We knew Toxoplasma Type I needs fats to survive in culture. Now we show this in Toxoplasma Type II, responsible for most human infections in Europe and North America. Blocking fatty acid elongation reduced growth and persistence in lab culture and in animals. www.biorxiv.org/content/10.6...

Calling all parasite enthusiasts in and around Scotland 👇

SPPIRIT Network@sppirit-network.bsky.social · 5mo ago

Join us on March 20th, 3 pm British time for SPPIRIT Forum meeting! We will explore the differences in research of different parasites, from the techniques available to day-to-day lab work, with our invited speakers, covering kinetoplastids, apicomplexans, and schistosoma. Register on link below:

Care for some #toxoplasma with your beer? @colbertlateshow.bsky.social bear-poop-beer report is making toxoplasma great again

Thank you Philippe, I had an excellent and inspiring day!!

Philippe Bastin's Lab@bastinlab.bsky.social · 6mo ago

Fantastic talk of @sheinerlab.bsky.social today @pasteur.fr about these crazy ribosomal mitochondrial RNAs in #Toxoplasma!

If you are a committed scientist who wishes to work with Toxoplasma or with organelles (or both!!) - come work with us: www.jobs.gla.ac.uk/job/research...

Perkinsus marinus is an important marine pathogen yet we know little about its biology. @macleanlab.bsky.social reports here complexome work of whole parasite and mitochondria mapping the essential mitochondrial enzymes and kickstarting future functional studies. www.biorxiv.org/content/10.6...

Complexome profile of mitochondrial complexes in the myzozoan parasite of oysters, Perkinsus marinus

Mitochondrial complexes, such as the mitochondrial electron transport chain (mETC), the F1Fo-ATP synthase and the mitochondrial ribosome, are centrally important for mitochondrial function. Recently, ...

biorxiv.org

Had a great time interviewing Dr. Lilach Sheiner (@sheinerlab.bsky.social) for the latest edition of ISOP’s Protistology Newsletter. Check it out here! #ProtistsOnSky #Toxoplasma #Science

ISOP member spotlight Lilach Sheiner

YouTube video by Protistologists

youtu.be

Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified. www.biorxiv.org/content/10.1...

🎓 Funded #PhD studentships in pathogen biology and parasitology *Cell and Molecular Biology*; *Host-pathogen interactions* Part of the EastBio Doctoral Landscape Award Based in the Edinburgh area of Scotland PhD 1: bit.ly/Host-pathoge... PhD 2: bit.ly/Parasite-sca... @uoe-eid.bsky.social

EastBio: A host-directed approach to identify novel therapeutic targets of infectious reproductive diseases at Moredun Research Institute on FindAPhD.com

PhD Project - EastBio: A host-directed approach to identify novel therapeutic targets of infectious reproductive diseases at Moredun Research Institute, listed on FindAPhD.com

findaphd.com

and meet the @sppirit-network.bsky.social dream team that made it all happen! Follow the for more (a new #Postdoc fellowship workshop coming up!!)

SheinerLab@sheinerlab.bsky.social · 9mo ago

Busy and exciting poster session @sppirit-network.bsky.social conference. SheinerLab's Anil and Victor spotted checking out some cool work!

Coming up: Postdoctoral fellowship mini-workshop as a part of the SPPIRIT Forum series. EMBO, Marie Curie, and Wellcome Early Career fellows will share their advice on fellowship applications. Join us at 12 noon on Thursday 14th November! Register at docs.google.com/forms/d/e/1F...

Jana getting everyone into #membranes at @sppirit-network.bsky.social conference.

An official new measuring unit for the parasitology community had emerged from this @parafrap.bsky.social #EMBO conference... #shitton @nicolas3474.bsky.social @kirkdeitsch.bsky.social

Fabulous work from @nicolas3474.bsky.social on the protein atlas of the molluscs parasite #Perkinsus @parafrap.bsky.social

Wonderful session on @parafrap.bsky.social parasites pathogenesis chaired by @apicolipid.bsky.social @clarehardinglab.bsky.social

The science at #ParaFrap is exciting and surprising as always - less surprising: who are the last people standing on night #1 ... @freddyfrischknecht.bsky.social @kirkdeitsch.bsky.social

Kick-off of @parafrap.bsky.social #EMBO conference at #LesEmbiez by the wonderful organisers @gloverlab.bsky.social and Benoit Gamain who put together an exciting program about parasite biology, epidemiology and combat.

We have a project advertised as part of the @NorthWestBio1 program this year - come join us! www.gla.ac.uk/postgraduate... Applications to the program are here: www.gla.ac.uk/postgraduate...

Congratulations Saniya for graduating her PhD!!!

Calling all mitochondria enthusiasts, we are recruiting for a new project (and the post will be split between Glasgow and Helsinki) www.jobs.gla.ac.uk/job/research...

The trypanosomal TAC is required for mitochondrial DNA segregation. We provide insight into TAC assembly: one of the most extreme sorting event for any mitochondrion. Congratulations to Philip, Salome and Bernd #mitochondria #mtDNA #Trypanosoma journals.plos.org/plospathogen...

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex

Author summary Mitochondria are essential for nearly all eukaryotes. This requires proper segregation of the organelles and their genomes to the daughter cells during cell division. For Trypanosomes a...

journals.plos.org

Team bioenergetics in divergent organisms is ready to go! #ICOP25 @macleanlab.bsky.social @lettsscience.bsky.social

A first #ICOP25 day 2 highlight: Dayana Salas-Leiva of Ross Waller's lab uses LOPIT to ask not only what makes a symbiotic relationship, but what baggage is left after a break-up. Stay tuned!

#ICOP25 opened today with so many exciting eukaryotic microbe insights 🦠 - you know its gonna be a great one when it starts with a drown video 😉 Stay tuned!!

Happy to have contributed to this wonderful study about #Toxoplasma #supercomplex led by @macleanlab.bsky.social, @sheinerlab.bsky.social and Alex Mühleip. Parasite mitochondria never cease to amaze! Please go checkout 👇

Andrew Maclean@macleanlab.bsky.social · last yr.

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group. www.nature.com/articles/s41...

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group. www.nature.com/articles/s41...

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology

Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

nature.com

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Andrew Maclean@macleanlab.bsky.social · last yr.

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group. www.nature.com/articles/s41...

Excellent to take part in a round table focus on African partnerships within our Glasgow Changing Futures strategy @uofgsii.bsky.social @uofglasgow.bsky.social

As Sheinerlab is joining the trend, Chat seem to have known that @macleanlab.bsky.social started his own lab recently and took the executive decision to remove him from the photo 😲😆

A true honour. Thank you to BSP @bspparasitology.bsky.social and our fabulous parasitology community

University of Glasgow School of Infection & Immunity@uofgsii.bsky.social · last yr.

🏅 | @uofgsii.bsky.social's Professor Lilach Sheiner (@sheinerlab.bsky.social) was recently awarded the prestigious C.A. Wright Medal by the @bspparasitology.bsky.social for outstanding contributions to the discipline. Congratulations, Professor Sheiner! 🔗 Full story: www.gla.ac.uk/schools/infe...