Sébastien Pfeffer

@sebpfeffer.bsky.social

RNA biologist / Virologist / Director of IBMC RNA unit. CNRS, Strasbourg, France https://ibmc.cnrs.fr Working on #RNA and #virus. Mostly interested in #RNAi #microRNAs #innateimmunity #arboviruses

Ten months ago I had never written an op-ed. I believed the work spoke for itself. It doesn't. When the government calls a lifesaving technology unsafe and scientists stay silent, the silence becomes the story. A new @jhu.edu profile on why I stopped staying quiet: hub.jhu.edu/2026/06/24/j...

A staunch voice in support of science

Jeff Coller, a pioneering RNA biologist, has spent the past year vehemently advocating for the lifesaving promise of research in the face of federal cuts

hub.jhu.edu

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW

Pre-assembly of biomolecular condensate seeds drives RSV replication

Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

rdcu.be

Au terme d'une analyse totalement déconnectée de la réalité dont les crânes d'oeuf de Bercy ont le secret, Le gouvernement en déduit qu'il peut récupérer 1,4 milliards d'euros (sur 2,5) sur le dos des universités et de l'ANR principalement.

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Our latest paper on bat Dicer! 🦇 we show that Dicer antiviral RNAi activity is context-dependent also in bats 👩‍🔬 Specifically in Myotis myotis nasal epithelial cells, Dicer relocalizes to sites of viral replication upon alphavirus infection, which correlates with a proviral activity of Dicer 🦠

Sébastien Pfeffer@sebpfeffer.bsky.social · 8mo ago

Just in time for Christmas, here is the latest paper from the lab! Great work from @leagaucherand.bsky.social and Hugo Marie, with help from Julie Cremaschi. Funded by @frm-officiel.bsky.social, @agencerecherche.bsky.social journals.plos.org/plospathogen... @cnrsbiologie.bsky.social @unistra.fr

How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

science.org

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

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BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

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