Virus reactivation in acute and long COVID-19 - Nature

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

nature.com

#401 ‒ How curiosity transforms medicine: extraordinary discoveries that changed modern healthcare - Peter Attia MD

“The history of medicine is full of examples where we didn't invent the underlying mechanism. We discovered it, understood it, and then engineered it into something useful.” —Peter Attia

peterattiamd.com

A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence - Nature

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating in...

nature.com

Subtle Differences in RNA Have a Big Impact on Innate Immunity

New findings suggest subtle differences at the beginning of RNA molecules can affect how cells distinguish viral threats from harmless cellular RNA.

technologynetworks.com

PKR condensation at viral replication complexes initiates its activation

Blomqvist et al. show that protein kinase R (PKR) condensation on dsRNA exposed at MERS-CoV or ZIKV viral replication complexes initiates its activation. The NS4a protein encoded by MERS-CoV inhibits ...

cell.com

Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by suppressing antiviral responses

SARS-CoV-2 has evolved to optimize its replication fitness in the human host. This study shows that a nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness in...

journals.plos.org

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids

In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC gl…

sciencedirect.com

Postdoctoral Fellow

Job Posting Title: Postdoctoral Fellow ---- Hiring Department: Molecular Biosciences ---- Position Open To: All Applicants ---- Weekly Scheduled Hours: 40 ---- FLSA Status: Exempt ---- Earliest Start ...

utaustin.wd1.myworkdayjobs.com

A Break in a Longstanding Mystery about Origin of Complex Life

Breathe easy. It appears our microbial ancestors used oxygen, too.

cns.utexas.edu

Episode 13 - Simon Baker by Phil Lang is Not a Scientist

In this podcast I speak to Simon about his important research into the causes of bladder cancer, as well as his life and career.Story from Kidney Research UK about Simon's important breakthrough: http...

creators.spotify.com

mGem: Deciphering how polyomaviruses coexist with their hosts for a lifetime | mBio

It has been said that “Energy and persistence conquer all things” (Benjamin Franklin). Viral persistence refers to the ability of some viruses to establish long-term infections rather than being clear...

journals.asm.org

An Argonaute protein traffics from nematode to mouse and is a vaccine against parasitic nematodes - EMBO Reports

Argonautes are ancient proteins with well-characterised functions in cell-autonomous gene regulation and genome defence, but less clear roles in non-cell-autonomous processes. Extracellular Argonautes...

link.springer.com

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation

A model for hit-and-run viral carcinogenesis in the bladder.

science.org

Common Childhood Virus Causes DNA Damage Driving Bladder Cancer

The BK virus, which up to 80% of the population get infected with during childhood, can drive the development of bladder cancer down the line.

insideprecisionmedicine.com

Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells

Bats are reservoirs for many viruses that frequently cause epidemics in humans and animals. It is thus critical to better understand their immune system and mechanisms of antiviral immunity. Despite a...

biorxiv.org

Shedding dynamics of a DNA virus population during acute and long-term persistent infection

Author Summary/ Importance Polyomavirus infections, mostly benign but potentially fatal for immunocompromised individuals, undergo acute and long-term persistent infections. Typically, polyomavirus-as...

journals.plos.org

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.

science.org

Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

journals.plos.org

Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

dx.plos.org

Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

journals.plos.org

Shedding dynamics of a DNA virus population during acute and long-term persistent infection

Although much is known of the molecular mechanisms of virus infection within cells, substantially less is understood about within-host infection. Such knowledge is key to understanding how viruses tak...

biorxiv.org