Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Do #lipids carry the signatures of #evolution?🤔 In #Biochemistry Perspective, We 'provocatively' (as my former PhD guide & scientific guru Sankar put it ) propose an expanded view of the classic “lipid divide” idea feedback/critiques all welcome 🙌 #lipidtime pubs.acs.org/doi/10.1021/...

An Integrative View on Multiple “Lipid Divide” Events as Hallmarks of Distinct Evolutionary Transitions

Lipids are fundamental to life, serving not only as membrane components but also as key players in signaling, energy storage, and cellular identity. While the well-known “lipid divide” between Bacteri...

pubs.acs.org

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

bioRxiv Biophysics@biorxiv-biophys.bsky.social · 11mo ago

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1

#NotTheCover @cellpress.bsky.social ...but, we’re still pretty proud of it! 😄 Had an awesome time putting this together with the amazing @kfreeman.bsky.social and @raphaelpark.bsky.social What a ride! 🚀 #SciArt #CryoET #CryoEM Paper👉 www.cell.com/cell/fulltex...

The very first structural images of a tuberculosis-fighting virus New insights could advance phage therapies for the world’s deadliest bacteria—including drug-resistant strains. www.scripps.edu/news...

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/... @yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

Scripps Research and @pittofficial.bsky.social capture the first cryo-EM & cryo-ET images of a virus infecting TB-causing Mycobacteria, revealing an unexpected infection mechanism that could inform phage therapies for drug-resistant TB, per @cellpress.bsky.social.

The very first structural images of a tuberculosis-fighting virus

scripps.edu

Some eye-catching #TeamTomo work here. Congrats to @kfreeman.bsky.social and all the authors! 🧪🧶🧬🔬

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ@nizet.bsky.social · last yr.

Krista Freeman et al 𝘊𝘌𝘓𝘓 stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm can inform precise targeted phage therapies for TB and NTM infections www.cell.com/cell/fulltex...

Host invasion by a mycobacteriophage—visualized in action! 🦠✨ Thrilled to have contributed to this exciting work! Great collaboration with the amazing Krista @kfreeman.bsky.social & Graham Hatfull lab. Huge thanks to the Park lab for this fantastic opportunity 🙌 #CryoEM #CryoET #phage #mycobacteria

Krista Freeman@kfreeman.bsky.social · last yr.

Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection. www.sciencedirect.com/science/arti...

Had an amazing week at the Gordon Research Conference on Biology of Mycobacteria! Great chats, exciting posters and the chance to meet both legends in the field and awesome new peers… #mycobacteria