Great work for psychedelic research to overcome RCT-based epistemic authoritarianism, led by @sdmuthu.bsky.social and @tehseennoorani.bsky.social 👏👏👏. Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others. osf.io/preprints/ps... 🧪🧠💊

Yet another pointless (scientifically speaking) study of psychedelics. With no placebo response the design is clearly a mess. I guess you can juice your stock price but you’ll never see this get published … and if you don’t publish your participant information sheets then don’t bother ….

josh hardman@josh-hardman.bsky.social · 2y ago

Shares in GH Research ( $GHRS ) surged today as the company announced positive results from a Phase 2b study of its inhaled 5-MeO-DMT candidate for treatment-resistant depression. Here's a summary (image). And more: psychedelicalpha.com/news/gh-rese...

Please god. No more systematic reviews of psychedelics .... (at least for a while 😅)

This won’t be a popular view on the left but as a clinical trialist I am not sad to see the TPA go. The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….

Sarah Pallett@sarah4ilam.bsky.social · 2y ago

I’m particularly salty about the repeal of the Therapeutic Products Act going through all stages under urgency today. My relative who sells magic oxygenated water that cures cancer* and protects against COVID* because vaccines are evil^ is delighted, however. * it doesn’t x2 ^ they are not #nzpol

Always exciting to receive the investigational product for a new clinical trial. First time I’ve had one go through a ceremonial blessing process (karakia and waiata) though … (see below for details).

Suresh Muthukumaraswamy@sdmuthu.bsky.social · 2y ago

Seen Māori protests/haka on social media? Seen panels complaining of indigenous exclusion in psychedelic science? Check out our new pre-print: “Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms” osf.io/preprints/ps...

We’ve done this is humans. Paper in submission …

Scott Thompson, PhD@sthom003.bsky.social · 2y ago

Good morning #ACNP2024! Had enough neuroscience yet? Time to learn a little cardiology (as performed by neuroscientist. @Devineffinger.Bsky.social). Specifically, does chronic microdosing of LSD pose a cardiovascular risk by chronically activating 5HT2B receptors? Find out at poster W234 today!!

Interesting new study on "personality" change due to psilocybin administration. Lots in here, but just focusing on one element, they found that psilocybin in the lab reduced neuroticism, but not any other aspect of the Big 5. www.sciencedirect.com/science/arti... #psychedelicscience

An investigation of acute Physiological and Psychological Moderators of Psychedelic-induced Personality Change among Healthy Volunteers

This study investigated the effects of a single high-dose of psilocybin on personality traits in psychedelic-naïve healthy volunteers. These data orig…

sciencedirect.com

My full comments on the cuts to the Marsden Fund of the @royalsocietynz.bsky.social are now up here:

Govt cuts humanities and social science funding - Expert Reaction

Humanities and social science funding has been cut from the Marsden Fund, the main fund for 'blue-skies' research in Aotearoa New Zealand. The areas that have been cut include research in subjects lik...

sciencemediacentre.co.nz

Complexity in MEG/EEG. My prediction is that a good number of results are not actually showing changes in brain “complexity” but reflect spectral power changes - failing to use surrogate data properly. Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…

I’m not a sociologist but was introduced to this fabulous paper - Becker (1953) “Becoming a marihuana user”. Sometimes the archives of academia are amazing! www.jstor.org/stable/2771989

Becoming a Marihuana User on JSTOR

Howard S. Becker, Becoming a Marihuana User, American Journal of Sociology, Vol. 59, No. 3 (Nov., 1953), pp. 235-242

jstor.org

Psychopharmacology gets lots of criticism from psychotherapy/adjacent folks. But if someone could send me therapy trials that 1. Are double-triple blind 2. Carefully document/report AEs 3. Pre-register an SAP with ITT I would appreciate. I will wait ….

I feel my initial post on the Dodo bird may have been completely side-tracked into a debate on the MAPS model (which at the end of the day doesn’t much interest me)…. But at least some discussion because honestly blue sky has been kind of dull so far …

Suresh Muthukumaraswamy@sdmuthu.bsky.social · 2y ago

Been reading quite a bit of psychotherapy research lately. If one accepts the Dodo Bird Verdict (which is not an unreasonable position) then it really doesn’t matter what type of therapy is used in PAT (as long as not harmful) even if that therapy is based on odd principles …

Been reading quite a bit of psychotherapy research lately. If one accepts the Dodo Bird Verdict (which is not an unreasonable position) then it really doesn’t matter what type of therapy is used in PAT (as long as not harmful) even if that therapy is based on odd principles …

Re-posting this pre-print because a) New version b) Actually have followers on here now 😅 “Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms” Check it out. IMHO a unique project and I have learnt a lot from it. osf.io/preprints/ps...

Klein (1996). “The bottom line is that if the FDA was responsible for the evaluation of psychotherapy then no current psychotherapy would be approvable”. Dude didn’t hold back !

Seen Māori protests/haka on social media? Seen panels complaining of indigenous exclusion in psychedelic science? Check out our new pre-print: “Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms” osf.io/preprints/ps...

Keen to read but important to note his name was Albert, not Alfred, Hofmann...

an elderly man is sitting at a table holding a wallet and a credit card .

Alt: an elderly man is sitting at a table holding a wallet and a credit card .

media.tenor.com

After several years absence from social media I have returned. Perhaps only temporarily. We will see.