Andrew Maclean
@macleanlab.bsky.social
MRC research fellow at the University of Edinburgh working on parasite metabolism.
Meet Holdonia, a new member of the chrompodellid clade. Found clinging to a polychaete, this little guy reveals that similar patterns in plastid reduction have occurred independently across chrompodellid and related lineages. @rhizalyssa.bsky.social @pjkeelinglab.bsky.social tinyurl.com/2t25xb6z
The evolutionary transition from alga to parasite in the sister lineage of apicomplexans
The chrompodellids are a collection of photosynthetic “chromerids” and heterotrophic “colpodellids,” which are together the sister lineage to the apic…
tinyurl.com
🆕 | @uofgsii.bsky.social Research Fellow Dr Megan Sloan has been awarded a 2026 @sulsa.bsky.social Postdoctoral Prize for work showing excellent potential to make an impact in the field of life sciences. 🔗 Full story: www.gla.ac.uk/schools/infe... 📺 SULSA video: youtu.be/nJASKkxqMpA?...
Hi all, I'd like to share some news - I will soon be moving to Lisbon, Portugal to start my very own lab @gimminstitute.bsky.social! The Epithelial Biology of Apicomplexan Infections lab (Epi-Api lab for short) will focus on the special relationship between #epithelial cells and #Cryptosporidium.
This week, our paper came out in @jem.org showing that: This week, our paper came out in @JEM showing that: 1. Long-lived Tim-4+ macrophages are present in the lamina propria and submucosa/muscularis. 2. Macrophage-derived TGF-beta is key to instructing macrophage identity in the lamina propria.
New study from Jayaraman, Prise, et al. from the Grainger & @tovah-shaw-lab.bsky.social labs @edinburghbiology.bsky.social @lydiabeckeriii.bsky.social challenges the prevailing paradigm that long-lived gut #macrophages are restricted to the muscularis. rupress.org/jem/article/...
Our work just came out today in print form in Nat Micro. Really a tour de force from Hisham Alrubaye on sexual development in Toxoplasma gondii. Well done! rdcu.be/feOj6
A single-cell atlas of Toxoplasma sexual development in the feline intestinal tract
Nature Microbiology - Single-cell RNA sequencing is used to study the sexual development of Toxoplasma gondii in cats, generating a transcriptional atlas and showing that the female-specific gene...
rdcu.be
Our last manuscript is out! 🚨 We identify double stranded RNAs in embryonic stem cells - full of transposons, especially young LINEs and LTRs 🧐 🧬Happy Friday Reading🧬
biorxiv.org
Thank you so much to everyone who made it to #BSP2026 in beautiful, sunny Glasgow!!! (We asked the weather to behave while everyone was around)! The @bspparasitology.bsky.social 2027 meeting will be in Cardiff! I hope everyone enjoyed themselves! Like Glasgow, People Make #Parasitology! 🥳🧬🧫🔬
Come and find us at @bspparasitology.bsky.social #BSP2026! 👋 Find out about our upcoming events, share your feedback, and see how you can get involved with the committee. And if nothing else... our goodies might just tempt you 😉
We open with @sheinerlab.bsky.social introducing a scientist who needs no introduction - Dominique Soldati-Favre. Dominique was awarded lifetime membership to the @bspparasitology.bsky.social for her immeasurable contributions to the field. #bsp #parasites #peoplemakeglasgow
Our Spring meeting starts today in Glasgow! All the best to all those presenting @bspparasitology.bsky.social
New preprint! We identified many components that localize to the structure involved in "eating" in a marine organism. #ProtistOnSky #diplonemid www.biorxiv.org/content/10.6...
biorxiv.org
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...
Job opportunity for a #FlowCytometry technician, School of Biology, University of Edinburgh, UK. We do cool flow with fungi, bacteria, diatoms, space particles, as well as mammalian cells. Spectral, conventional and sorts. Join us! Details here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Flow Cytometry Technician
We are looking for an enthusiastic person to join the flow cytometry facility in the King’s Buildings campus at the School of Biological Sciences in the University of Edinburgh. This role involves pro...
elxw.fa.em3.oraclecloud.com
Honored and proud to be elected EAM member. Huge thanks to mentors, my amazing team (past&present), the great parasitology community @parasitesrule.org @parafrap.bsky.social for support throughout this journey @inserm.fr @cnrs.fr @umontpellier.bsky.social @erc.europa.eu @frm-officiel.bsky.social
It feels cheesy when people say this but it really was a privilege to be part of this work. Our recent paper (led by the fantastic Ben Royer @swallacelab.bsky.social) shows how engineered Ecoli can turn the main product of PET plastic breakdown it into an anti-Parkinsons drug (L-DOPA) rdcu.be/e84ZO
Microbial upcycling of plastic waste to levodopa
Nature Sustainability - The production of high-value chemicals can involve energy-intensive processes, necessitating sustainable production strategies. Here the authors present a circular...
rdcu.be
🆕 | Sii's Dr Mariana Ferreira Silva has been awarded a Young Investigator Grant from FAPESP to establish a research group at the University of São Paulo. The group will investigate how the ubiquitination system contributes to the Toxoplasma gondii life cycle. 🔗 More: www.gla.ac.uk/schools/infe...
Like #hemocytes? I'm advertising a 3 year, BBSRC #postdoc position, in #Edinburgh, using #Drosophila & human cells to understand sex differences in the regulation of #macrophage function, an exciting collaboration with the Bénézech and Wood labs. Please share! 🪰🏴 www.jobs.ac.uk/job/DQU604/p...
Postdoctoral Research Associate at The University of Edinburgh
Discover an exciting academic career path as a Postdoctoral Research Associate at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
jobs.ac.uk
Join us next Friday to learn about working with different parasites and enhance your parasitology network!
Join us on March 20th, 3 pm British time for SPPIRIT Forum meeting! We will explore the differences in research of different parasites, from the techniques available to day-to-day lab work, with our invited speakers, covering kinetoplastids, apicomplexans, and schistosoma. Register on link below:
Happy to announce a new review article by MD/PhD student Kade Loveridge on iron metabolism in #malaria #parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social @parasitesrule.org journals.plos.org/plospathogen...
Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites
Plasmodium falciparum parasites cause severe human malaria and depend on iron for essential metabolic processes during all phases of their complicated lifecycle, including when growing in human red bl...
journals.plos.org
📆 Join us for the scientific session of the ParaFrap Next Generation in Parasitology Workshop (May 18-21, 2026, Montpellier) ! 🧑🔬 Junior PIs will present their work. Registration is free but mandatory (includes lunch & coffee breaks). Spots are limited, register now! 👉 forms.gle/bYsb47iZG7pR...
A great collaboration of my group with @herassr.bsky.social and @heick.bsky.social groups searching for mammalian dsRNAs and their importance to human disease 🧬
I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NAR
🚨 Postdoc position 🚨 I’m moving back to Switzerland this summer to launch my lab at the University of Zurich and am recruiting a Postdoctoral Fellow (start: late 2026). Details & application: jobs.uzh.ch/job-vacancie.... Please share! 😊
UZH: Postdoc
The newly founded Cryptosporidium lab at the Institute of Parasitology focuses on the genetic and transcriptomic basis of parasite virulence and persistence in Cryptosporidium and is committed to incl...
jobs.uzh.ch
Want to computationally analyse a genome's-worth of protein localisations? Have data for 4.5 million cells at your fingertips using this Python tool to access TrypTag.org data www.biorxiv.org/content/10.6... (we're out of beta and releasing on time 🎂)
biorxiv.org
Very excited to share our work, a fish herpesvirus' cryo EM structure. It features a long PVAT tail, with new and host-like proteins discovered using modelAngelo, Dali, and Viro3D, including a host-like macrodomain doi.org/10.64898/202... @dbhella.bsky.social @grovearmada.bsky.social
doi.org
I am excited to share our latest preprint - An evolutionarily divergent herpesvirus with a giant tail. Featuring symmetry breaking and genome annotation from structure using ModelAngelo. doi.org/10.64898/202...
Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key #ubiquitin recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust #PlantImmunity👇🏾
Ubiquitin recognition integrates plant immune signaling by cell-surface and intracellular receptors https://www.biorxiv.org/content/10.64898/2026.02.06.703835v1
Spatial Proteomics Workshop for Protists (see more in thread below) Registration Early Bird Monday 22nd June 2026. Regular Monday 10th August 2026. There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...
Congratulations to Barrack, we are very excited to welcome him here in Edinburgh.
Congratulations to Barrack Owino on passing his PhD viva! Barrack used a range of our LM and EM systems to do his research on Leishmania. We will miss you Barrack; @macleanlab.bsky.social you've gained a gem!