Faraz Mardakheh
@mardakheh.bsky.social
Associate Professor at the Department of Biochemistry, University of Oxford. Fellow of Brasenose College. Studying RNA binding proteins in cancer. https://mardakhehlab.info https://www.bioch.ox.ac.uk/research/mardakheh
Amazing news for the The Vaccine Identity Evaluation Consortium, which includes researchers from the Department of Biochemistry and partner institutions: a £3.7 million MRC DPFS grant to advance innovative technologies for detecting substandard and falsified vaccines. Congratulations 🙌 ⬇️
£3.7 million grant to advance devices for detecting substandard and falsified vaccines
The three-year project builds on research that began during the early months of the COVID-19 pandemic
bit.ly
Thanks Vaishali and @prelights.bsky.social for highlighting our recent work, spearheaded by the amazing @emiliealard.bsky.social! @oxfordbiochemistry.bsky.social @cancerresearchuk.org
Vaishali@vaishaligrewal.bsky.social · last wk.Check out my preprint highlight @prelights.bsky.social on the amazing work by @mardakheh.bsky.social and team! A pre-rRNA positive feedback loop drives malignant ribosome biogenesis prelights.biologists.com/highlights/a...
Check out my preprint highlight @prelights.bsky.social on the amazing work by @mardakheh.bsky.social and team! A pre-rRNA positive feedback loop drives malignant ribosome biogenesis prelights.biologists.com/highlights/a...
A pre-rRNA positive feedback loop drives malignant ribosome biogenesis - preLights
Tumor-driving signals turn pre-rRNA into a recruitment hub for the enzyme CK2, boosting nucleolar fusion and ribosome production
prelights.biologists.com
The AGO2 adaptor LIMD1 expands the functional and evolutionary reach of microRNA targeting | Science Advances www.science.org/doi/10.1126/...
The AGO2 adaptor LIMD1 expands the functional and evolutionary reach of microRNA targeting
LIMD1 helps AGO2 silence microRNA targets more effectively, revealing an additional layer of control beyond RNA sequence alone.
science.org
www.rnasociety.org/rna-society-...
RNA Society Public Statement on the Proposed OMB Rule Changes - RNA Society
The RNA Society is an international non-profit organization incorporated in the United States and dedicated to advancing RNA research and education. The Society is home to over 2,000 scientists (great...
rnasociety.org
Transformative work from the @mbarnalab.bsky.social Ribo-Tweezer enables direct interrogation of ribosomal protein (RP) function in mature ribosomes, revealing that distinct RPs control unique translatomes and that RACK1 removal rewires translation and stem cell identity. Congrats to all!
Maria Barna@mbarnalab.bsky.social · 3mo ago’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.
#RNAsky This time is us! 😁 Have a look at the new preprint from the @mardakheh.bsky.social lab! Immense body of work led by the fantastic @emiliealard.bsky.social that has mastered for this study no less than #proteomics #microscopy and complex #RNA assays. Best of all: findings replicate in mice!
Faraz Mardakheh@mardakheh.bsky.social · last mo.🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...
Thrilled that our new preprint is on bioRxiv! It’s been incredibly fun and rewarding working on this project throughout my PhD and PostDoc. I’m so grateful to our co-authors and funders for making this research possible, with the biggest thanks to @mardakheh.bsky.social for being the best mentor ✨
Faraz Mardakheh@mardakheh.bsky.social · last mo.🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...
🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15). 🔗 www.biorxiv.org/content/10.6...
🚨DON'T MISS IT! Less than 10 days to go before the abstract submission deadline for this AWESOME RNA conference in Newcastle with an amazing line-up👇 genetics.org.uk/events/rna-i...
RNA in physiology and disease | Genetics Society
Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...
genetics.org.uk
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
Very glad to have our latest study, led by the former stellar PhD student @pharrissnell.bsky.social and postdoc Parisa Naeli, out in @cp-cellreports.bsky.social. Translation-dependent regulation of stability of non-optimal mRNAs by 2 vertebrate-specific RBPs, ZC3H7A/B. www.cell.com/cell-reports...
Coordinated regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA-binding proteins
Harris Snell et al. report that ZC3H7A and ZC3H7B, two chordate-specific RNA-binding proteins, directly bind and coordinate the decay and translational regulation of A/U3-rich non-optimal mRNAs. By re...
cell.com
There are two types of people in the world: those who discovered Persepolis and were richer for the experience, and those that still have to. RIP Marjane Satrapi. www.lemonde.fr/en/obituarie...
Marjane Satrapi, author of 'Persepolis,' dies at 56
The French-Iranian artist and film director 'died of sadness a little over a year after the death of Mattias Ripa, her husband and the love of her life,' people close to her said.
lemonde.fr
Congratulations @robklose.bsky.social for being elected as a Fellow of the Royal Society! royalsociety.org/news/2026/05... great news to have two outstanding scientists, Rob and Colin, from @oxfordbiochemistry.bsky.social joining the Royal society today!
Exceptional scientists elected as Fellows of the Royal Society | Royal Society
Over 90 outstanding researchers from across the world have this year been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences.
royalsociety.org
Ribosome heterogeneity in E. coli : ribosomal RNA (rRNA) sequence and modifications, r-protein stoichiometry and PTMs, and ribosome-associated proteins pubs.acs.org/doi/10.1021/... 🦠
Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics
Characterization of large molecular machines, such as the ribosome, under a breadth of biological states to elucidate regulatory details remains challenging. Herein, a workflow combining complex-up na...
pubs.acs.org
Super happy to share the published version of our study: “Germline sequence variation within the ribosomal DNA is associated with human complex traits” in Cell Genomics www.cell.com/cell-genomic...!
cell.com
Pasteur Institute of Iran, founded in 1920 now destroyed by Israel-US bombing😞 It played a pivotal role in developing vaccines & public health services, for over a century, now gone😞 A few days ago a pharmaceutical plant was bombed, accused of making anesthetic fentanyl #War #PasteurInstituteIran
Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work! @oxfordbiochemistry.bsky.social www.nature.com/articles/s41...
Structural basis for prostaglandin and drug transport via SLCO2A1
Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...
nature.com
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...
Delighted to share our latest work in @narjournal.bsky.social on the importance of (lnc)RNA–protein interactions in cell division, and how we identified RSRC2 as a new RBP involved in splicing and centrosome-associated RNA localisation academic.oup.com/nar/article/...
RSRC2 is a novel RNA-binding protein that safeguards mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Abstract. Mitotic fidelity requires proper chromosome alignment at the spindle equator, a process known as chromosome congression, mediated by well-establi
academic.oup.com
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉 🔗https://doi.org/10.1016/j.celrep.2026.117109 #IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)
Redirecting
doi.org
Come work with Ben Berks FRS in Oxford 2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis 2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487) my.corehr.com/pls/uoxrecru...
my.corehr.com
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...
rdcu.be
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 - Nature Communications
LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...
nature.com
For those following the developments of research funding in the UK, here is another letter from Ian Chapman about UKRI: www.ukri.org/news/ukri-ce...
UKRI CEO updates the research community on areas of uncertainty
Following an open letter of 1 February, Sir Ian Chapman responds to feedback and provides an update.
ukri.org
A massive well done to our recently graduated PhD student and new postdoc @emiliealard.bsky.social for winning the RNA UK 2026 best talk prize🏆 👏👏👏#ProudPI #RNAUK2026
Join us; We have an opening for a BBSRC-funded 3-year postdoc position to investigate the mechanisms of mRNA-specific translational regulation of the innate immune system. #Postdoc #RNA #RBP #MolecularBiology #Virology #RNASky #AcademicJobs hrwebapp.qub.ac.uk/tlive_webrec...
Job profile
hrwebapp.qub.ac.uk
