Happy to share the first preprint out of the Nomburg lab! Many aspects of cellular immunity are shared across the tree of life. Here, we show that some of these conserved aspects of cellular immunity are mirrored by conserved effectors of immune antagonism. Thread below! 1/15

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2w ago

Conserved folds enable immune antagonism across the tree of life https://www.biorxiv.org/content/10.64898/2026.07.21.739742v1

Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!

Bacteria sense virus-induced genome degradation via methylated mononucleotides

Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

science.org

Osterman Ilya@ostermanilya.bsky.social · 4w ago

Excited to share that our Metis story is now published in Science! 🎉 Bacteria can sense phage-induced degradation of their genome and activate immunity. Many thanks to everyone who contributed to this work. 📄 www.science.org/doi/10.1126/... More details in my earlier thread 🧵⬇️

🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.

Igor Ulitsky@igorulitsky.bsky.social · 9mo ago

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

Despite EVERYTHING, we're still on for our annual Nucleic Acids Therapeutics next week at the Weizmann! There are still places to register (for free!), link in the first comment. Looking forward to meeting friends, great science, deep discussions, and great food, as always :-)

We are excited to share our new paper in Molecular Cell uncovering how the viral lncRNA RNA2.7 reshapes host cell biology! sciencedirect.com/science/authShare/S1097276526001565/20260324T143400Z/1?md5=16c84051c2f253c4665427f837a529d3&dgcid=author A thread 🧵

Tomorrow at the #SystemsVirologyJournalClub, @finkelyaara.bsky.social will present her work with @sginossarlab.bsky.social on engineering HCMV to express sgRNA libraries directly from the viral genome to profile virus-host interactions across the infection cycle. Join us!

Shira Weingarten-Gabbay@shiraweingarten.bsky.social · 10mo ago

🚨 Systems Virology Journal Club – 8th Series! 🚨 #BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨

Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx

N1-Methylpseudouridine directly modulates translation dynamics

Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.

rdcu.be

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

Structure-guided discovery of viral proteins that inhibit host immunity

Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

cell.com

Join our RNA Mediated Regulation of Immunity conference! Register until January 28th and access two conferences for the price of one, including Non-Coding RNA Biology. keysym.us/KSRNAImmune25 #KSRNAImmune25 #RNA #regulatoryRNA #immunology #immunity @sginossarlab.bsky.social

We're excited to announce the 2025 Nucleic Acid Tx meeting - on 5/2/25 at the Weizmann. Great speakers from academia/industry. Co-org with @sginossarlab.bsky.social @schraga.bsky.social Yaniv Erlich and Yogev Debbi. Abstract submission/free reg. link: bit.ly/3ODdRer