Sean Fanning
@docfanning.bsky.social
I am an Assistant Professor of Cancer Biology at Loyola University Chicago Stritch School of Medicine (www.fanninglab.com). The Fanning lab studies how allostery governs estrogen receptor-dependent transcriptional programs in breast cancer.
Register now for an amazing menu of endocine-related science and clinical practice! Early bird rate is ending soon! #ENDO2026
Endocrine Society@endocrinesociety.bsky.social · 4mo agoHurry! Only A Few Hours Left to Take Advantage of Lowest #ENDO2026 Rates | Register by tonight at 11:59 PM ET to receive the best rates. Don’t miss out! Join us at ENDO for an unforgettable experience of science, connection, and discovery: bit.ly/3Zn1sR9 #endocrinology #EndoSky
@cbartman.bsky.social I saw your post about Cas9 cells. Happy to share our MCF7 cas9 cells and gRNA protocol if you send a FedEx label for dry ice shipping.
How do hormones and diet influence the outcome of #cancer therapy? Wilbert Zwart (@zwartlab.bsky.social) of the @nkinl.bsky.social gave an amazing lecture on this topic at #KNCVMCCB2026 covering various strategies to use this information for improved treatments. www.nature.com/articles/s41...
The Trump administration's policies are taking a toll on the way researchers see a career in academia.
US researchers are advising students not to enter academia
A survey of NIH-grantees in Massachusetts reveals delayed hiring in labs, layoffs, careers being pursued abroad and research scope reductions
chemistryworld.com
Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodeling https://www.biorxiv.org/content/10.64898/2026.03.13.711653v1
Androgen Metabolism in Prostate Cancer: Recent Advances #metabolism #testosterone #prostatecancer url: academic.oup.com/endo/article...
Androgen Metabolism in Prostate Cancer: Recent Advances
Abstract. Androgen biosynthesis is physiologically necessary for generating the principal stimulus for androgen receptor (AR) signaling and thus plays an e
academic.oup.com
🎯 We are so thrilled our new paper @narjournal.bsky.social is out! Fantastic collab with the labs of Gordon Hager NIH & Franck Dequiedt. Heaviest lifting from Greg Fettweiss, Kaustub Wagh, Diana Stavreva & Alba Jiménez-Panizo. Big thanks to Andrea Alegre-Marti JdC 🥳✨️ academic.oup.com/nar/article/...
📢 Read our new bioRx in colab with Gordon Hager NIH @PabloFuentesP #FRecio @aguslafuent @PresmanLab @WaghKaustubh #IGoldstein et al where we found glucocorticoid receptor GR self-assembly, chromatin binding & activity is modulated by bile acids binding to a novel druggable site
Latest publication from our lab! A part of our ongoing efforts to identify estrogen receptor ligands that influence structural and oligomeric states in unique ways. pubs.acs.org/doi/10.1021/...
Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist
Complete estrogen receptor antagonists (CERANs) are effective against advanced estrogen receptor-positive (ER+) breast cancers, but current chemical scaffolds limit our ability to explore the full ran...
pubs.acs.org
🔊 Nova publicació del Dpt @bqbiomedmolub.bsky.social pel grup liderat per la Dra Eva Estébanez-Perpiñá @estebanezlab.bsky.social @ibub-ub.bsky.social @biologiaub.bsky.social Enhorabona! 👋👋
Eva Estébanez-Perpiñá, Ph.D.@estebanezlab.bsky.social · 10mo ago🎯 We are incredibly thrilled to share our newest paper on #NucleicAcidsResearch on Glucocorticoid Receptor Multimerization 👇 academic.oup.com/nar/article/... @ibub-ub.bsky.social @bqbiomedmolub.bsky.social @biologiaub.bsky.social @www.pcb.ub.edu
I know & trust that NIH staff will get this round of reviews done. Yet having done my own CSR reviews 'for nothing' & with my own R01 sitting unreviewed now, working on another NIH grant has never felt so painful and futile. A quiet impact on science, perhaps, robbing the joy from looking ahead.
NIH Vigils@nihvigils.bsky.social · 10mo agoIf you are serving on NIH study sections that have been cancelled, PLEASE continue to work on your reviews. NIH will do everything their power to ensure the meetings happen eventually, and the more prepared you are when those meetings are rescheduled, the better.
Democracy in action, Illinois. Proud of our state for peacefully showing up and speaking out together in one voice to fight back against Donald Trump’s takeover of our democracy.
Pop Crave@popcrave.com · 10mo agoView of the Anti-Trump ‘No Kings’ protest in Chicago.
Just wrapped up my medical school teaching for the year. I happened to have an exceptionally awesome group of M1s. I’m excited to see where they’ll go from here!
RFK Jr. and Trump tell us they want to Make America Healthy Again. Great slogan. I agree. Unfortunately, they are doing the exact opposite. Vaccines work. They are safe. They save lives. No more conspiracy theories. Kennedy must resign.
New York Times Opinion@nytopinion.nytimes.com · 11mo ago“Robert F. Kennedy Jr., the secretary of health and human services, is endangering the health of the American people now and into the future. He must resign,” Senator Bernie Sanders writes.
Fanning Lab BBQ 2025! Another good year in the books thanks to this exceptional group! Also, they wanted me to make ribs and brisket, they know I look for any excuse to do a cook.
I had a wonderful time at Endo2025, catching up with great colleagues doing fantastic and important work in endocrinology. I particularly enjoyed chairing the session on Nuclear Receptor Structural Biology where @dougkojetin.bsky.social gave a powerhouse performance! 1/3
New review from us on radiation in #lobular breast cancer! www.nature.com/articles/s41... Lots of anecdote that ILC is highly responsive to XRT (despite ~chemoresistance), but do we have the data? led by Dr. Michael Boysen (now resident at Trinity Health Ann Arbor), w Dr. Corey Speers @ UAB. 🧵1/n
Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity - npj Breast Cancer
npj Breast Cancer - Radiation therapy for lobular breast cancer: opportunities and challenges for leveraging radiosensitivity
nature.com
Finished another bronze of a T-cell attacking a cancer cell. This one is heading to Max Krummel at UCSF, who did some of the early studies on CTLA4 immunotherapy. #sciart.
Very proud of Sofia for successfully defending her Master’s thesis today!! She’s starting her PhD in biomedicine at UMiami next year. Can’t wait to see what she’ll accomplish! I’m a proud PI!
A careers feature in Nature Biotechnology provides some keys to a successful transition from a career in academia to one in industry. #Academicsky 🧪
Thinking about a move from academia to industry? Look before you leap - Nature Biotechnology
To those considering a change in careers from academia to the pharmaceutical industry, here are the keys to a successful transition.
go.nature.com
#Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments. The study was published in Nature Chemical Biology: go.mcb.illinois.edu/623 @nelsonlab.bsky.social
Colorectal cancer treated with cholesterol inhibitor in U. of I. study | School of Molecular & Cellular Biology | Illinois
University of Illinois researchers have successfully treated a common type of colorectal cancer tumor with a cholesterol inhibitor drug, demonstrating a promising treatment for the disease in animal experiments.
mcb.illinois.edu
We did a thing w @jostrander.bsky.social! Over the last few years, we took a new direction into #lobular breast cancer oncogenesis. We know loss of the gene CDH1 (E-cadherin) is central to ILC, and is among its earliest oncogenic events. But why? How does this push normal breast toward cancer? 1/n
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · last yr.CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells https://www.biorxiv.org/content/10.1101/2025.06.20.660633v1
Trump bombing Iran was illegal and unjustified. I ran for Congress to make sure our leaders consider the true costs of war. And I will be in the Senate, standing on my titanium legs, demanding answers from Trump. My statement:
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. #NEJM "zimislecel can restore physiologic islet function" Reference www.nejm.org/doi/full/10....
Super-resolution microscopy reveals distinct epigenetic states regulated by estrogen receptor activity https://www.biorxiv.org/content/10.1101/2025.06.16.659976v1
Congrats Xiuxiu Li on her story out JBC! HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer - Journal of Biological Chemistry @asbmb.bsky.social 🧪https://www.jbc.org/article/S0021-9258%2825%2902255-0/fulltext
HSD3B1 Upregulation via LRH1 Sustains Estrogen Receptor Signaling and Promotes Endocrine Resistance in Breast Cancer
Endocrine resistance is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancer, often leading to disease recurrence and metastasis. 3β-Hydroxysteroid dehydrogenase 1 (3βH...
jbc.org
What an amazing time to be a biomedical scientist. www.nejm.org/doi/abs/10.1...
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
nejm.org
