Pervanadate: So much more than a protein tyrosine phosphatase inhibitor @babrahaminst.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
Sharpe Lab
@sharpe-lab.bsky.social
We investigate the functions of protein tyrosine phosphatases (PTPs) in redox signalling, cancer and immunology @babrahaminst.bsky.social #phosphatases #redox #kinases
Pervanadate is more than just a phosphatase inhibitor! Read our paper just published in #sciencesignaling showing that pervanadate oxidises and activates SRC kinase too. Link: tinyurl.com/5ype7e2s Thanks for the 'focus' by: @nshahlab.bsky.social tinyurl.com/54fcjds3 @babrahaminst.bsky.social
Pervanadate-induced oxidation relieves autoinhibition of the protein tyrosine kinase SRC
A widely used tyrosine phosphatase inhibitor also oxidizes and activates the tyrosine kinase SRC.
science.org
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
hireful.
tinyurl.com
We’re excited to share a new pre-print from the lab! Led by Carmen Ramirez Moncayo and a fantastic collaboration with several groups from across @mrc-lms.bsky.social & @imperialcollegeldn.bsky.social. Interested in #OvarianCancer, #PARPinhibitors or #DrugDistribution? please read on! bit.ly/45lpekS
'Rapper Rhodopsin' (AKA Ellie @trayon.bsky.social lab) and the Babraham Massive celebrating Ellie's victory in the first ever @eu-life.bsky.social Science Vision contest. We're so proud! Thanks @ceitec.eu - it was so much fun!
The @babrahaminst.bsky.social rock steady crew in Brno at the @eu-life.bsky.social Communuty Meeting
The @babrahaminst.bsky.social rock steady crew in Brno at the @eu-life.bsky.social Communuty Meeting
That's the end of the Signalling Symposium and the end of an era. To quote Phill's closing words: "It's been a hell of a journey." Thank you to everyone for attending and making it such a fitting tribute.
📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...
Cellular signals for health & disease
A symposium marking the contributions of Len Stephens and Phillip Hawkins
eventbrite.co.uk
If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
*Fully funded PhD position available in the lab* We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation. Please share, and email for details :) www.findaphd.com/phds/project...
BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool, listed on FindAPhD.com
findaphd.com
Join us in Würzburg, Germany, for the EMBO workshop “Phosphatases: From basic research to translation”! July 27-31 2025. Newest developments in the field, from academia and industry. Great networking opportunities! Short talk slots available. Hope to see you there! meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
www.nature.com/naturecareer...
Principal Investigators in Immunology - Babraham, Cambridge job with Babraham Institute | 12832167
The Babraham Institute in Cambridge, UK, invites applications for tenure-track and tenured group leader positions in the Immunology Programme. We w...
nature.com
New science leadership opportunities at the Babraham Institute
New science leadership opportunities at the Babraham Institute