Sébastien Poulin
@sebpoule.bsky.social
Medical microbiologist & Infectious diseases MD @ St-Jérôme & Montréal, Québec, 🇨🇦 🔝 Interests HBV HDV HIV & General I.D. French 🇨🇦 with a 💩 accent #IDsky #HIVsky #Medsky
🔥🔥IDSA AMR Guidance 2026🔥🔥 🔺Notable Updates from the 2024 IDSA AMR Guidance Document 🔺Meropenem dosing update: individualized dosing approach (1–2 g IV q8h) with higher doses considered in selected clinical scenarios. #idsky www.idsociety.org/practice-gui...
Well, it finally happened. My first awkward Zoom moment. I was watching a pan-🇨🇦 post EASL meeting presentation (by CASL). I forgot to close my camera. I ended up bare chest while preparing a workout at home… in front of the « crowd » . 🤪😅🤦♂️🤷♂️
and Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial @thelancet.com #IDsky www.sciencedirect.com/science/arti...
sciencedirect.com
Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2mo ago🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
🔥Just published 🔥NEJM SNAP RCT In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky www.nejm.org/doi/full/10....
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia | NEJM
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...
nejm.org
Concomitant liver steatosis in chronic HBV infection is linked to a distinct cytokine profile and reduced viral load ✅ Just Accepted 🔗 https://bit.ly/4ejsct3
Important #HIV work by @frsimonetti.bsky.social and team. Here's a post by Dr Simonetti on LinkedIn👇 #IDsky ________________________________________ 🦀Time to celebrate🦀. Our study on #HIV non-suppressible viremia despite effective ART has been published in Nature Portfolio (Nat Comm).
Cancelled; Studies of Oral Weekly Lepetegravir (Formerly GS-1720) and Lenacapavir Pacfosacil (Formerly GS-4182); WONDERS-1 and WONDERS-2 ⬇️CD4 I won’t lie; I completely missed that. #IDsky #HIVsky www.fiercebiotech.com/biotech/gile...
Gilead cancels midstage HIV trial as FDA’s clinical hold remains intact
After the FDA placed two of its next-gen HIV drugs on clinical hold last June, Gilead Sciences has now terminated one of the affected trials. | After the FDA placed two of its next-gen HIV drugs on cl...
fiercebiotech.com
#EASL2026 «For the very first time in history, you saw a phase 3 trial with the endpoint S antigen (HBsAg) loss» -Dr @heinerwedemeyer.bsky.social about HBV B-Well phase 3 trials #IDsky
Lance Geiger: That Is History!
ALT: Lance Geiger: That Is History!
static.klipy.com
HBV Functional cure with Bepirovirsen B-Well 1 and B-Well 2 phase 3 studies ➡️ 24 weeks of Bepi s/c q1 week (all on NUCs) ~19% if qHBsAg <3000 ~26% if qHBsAg <1000 #EASL2026 #IDsky
Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection | NEJM
Treatment with bepirovirsen, an antisense oligonucleotide targeting hepatitis B virus (HBV) transcripts, has the potential to result in a functional cure, defined by at least 24 weeks of a sustaine...
nejm.org
🆕💥🔴Don’t Drop the B: Risk of Hepatitis B Virus Infection and Reactivation in the Era of Tenofovir-Sparing Regimens for Treatment and Prevention of HIV #idsky academic.oup.com/cid/article-...
Don’t Drop the B: Risk of Hepatitis B Virus Infection and Reactivation in the Era of Tenofovir-Sparing Regimens for Treatment and Prevention of HIV
Abstracts. Tenofovir-sparing antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) for human immunodeficiency virus (HIV) are increasingly used.
academic.oup.com
Top 20 Greatest Hits in HIV Medicine; Thank you Dr @paulsaxmd.bsky.social for your great Montreal 🇨🇦 presentation (special bonus; picture of young Dr Sax and colleagues)
Long time no see #IDsky Petechial hemorrhage in the palpebral conjunctiva of the lower eyelid … ❤️🩹Endocarditis (shared with patient consent)
🔥Late Breakers PeterPen RCT prelim results challenges carbapenem default in ESBL BSI Pip/tazo vs MER (EI) ✅Non-inferior 7d failure(29.4% vs 33.5%) ❌No early mortality signal 30d mortality 14.4%(interim) 👉Will mortality follow?MERINO taught us the hard way! #ESCMIDGlobal2026 #IDsky
▶️Optimising treatment of severe infections due to DTR organisms Bookmark this table, everyone's favorite table! #ESCMIDGlobal2026 #IDSky #EMIMCC
One-month treatment for latent tuberculosis. Why aren't we using it? (Hint: We should.) voices.nejm.org/doi/full/10....
One-Month Treatment for Latent Tuberculosis
Why aren’t we using it?
voices.nejm.org
Wrexham vs Chelsea 5th round FA cup 1-0 1-1 (own goal) 2-1 2-2 2-3 (Red card Wrexham) 3-3 (off side) 2-4 final Honestly, f*** yes Wrexham ❤️❤️❤️ Now, let’s go back to Championship playoff race. 11 fixtures We are at position #6 Hull city (#5) Tuesday Swansea city (#14) Friday … Let’s go! #askwxm
Omadacycline Monotherapy in NTM Pulmonary Disease Caused by Mycobacterium abscessus: Results From a Phase 2, Double-blind, Randomized, Placebo-controlled Study Compared to placebo, omadacycline monotherapy led to higher response rates Note: Lung Tx excluded academic.oup.com/cid/advance-... #IDSky
The just published TAPER-V trial has lots of fun journal club things to discuss: jamanetwork.com/journals/jam...
Initial Vancomycin Taper for the Prevention of Recurrent C difficile Infection
This randomized clinical trial tested whether a 4-week pulse and taper vancomycin regimen was superior to a 2-week pulse regimen for preventing recurrence among patients with a first episode or first ...
jamanetwork.com