🚀 New updates improve metalloprotein data across the PDB Archive. ~15,500 PDB entries and ~900 metal-containing CCDs now feature more complete chemical descriptions and metal coordination annotations. ⬇️More ⬇️ www.wwpdb.org/news/news?ye... #PDB
New #ISEPpapers #Preprint! #CRISPR / Cas9 #GeneEditing in the heterotrophic protist #Acanthamoeba castellanii www.biorxiv.org/content/10.6... #Protists #Microbes #Parasites #ProtistsOnSky
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
🚀 Preprint alert: cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle #CryoEM Explore how cFAR, tFAR, and Relative Signal provide complementary diagnostics for preferred orientation, tested across 14 #EMPIAR datasets and compared with established metrics 👉 bit.ly/4wBY1Ev
Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at @mrclmb.ac.uk 15 y ago! www.biorxiv.org/content/10.6... @szokoli.bsky.social Jason Hingey, Dan Haack, Vivian Wu Nick Spellmon @navtejtoor.bsky.social @hhmijanelia.bsky.social
Excited to share what I've been working on with an incredible team! Visualisation of Asgard viruses on cell surfaces and vesicles, and a story of complex viral interactions. Preprint: www.biorxiv.org/content/10.6... @brendanburns999.bsky.social @belindaferrari.bsky.social @xabivc.bsky.social
Conformational gating at histidine junctions coordinates proton translocation in respiratory complex I www.biorxiv.org/content/10.64898/2026.08.12.744383v1 #cryoEM
New #ISEPpapers! An endogenous energy-metabolizing organelle www.cell.com/current-biol... #Protists #Microbes #Organelles #Evolution
Why a Chloroplast Needs Its Own Genome Tethered to the Thylakoid Membrane—Co‐Location for Redox Regulation - Allen - 2026 - BioEssays - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Why a Chloroplast Needs Its Own Genome Tethered to the Thylakoid Membrane—Co‐Location for Redox Regulation
A schematic outline of chloroplast DNA tethered to two stacked thylakoids that contain the components of photosynthetic electron transport. Green shapes represent proteins encoded in chloroplast DNA;...
onlinelibrary.wiley.com
Interested in a career in industry cryoEM? We're hiring! We seek a cryoEM/cryoET expert to join our team at Genentech advance our mission to provide high-resolution structural insights into biological macromolecules involved in health and disease. Apply at: careers.gene.com/us/en/job/20...
Systems Specialist II in South San Francisco, California, United States of America | Manufacturing & Engineering at Genentech
Apply for Systems Specialist II job with Genentech in South San Francisco, California, United States of America. Manufacturing & Engineering at Genentech
careers.gene.com
🧬🌱 Algal chloroplast ribosomes have a unique arm domain, revealed by cryo-ET and cryo-EM. It may stabilize mRNA and organize polysomes. Chloroplast translation is more structurally diverse than expected. #plantscience @natplants.nature.com www.nature.com/articles/s41...
Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants
Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...
nature.com
Are you an ecologist/evolutionary biologist looking for an ongoing academic position? Monash University’s School of Biological Sciences is hiring! Come join us in Melbourne, Australia! Details here: careers.pageuppeople.com/513/cw/en/jo...
Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...
Jobs - The University of York
jobs.york.ac.uk
I am honored. So many of my scientific heroes are ASCB fellows. Thanks to my nominators, my mentors, and to UC Davis ASCB fellows Mark Winey, Jon Scholey, and Jodi Nunnari. But thanks most to all those who have done science with me, @gwgl.bsky.social and all the graduate students and postdocs
American Society for Cell Biology@ascbiology.bsky.social · last mo.Congratulations to the 2026 ASCB Fellows! ASCB is proud to recognize 15 scientists whose careers have advanced cell biology through outstanding research, leadership, mentorship & service. Meet the 2026 Fellows: https://www.ascb.org/society-news/fifteen-visionary-scientists-named-2026-ascb-fellows/
One cell, one tomogram! Our montage tomography workflow, MOSAIC, is out in Structure, and MontageMaker is on GitHub! MOSAIC: www.cell.com/structure/fu... MontageMaker: github.com/MPI-Dortmund... Big thanks to @maikaboiero.bsky.social, Adriana Prajica, Gavin Rice, and @raunser-lab.bsky.social!
This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏
Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants
Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...
nature.com
Florent Waltz@florentwaltz.bsky.social · 7mo agoLong in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵
The mitochondria are the powerhouse of the cell — and according to biologist Martin Picard, they’re also the link between biology, health, and the mind. In other words, the foundation of our experience being alive. www.quantamagazine.org/martin-picar...
Martin Picard’s Mitochondrial Theory of Mind | Quanta Magazine
The biologist’s bold “energetic view of life” looks to the body’s strangest organelles as the link between cells, health, and mind and the foundation of our experience of being alive.
quantamagazine.org
I'm excited to announce a new preprint from the lab just posted to bioRxiv: “Retrograde trafficking inhibitors allosterically trap Get3 to block tail-anchored protein biogenesis.” www.biorxiv.org/content/10.6...
How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.
Excited to share my paper! 🥳 Today in #Nature we reveal an 8 MDa Hdr electron bifurcating super-assembly in class I methanogens that couples the first and last steps of hydrogenotrophic methanogenesis. A lineage-specific adaptation to anaerobic niches. www.nature.com/articles/s41...
1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...
CryoSPARC workshop in Toronto! Beyond consensus refinements: Advanced cryo-EM data processing with CryoSPARC Sept 24-25, 2026 (part of the Canadian Cryo-EM Nexus) Register here: cvent.me/dL1wem Please see details in the link or the image Alt text @structurabio.bsky.social @sickkidsto.bsky.social
“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬
Philippe Van der Stappen@phaips.vd.st · last yr.Hey #TeamTomo, Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging? That's why @florentwaltz.bsky.social and I made this website! tomoguide.github.io Follow the thread 1 /🧵 #CryoET #CryoEM 🔬🧪
How did complex cells emerge? In this groundbreaking paper, @tonigabaldon.bsky.social & co show that eukaryotes arose through multiple waves of ancient genetic exchange involving diverse bacteria (& giant viruses!) revealing a far more complex origin than we imagined. www.nature.com/articles/s41...
Exciting work from the Maldonado lab (formerly of @ucdavis.bsky.social , now at @monashuniversity.bsky.social) The first structure of Photosystem I from giant kelp! www.monash.edu/news/article...
New research suggests giant kelp could inspire innovative climate solutions
New research reveals the microscopic machinery that helps giant kelp turn sunlight into energy, providing inspiration for innovative new climate solutions.
monash.edu
We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
Nature research paper: Early fossil eukaryotes were benthic aerobes go.nature.com/3Rdw9rk
Early fossil eukaryotes were benthic aerobes - Nature
Integrated palaeontological, sedimentological and geochemical analyses of ancient rocks from Australia show that early eukaryotes were largely restricted to oxygenated benthic habitats, probably possessed mitochondria by 1.75 billion years ago, and may have expanded into planktonic habitats much later, perhaps during the Neoproterozoic era.
go.nature.com