulrikeboehm.bsky.social

What would it feel like to go with the flow inside a cell? A lovely new Current Biology Dispatch by Dyche Mullins on work led by Cathy & Jim Galbraith "expands our cellular imagination" to the cell's sluices, pumps, dams. doi.org/10.1016/j.cu... doi.org/10.1038/s414...

Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

It's an exciting day for #Fiji users! Now read and write @zarr.dev v3 and #OMEZarr v0.5. Don't want a million tiny files in your #zarr? Shard that sucker! Read the details here forum.image.sc/t/fiji-can-r...

Fiji can read and write Zarr3 & OME-Zarr v0.5 (new N5 release!)

Updating your Fiji-Latest installation will give you the newest versions of the N5 library, enabling OME-Zarr v0.5 / Zarr v3 support with sharding! What's new? Reading zarr 3 datasets (sharded and u...

forum.image.sc

@focalplane.bsky.social asked us for the behind the paper story on uncovering Compartmentalized Cytoplasmic Tradewinds. Read about it here. (along with a new YouTube video) A great collaboration with @sciencethecat.bsky.social and @ulrikeboehm.bsky.social focalplane.biologists.com/2026/07/09/c...

Cytoplasmic Tradewinds: How Cells Steer Proteins

Six imaging methods reveal cytoplasmic tradewinds: a hidden fluid flow that pushes soluble proteins using a leaky actin-myosin barrier.

focalplane.biologists.com

⚽🇩🇪 We are famous @heloisarts.bsky.social, we are mentioned in the Post as "other German fans" wapo.st/4aEAdrw I'm the one with the face paint 🤣

European soccer fans enjoy a brief fling with America’s air-conditioned culture

Despite a deadly heat wave at home, many say they won’t permanently embrace Americans’ electricity-guzzling amenity.

wapo.st

These stunning single-celled organisms can shape-shift & regenerate. Their trumpet-like shape inspired their name: stentor, after the herald in Greek mythology known for his booming voice. 📸: Confocal microscopy by Igor Siwanowicz, HHMI’s Janelia Research Campus

The amazing Geoff Daniels stopped by Janelia for a visit. Always great when old friends stop by. Good to see you both, Geoff and John! @abberior.rocks @hhmijanelia.bsky.social

(3/n) We engineering a synthetic 339 kb E-P pair in 'vacant' region - Vary E-P dist - +/- CTCF at E and P - See nice dot in RCMC maps - Can track E-P 3D distance and nascent RNA from 2Hz to 6+ hours using Super-Res Live Cell Imaging - Txn strictly dependent on E. - New DNA fluor label: synBsr1 (!)

I’m thrilled to announce that I am the voice behind a new @zeissgroup.bsky.social campaign focused on photonics—discover more about this exciting field and ZEISS’s pioneering role in it! 😀👉 www.zeiss.com/corporate/en/c/stories/insights/photonics.html

Technological innovation: Photonics & AI | ZEISS

Discover how ZEISS is advancing artificial intelligence through technological innovations and photonics, enabling advanced microchips and practical AI applications in science, medicine, and industry.

zeiss.com

Messi xkcd.com/3260/

😎 to have this out! --> stay tuned, this is a series about 📊#dataviz for #science 🧪

Nature Methods@natmethods.nature.com · 2mo ago

We are very excited to bring back our popular Points of View column, written by @helenajambor.bsky.social! Check out her first column in our July issue about the usage of color scales in scientific figures. www.nature.com/articles/s41...

All the countries I've lived in: 🇩🇪 (7:1 win) 🇸🇪 (5:1 win) 🇺🇸 (4:1 win) 🍀⚽🍀⚽🍀⚽ I'm clearly a lucky charm and I'm ready to accept immigration proposals.

I especially loved this historical Comment from Sunney Xie in the Focus issue, which describes how the stage was set for coherent Raman microscopy.

Nature Methods@natmethods.nature.com · last yr.

This issue features two historical Comments. The first is from Sunney Xie on the development of coherent Raman microscopy. www.nature.com/articles/s41...

Our June issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, an absolutely gorgeous image of neurites and mitochondria in a brain organoid, captured using the MOSAIC microscope. Paper here: www.nature.com/articles/s41...

#HHMIInvestigator Eric Betzig & team use a single microscope that does the work of a dozen, capturing life in 5D (3D + time + color). But the data it generates is too vast for humans to analyze alone, so they're building "a sherpa to guide us,” i.e. an AI to unlock MOSAIC's potential: bit.ly/3RN2GVj

The leadership and clarity of @MIT President Sally Kornbluth www.bostonglobe.com/2026/05/26/o...

America built the world’s greatest research engine. Now it’s shrinking. - The Boston Globe

At public and private universities across the country, high-impact science is being damaged and derailed.

bostonglobe.com

The MOSAIC paper is out in Nature Methods. For the record I went after this paper for *years* and was so happy when they sent it to me/us. www.nature.com/articles/s41...

A multimodal adaptive optical microscope for in vivo imaging from molecules to organisms - Nature Methods

MOSAIC is a versatile multimodal microscope that allows seamless transition between various light-sheet, two-photon, label-free and super-resolution modalities. It is demonstrated in various systems r...

nature.com

Thank you @fcspdc.bsky.social for hosting us today ♥️ #washingtondc @fcbayernmunich.bsky.social #fcbayern Love St. Pauli - Hate Racism!

There will never be another Vincent Kompany. Player management skills 100/10

Our May issue is live! 🎉 www.nature.com/nmeth/volume... On the cover, volumetric label-free imaging of a live model of the human blood–brain barrier with a self-localized ultrafast pencil beam. Paper here: www.nature.com/articles/s41...

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

Here’s our newly developed enhancer nucleosome biosensor imaged in primary human fibroblast. Staygold in the biosensor allowed us to image at very high temporal resolution to see some amazing dynamics

NASA just dropped 12,000 photos from the Artemis II mission. Too many to add to ArtemisTimeline.com, so I just put up a tool at ArtemisTimeline.com/vote so that people can vote on small batches allowing for all of the images to be sorted! (yes, I posted this before, but I had to fix something!)

Selfies with some of my legend-friends at the 10th Chesapeake Bay Area Single Molecule Biology Meeting! @jiexiaolab.bsky.social @successprocess.bsky.social #SingleMolecules #Janelia

It all started with (#2 in the series) New in Nature Methods - spontaneously blinking dyes for live cell super-resolution. No harsh chemicals or damaging light. 2 Nature family papers in two weeks 🤯 @rhodamine110.bsky.social @sciencethecat.bsky.social doi.org/10.1038/s415... doi.org/10.1038/s414...

Just out: A series of spontaneously blinking dyes for super-resolution microscopy with @rhodamine110.bsky.social and an incredible team of collaborators. www.nature.com/articles/s41... It's been an amazing few weeks -- this follows our cytoplasmic tradewinds paper. www.nature.com/articles/s41...

And this one took a while—736 days. I wrote about why there is more behind this paper than the chemistry. communities.springernature.com/posts/736-days

736 Days

communities.springernature.com

sOrganellomics is a new strategy to map cell state diversity and functional cell changes across healthy and diseased tissues! Check out the latest version now on BioRxiv - Congratulations @feliciano-lab.bsky.social !!