Our paper showing that acquired resistance to CDK inhibitors can result from simple mutations in the CDK gene is now out - thanks to Chun-Fui Lai, @vcushing.bsky.social @bjgreber.bsky.social with support from @prostatecanceruk.bsky.social @imperialsandc.bsky.social www.embopress.org/doi/full/10....

Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells | The EMBO Journal

imageimageCDKs control cell cycle progression and transcription, pathways commonly dysregulated in cancer. This study identifies a resistance mechanism of prostate cancer cells towards the CDK7 inhibi...

embopress.org

More than just a bad apple: why we must look closer at the Nathan Gill scandal New evidence connects the Ukrainian politician who paid bribes to Gill - Reform UK’s former leader in Wales - to a campaign to destabilise the US election @carolecadwalla.bsky.social reports

Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer? A brilliant team led by @simak.bsky.social @imperialcollegeldn.bsky.social share exciting new findings in @embojournal.org. Grab a ☕ and read: doi.org/10.1038/s443...

We show a single amino acid change in CDK7 causes acquired resistance to CDK7i in cancer cells. There are implications for patient selection,resistance monitoring and switching treatments. thanks to @vcushing.bsky.social @bjgreber.bsky.social @prostatecanceruk.bsky.social doi.org/10.1038/s443...

This will be a great meeting - and in the sunniest part of the UK!

The British Association for Cancer Research@thebacr.bsky.social · last yr.

Cancer Immunology - Final Reminder for Abstract Submission: 11th July 2025

www.nature.com/articles/s41... A fantastic paper on the dynamics of the estrogen receptor N-terminal domain. A big win for the field and the Yang lab should be commended on their seminal study!

The sequence–structure–function relationship of intrinsic ERα disorder - Nature

Serine 118 phosphorylation drives conformational changes through the disruption of hydrophobic interactions between aromatic-rich clusters, showing how hydrophobic mutations can restore oestrogen rece...

nature.com

Our publication in Cancer Research (DOI: 10.1158/0008-5472.CAN-24-0013) reveals a route to hormone therapy resistance in #ER-positive breast cancer patients. We show that induction of #VGLL1 drives gene expression programmes that confer resistance to ER degraders.

#science #cancer #breast_cancer #hormone_therapy #transcription

Simak@simak.bsky.social · 2y ago

Our work flags new therapeutic opportunities for patients who progress on/after hormone therapies, including VGLL1/TEAD inhibitors & drugs targeting EGFR Thanks to a super collaboration with @magnanilab.bsky.social, funding from @cancerresearchuk.org and support from @imperialsandc.bsky.social

Applications for Endocrine Society's awards programs are open until 1/15, including key early career programs, e.g. Early Career Forum & REGMS research fellowship. These programs are a gateway to grow careers in endocrinology and in ES as a professional home. Apply today! www.endocrine.org/awards

Our publication in Cancer Research (DOI: 10.1158/0008-5472.CAN-24-0013) reveals a route to hormone therapy resistance in #ER-positive breast cancer patients. We show that induction of #VGLL1 drives gene expression programmes that confer resistance to ER degraders.

Super lineup for this conference.

Yaser Atlasi@yatlasi.bsky.social · 2y ago

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

Almost 1 month left to submit your abstract for the #Epigenetics2025 conference, organized by @gensocuk.bsky.social We’ve put together a fantastic scientific program, and Northern Ireland is a wonderful destination to explore.

Yet….. It seems from the data that there is a tendency for better efficacy in CDK4/6i-first. But the p-value is 0.1… what if the n were bigger? The tyranny of the p-value? #oncoSky #oncosky🧪

Marcos Malumbres@mmalumbres.bsky.social · 2y ago

Exciting news in cancer therapy! The order of drugs impacts the duration of treatment, toxicity, and economic cost. A necessary example of how relevant academic, self-funded trials are!! Breast #cancer #oncosky #oncsky #medsky 🧪 @natureportfolio.bsky.social www.nature.com/articles/d41...

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

nature.com

📢 Looking for a #postdoc position in the intersection of #cancer, #chromatin and #epigenetics??? Still a few days left to apply to our lab in wonderful Denmark as part of the new translational cancer hub initiative🇩🇰🧪👇🏻

In other news millions of people in the UK are living in poverty, destitution & using food banks

From these data, we derived the mechanism of CDK7-selectivity of the clinical compound and formulated a hypothesis for a secondary mechanism of selectivity in this compound class. We tested this hypothesis successfully by analysis of the compound CT7030.

Ok first post on Bluesky and it’s a science one… New paper out from the lab! APOBEC genes protect us from viral infection but go rogue in cancer. Here we shed new light on how these important genes are regulated, offering clues as to what goes wrong in cancer. www.embopress.org/doi/full/10....

Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma | The EMBO Journal

imageimageAPOBEC3A and APOBEC3B encode DNA editing enzymes with anti-viral roles that generate somatic mutations in cancer. This study provides insight into their expression in healthy and cancerous e...

embopress.org

It’s so important we support @bylinetimes.bsky.social. It’s the newspaper we’ve all been waiting for. Truly independent journalism at its very best subscribe.bylinetimes.com

A number of artists and creators have made their home on Bluesky, and we hear their concerns with other platforms training on their data. We do not use any of your content to train generative AI, and have no intention of doing so.

This was missed due to major live events happening around the same time, but we have released some of our high-resolution (2 Å) and rapid screening #cryoEM maps & models of the human CAK bound to small molecules. Paper still under review - more to follow. www.ebi.ac.uk/emdb/search/...