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Latest research from the lab out now. We examined the role and expression of fimbriae during UPEC bloodstream infection. A real team effort and brilliant collaboration with Mark Schembri’s lab in Brisbane. Thanks to the MRC and BBSRC for supporting our research @ukri.org

Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection

Author summary Extraintestinal pathogenic Escherichia coli (ExPEC) colonise the human gut without causing disease but can disseminate to the urinary tract and bloodstream. Understanding the mechanisms...

journals.plos.org

Tvp complexes support formation of the VgrG-PAAR spike during Type VI secretion system assembly Sarah Coulthurst and colleagues link.springer.com/article/10.1...

Tvp complexes support formation of the VgrG-PAAR spike during Type VI secretion system assembly - The EMBO Journal

Type VI secretion systems (T6SSs) are nanomachineries used by bacteria to inject toxic effectors into neighbouring cells during interbacterial competition or infection. Distinct paralogues of the stru...

link.springer.com

We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...

Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com

PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com

findaphd.com

Want to research the basis of how drug resistant bacteria interact with human immune cells? Fully funded 4-year PhD position available (UK home students). Come and join our amazing interdisciplinary team at the intersection of microbiology, immunity, metabolism and the clinic! Please spread the word

Hiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University on FindAPhD.com

PhD Project - Hiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University, listed on FindAPhD.com

findaphd.com

🌱 We’re excited to launch the BBSRC-funded UK Plant Epigenetics Network (UK-PEN) with our inaugural workshop (free!): “Plant Epigenetics: From Model to Crop Species” 📅 11–12 June 2026 📍 Uni of Dundee (hybrid) We look forward to welcoming you! Feel free to repost to help us reach the community

Sara Lopez-Gomollon@gomollonsara.bsky.social · 4mo ago

We are pleased to announce the launch of the BBSRC-funded UK Plant Epigenetics Network (UK-PEN) with our inaugural meeting (it is free!): 🌱 “Plant Epigenetics: From Model to Crop Species” 📅 11–12 June 2026 University of Dundee (hybrid event) We look forward to welcoming you!

How much protein diversity can Life on Earth actually generate? With DIAMOND DeepClust, we show how billions of proteins across the tree of life can be clustered at low-identity for downstream analytics tasks. 📚Paper: www.nature.com/articles/s41... 💻Code: github.com/bbuchfink/di...

Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com www.jobs.ac.uk/job/DQY475/r...

Research Fellow (Postdoctoral) at University of Birmingham

Explore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.

jobs.ac.uk

Now out in its final form, our investigation of how Pseudomonas aeruginosa manages resources to permit ongoing adaptations to environment during starvation: journals.asm.org/doi/10.1128/... Congrats to first author @findunmun1.bsky.social, and co-authors Claudia Hemsley and Elize Ambulte.

Pseudomonas aeruginosa dynamically prioritizes motility and resource recycling during prolonged starvation | mSystems

Molecular microbiology has traditionally focused on exponential growth in model organisms as the preferred context in which to study bacterial physiology, especially the regulation of new protein synt...

journals.asm.org

Here’s the latest preprint from my work on evolved resistance to Type VI Secretion system (T6SS) weaponry, funded by a @wellcometrust.bsky.social Sir Henry Wellcome Fellowship. So happy to see this out! www.biorxiv.org/content/10.6...

Tvp complexes support formation of the VgrG-PAAR spike during Type VI secretion system assembly https://www.biorxiv.org/content/10.64898/2026.02.23.707444v1

Congratulations to MD-PhD student, Amanda Velez and all co-authors on our new PNAS paper describing how the innate immune protein calprotectin incapacitates autolysins, inducing tolerance to B-lactam antibiotics. A fun collaboration with Thomas Kehl-Fie. www.pnas.org/doi/10.1073/...

Congratulations to Sean Yu-Hao Wang, Will DePas, @catarmbruster.bsky.social and colleagues on their use of experimental evolution to identify regulators of Mycobacterium abscessus biofilm production! www.sciencedirect.com/science/arti...

Experimental evolution in the cystic fibrosis chemical environment reveals early TCA cycle flux as a central regulator of Mycobacterium abscessus biofilm formation

Mycobacterium abscessus (MAB) is an emerging opportunistic pathogen that can cause severe, recalcitrant pulmonary infections in susceptible groups, in…

sciencedirect.com

Regulatory Rewiring Drives Intraspecies Competition in Bacillus subtilis bioRxiv from @bacteriacities.bsky.social #competition #rapP #comP www.biorxiv.org/content/10.1...

Regulatory Rewiring Drives Intraspecies Competition in Bacillus subtilis

Intraspecies interactions shapes microbial community structure and evolution, yet the mechanisms determining competitive outcomes among closely related strains remain unclear. The soil bacterium Bacil...

biorxiv.org

Identification of Previously Unknown DNA-Binding Proteins Using DNA Affinity/Pull-Down Methods Followed by Mass Spectrometry Jutras, Babb, Jusufovic, Krusenstjerna, Saylor, Verma, and Stevenson Current Protocols 2025, 5:e70264 doi: 10.1002/cpz1.70264 #MicroSky

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8

An Rhs effector uses distinct target cell functions to intoxicate bacterial and fungal competitors https://www.biorxiv.org/content/10.1101/2025.10.28.685041v1

Independent research fellowships leading to tenured positions at the John Innes Centre. Repost = nice. Thank you very much!!!

John Innes Centre@johninnescentre.bsky.social · 10mo ago

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...

New preprint from the lab! @findunmun1.bsky.social @chemsley.bsky.social We looked at new protein synthesis and genetic fitness during starvation in P. aeruginosa. Resources are dynamically redistributed to support ongoing activity, even over days of total starvation: www.biorxiv.org/content/10.1...

Analyses of protein expression and genetic fitness determinants reveal dynamic pathways active in starved Pseudomonas aeruginosa

Heterotrophic bacteria rapidly deplete essential macronutrients during growth and must navigate subsequent periods of growth arrest imposed by starvation. Nutrient limitations can be dynamic in nature...

biorxiv.org

yes, the MMBs studied by george schaible and roland hatzenpichler are fascinating 𝗼𝗯𝗹𝗶𝗴𝗮𝘁𝗲 𝗺𝘂𝗹𝘁𝗶𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 bacteria 🤩 STC had mentioned them first in 2007 > schaechter.asmblog.org/schaechter/2... and recently in > schaechter.asmblog.org/schaechter/2... #MicroSky

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ@nizet.bsky.social · last yr.

Fascinating new PLoS Biology paper from George Schaible et al in the Hatzenpichler Lab at Montana State “𝘈𝘴 𝘵𝘩𝘦 𝘰𝘯𝘭𝘺 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢 𝘵𝘩𝘢𝘵 𝘦𝘹𝘩𝘪𝘣𝘪𝘵 𝘰𝘣𝘭𝘪𝘨𝘢𝘵𝘦 𝘮𝘶𝘭𝘵𝘪𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳𝘪𝘵𝘺, 𝘔𝘔𝘉 𝘱𝘳𝘰𝘷𝘪𝘥𝘦 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘱𝘰𝘴𝘴𝘪𝘣𝘭𝘦 𝘮𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴 𝘣𝘦𝘩𝘪𝘯𝘥 𝘵𝘩𝘪𝘴 𝘱𝘳𝘰𝘧𝘰𝘶𝘯𝘥 𝘴𝘵𝘦𝘱 𝘪𝘯 𝘭𝘪𝘧𝘦’𝘴 𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘢𝘳𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘯 𝘌𝘢𝘳𝘵𝘩”

In @molecularmicro.bsky.social: two special issues on Prokaryotic Chromosome Organization. Many excellent contributions, including a vision article: 'Future directions of the Prokaryotic Chromosome Field', outcome of BioPhyChrom 2023 @biophychrom.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

Future Directions of the Prokaryotic Chromosome Field

In September 2023, the Biology and Physics of Prokaryotic Chromosomes meeting ran at the Lorentz Center in Leiden, The Netherlands. As part of the workshop, those in attendance developed a series of ....

onlinelibrary.wiley.com

Polyphosphate: The “Dark Matter” of Bacterial Chromatin Structure onlinelibrary.wiley.com/doi/10.1111/... #jcampubs

Polyphosphate: The “Dark Matter” of Bacterial Chromatin Structure

Polyphosphate condensates and their contributions to nucleoid structure. Polyphosphate condensates form in the ribosome-depleted nucleoid region of bacterial cells, particularly under stress (in this...

onlinelibrary.wiley.com

www.microbiologyresearch.org/content/jour...

Congrats to Findlay and many thanks to examiners Dan Neill and Martin Welch for their work on a successful viva today! Findlay has worked so hard and accomplished so much while blazing the trail as the first PhD student in the lab :)

Together with @frimanscience.bsky.social and our Chinese colleagues, we have worked out how to predict (i) siderophore molecular structures www.biorxiv.org/content/10.1... and (ii) siderophore interaction networks in communities www.biorxiv.org/content/10.1... from sequence data!