The Department of Chemistry at the University of Pennsylvania invites applications for a tenure-track position at the rank of Assistant Professor in the broadly defined area of organic chemistry. I have the honor of chairing the search committee. apply.interfolio.com/192648

We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016

Come join us and our great students in Charleston! The CofC Dept. of Chemistry and Biochemistry is hiring a tenure-track assistant prof in organic chemistry. We STRONGLY encourage organic chemists across the discipline to apply! I'm happy to answer any questions #chemsky jobs.cofc.edu/postings/17937

Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).

Munson Lab | Home | BMB | UMass Chan Medical School

The Munson Lab researches the mechanistic basis for the regulation of spatial and temporal specificity in membrane trafficking in the Biochemistry & Molecular Biotechnology Department at UMass Chan Me...

umassmed.edu

Excited to share our lab's latest paper led by recent graduate Minhee Lee, PhD., out in its final form at ACS Chemical Biology! Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases pubs.acs.org/acbcct/artic...

Substrate-Derived Peptides for Selective Covalent Inhibition of Protein Tyrosine Kinases

AbstractProtein tyrosine kinases are important regulators of cell signaling, and aberrant kinase activity contributes to many human diseases, including can

pubs.acs.org

It's been a great couple of weeks for publications from the lab! First up we have a generalizable induced proximity system for gain of function PTM editing exemplified by acetylation and led by @briehp.bsky.social pubs.acs.org/acbcct/artic...

General Strategy for Controlling Functional Lysine Acetylation via Induced Proximity

AbstractAssigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events

pubs.acs.org

The NSF is on track to award 30% fewer new research grants this year—the lowest number in four decades. Basic science is the foundation of future medicines, technologies, and prosperity. We must fund it. www.nature.com/articles/d41...

Exclusive: NSF set to issue lowest number of new grants in four decades

The US science-funding agency is withholding $1 billion of its budget so that the money can go to a special White House project.

nature.com

Our paper on the active form of human protein kinases is out in Biochemical Journal from @biochemsoc.bsky.social . Great experience with the journal, unlike another journal that begins with "Nat" and ends with "omms." doi.org/10.1042/BCJ2... Made the cover in August (paper came out in July)...

Hey Chemists, we’re hiring, come join us! See the original post below, happy to answer questions. Charleston is a beautiful place to live, and we have great facilities, students, and colleagues! #chemsky @chemjobber.bsky.social

Mike Giuliano@drmikeg83.bsky.social · 2mo ago

Come join us! The CofC Dept. of Chemistry and Biochemistry is looking for a tenure-track assistant prof. in organic chemistry. We’re great place for undergraduate research, with superb facilities, great instrumentation for a PUI, and oustanding students! #chemsky jobs.cofc.edu/postings/18244

This piece really resonated with me - so often I've wished I could go back and assure my younger self that things will (mostly) work out: www.science.org/content/arti...

To my younger self, the overwhelmed new professor: You will make it

How this scientist navigated the tough decisions and personal strain of starting a lab

science.org

Congrats to Dr. Andrew Johns, the 7th PhD from our lab! He gave a great talk describing his project on using photo-crosslinking to identify tyrosine phosphatase substrates. His work dropped on bioRxiv yesterday: bsky.app/profile/nsha...

Neel Shah@nshahlab.bsky.social · 3mo ago

Excited to share this new preprint, led by graduate student Andrew Johns! We used amber suppression to install photocrosslinkers in PTP1B to enable identification of new substrates. Our method detects localization- and stimulation-dependent changes in substrate scope. www.biorxiv.org/content/10.6...

Excited to share this new preprint, led by graduate student Andrew Johns! We used amber suppression to install photocrosslinkers in PTP1B to enable identification of new substrates. Our method detects localization- and stimulation-dependent changes in substrate scope. www.biorxiv.org/content/10.6...

In situ identification of substrates of the protein tyrosine phosphatase PTP1B using site-specific photo-crosslinking

Protein tyrosine phosphorylation is critical for cellular function, and aberrant phosphorylation is tied to a wide range of human diseases. Identifying the substrates of protein tyrosine phosphatases,...

biorxiv.org

Wow, this looks awesome and will be a great resource to anyone studying protein-protein interactions, SLiMs, and cell signaling! Excited to dig into this. Congrats to everyone involved!

Ylva Ivarsson@ivarssonlab.bsky.social · 3mo ago

Excited to share our preprint introducing ASHI: the Atlas of SLiM-mediated Human protein-protein Interactions. By screening 800+ domains against the human intrinsically disordered regions, we map 20,000 SLiM-mediated interactions. Many thanks to everyone involved! www.biorxiv.org/content/10.6...

“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...

Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

inpreparation.substack.com

Please share this gift article from The New York Times with friends, family, sceptics, and People who think that studying weird things is a waste of money. Then follow up with meaningful discussion about what I call 'free range science'. Free without subscription. www.nytimes.com/2026/06/20/o...

Opinion | The Science That Turned Lizard Venom Into GLP-1s Is Under Attack

nytimes.com

I love New York.

Congrats, Weeks lab! Very enabling platform and a cool study!

Amy Weeks@amyweeks.bsky.social · 3mo ago

Now online @pnas.org: We developed a simple, scalable, and accessible platform for deep profiling of phosphoeraser specificity using human phosphoproteome-derived peptide libraries (PhosPropels!) 🧪👩‍🔬https://www.pnas.org/doi/10.1073/pnas.2523183123

New crew, new photo, still awesome to work with!

Happy to introduce PhD #6, aka Dr. Minhee Lee! He gave a fantastic talk today and did a great job defending his dissertation!

Are you interested in understanding protein dynamics and allostery in biomedically relevant "loopy" enzymes? We are looking for postdocs to join our group at GT for both applied and method development work. If you are interested, please email me your CV, cover letter, and details of 2-3 referees.

⌛ Don’t miss the June 1 registration deadline for #ProteinPhosSRC! This conference brings together scientists from around the world to share new discoveries in protein phosphorylation, disease mechanisms, and therapeutic development. Register now! buff.ly/YxSgh5Y

We are hiring! This is a joint Lab Assistant position with @phosphotig.bsky.social ‘s lab. If you are organized and creative, enjoy learning new things, and if working with two great teams of scientists sounds appealing, please apply! unc.peopleadmin.com/postings/319...

My department is open to hosting a Starting Grant lab. If you are eligible and want to do biochemistry broadly defined (we like everything, from biophysics to systems biology!) consider applying. My department is the best and Zurich is pretty good too! www.nature.com/naturecareer...

Assistant professor for ERC Starting Grant in Biochemistry - Zurich (CH) job with University of Zurich (UZH) | 12859194

Assistant professor for ERC Starting Grant in Biochemistry (non-tenure track)

nature.com

Happy to share this paper from our lab, with @jlmcfalinefigueroa.bsky.social’s group, out in its final form at Science Advances! Big congrats to lead authors Anne van Vlimmeren and Ross Giglio! www.science.org/doi/10.1126/...

Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants

RNA sequencing of cells expressing SHP2 disease mutants shows how changes to enzyme structure cause different cellular outcomes.

science.org

Neel Shah@nshahlab.bsky.social · last yr.

Check out our latest preprint, from Anne van Vlimmeren in my group and Ross Giglio in @jlmcfalinefigueroa.bsky.social's lab. We used single-cell transcriptomics, biochemistry, and structural analysis, to reveal how mechanistically distinct SHP2 disease mutations yield different cellular states.

New research from the @jlmcfalinefigueroa.bsky.social and @nshahlab.bsky.social groups, recently published in Science Advances, uncovers novel mechanisms by which SHP2 mutations disrupt cellular processes. This work may help pave the way toward future therapies for patients > bit.ly/4nGsVZm

Excited to share our lab's latest preprint, led by graduate student Minhee Lee, with contributions from former undergrad Zijing Wang and grad student Andrew Johns! We show that substrate specificity information coupled with AF3 models can be used to design selective tyrosine kinase inhibitors.

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · 4mo ago

Substrate-derived peptides for selective covalent inhibition of protein tyrosine kinases https://www.biorxiv.org/content/10.64898/2026.05.11.724146v1

Happy to share the final version of this work is now out in @natchembio.nature.com. Lots of additional exciting data! Congrats to all the authors!

Posttranslational modifications remodel proteome-wide ligandability - Nature Chemical Biology

A chemoproteomic strategy reveals how posttranslational modifications reshape protein ligandability across the human proteome, uncovering more than 400 state-dependent interactions, including phosphor...

nature.com

Chris Parker@chrisgparker.bsky.social · last yr.

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...

PhD student or Postdoc (f/m/d)- Understanding and manipulating ubiquitin ligase specificities -

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...

mpinat.mpg.de

Excited that our paper on enzymatic bromination of peptides is now online at ACS Chemical Biology! Led by Haley Bridge, we showed that the flavin-dependent halogenase RebH and its variants can be used for late-stage chemoenzymatic diversification of bioactive peptides: pubs.acs.org/doi/10.1021/...

Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling

Flavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li...

pubs.acs.org

🏆 2026 Protein Society Award Winners Celebrating the scientists shaping the future of protein science 👏 🎤 Hear from this year’s award winners live at #PS40 in Boston this July 🔗 Learn more + register: proteinsociety.org/annual-symposium #TheProteinSociety