The top frame is from 2015, when French meteorologists did a “forecast” from a #climate heated August 2050 - a warning on what could possibly happen in 35 years time. Bottom frame: well, it’s happened in barely a decade, only it’s already *much* worse than predicted. It’s a runaway train.
Sébastien Pfeffer
@sebpfeffer.bsky.social
RNA biologist / Virologist / Director of IBMC RNA unit. CNRS, Strasbourg, France https://ibmc.cnrs.fr Working on #RNA and #virus. Mostly interested in #RNAi #microRNAs #innateimmunity #arboviruses
Ten months ago I had never written an op-ed. I believed the work spoke for itself. It doesn't. When the government calls a lifesaving technology unsafe and scientists stay silent, the silence becomes the story. A new @jhu.edu profile on why I stopped staying quiet: hub.jhu.edu/2026/06/24/j...
A staunch voice in support of science
Jeff Coller, a pioneering RNA biologist, has spent the past year vehemently advocating for the lifesaving promise of research in the face of federal cuts
hub.jhu.edu
If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.
Arboviruses induce acute lytic infection in humans, but how can they infect #mosquito vectors without compromising host viability? This study shows that #arbovirus infection is maintained by limiting viral protein synthesis via repression of #viral RNA translation @plosbiology.org 🧪 plos.io/4tzdog6
Today we mourn the passing of our beloved central dogma. It served Crick well. But it is time to let go. www.science.org/doi/10.1126/...
Science | AAAS
science.org
🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS
Antisémitisme et critique d’Israël : à l’Assemblée, la mobilisation monte d’un cran contre la loi Yadan
Antisémitisme et critique d’Israël : à l’Assemblée, la mobilisation monte d’un cran contre la loi Yadan
Plus d’un demi-million de Français ont signé la pétition appelant les députés à voter contre la proposition de loi sur les « formes renouvelées de l’antisémitisme », portée par la macroniste Caroline Yadan. À gauche, on espère que la mobilisation citoyenne influencera les élus lors de l’examen du texte la semaine prochaine.
l.mediapart.fr
Poster abstracts and early bird registrations for the 31st Annual Meeting of the RNA Society are due by March 31st! RNA 2026 website: rnasociety.org/conferences/ #RNA26
Max Fels @mfels.bsky.social from our lab discovers giant DNA viruses that infect amoeba encode eIF4E and the entire suite of 4F complex proteins to control mRNA translation, including beautiful crystal structures of viral 4E bound to modified mRNA 5' caps: www.cell.com/cell/fulltex...
Don't miss this great opportunity!
L’IGFL recrute un•e Professeur•e des Universités en biologie moléculaire (CNU 64), UCBL Lyon 1. Enseignement L2-M2 (Biochimie et Biologie Moléculaire) + projet en biologie moléculaire des eucaryotes au sein de l’IGFL. Détails: shorturl.at/K5Dno #Recrutement #BiologieMoleculaire
Group Leader Call at the @cbitoulouse.bsky.social in Genome biology, projects at the interface with devbio will be given particular attention. please share :) cbi-toulouse.fr/wp-content/u...
cbi-toulouse.fr
#PressRelease🗞️ A specific molecular mechanism has been identified as the cause of the most frequent genetic forms of amyotrophic lateral sclerosis (ALS, also known as Charcot’s disease) and frontotemporal dementia (FTD). 👉 www.cnrs.fr/en/press/discov...
Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW
Pre-assembly of biomolecular condensate seeds drives RSV replication
Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.
rdcu.be
Au terme d'une analyse totalement déconnectée de la réalité dont les crânes d'oeuf de Bercy ont le secret, Le gouvernement en déduit qu'il peut récupérer 1,4 milliards d'euros (sur 2,5) sur le dos des universités et de l'ANR principalement.
#RNAi is an ancestral #antiviral system that degrades viral RNA, but what about in #cnidarians? @yehumoran.bsky.social &co show that #Nematostella has an siRNA-mediated antiviral response that lacks 2ary amplification & functions as a short-term antiviral mechanism @plosbiology.org 🧪 plos.io/3N192OD
Our latest paper on bat Dicer! 🦇 we show that Dicer antiviral RNAi activity is context-dependent also in bats 👩🔬 Specifically in Myotis myotis nasal epithelial cells, Dicer relocalizes to sites of viral replication upon alphavirus infection, which correlates with a proviral activity of Dicer 🦠
Just in time for Christmas, here is the latest paper from the lab! Great work from @leagaucherand.bsky.social and Hugo Marie, with help from Julie Cremaschi. Funded by @frm-officiel.bsky.social, @agencerecherche.bsky.social journals.plos.org/plospathogen... @cnrsbiologie.bsky.social @unistra.fr
Just in time for Christmas, here is the latest paper from the lab! Great work from @leagaucherand.bsky.social and Hugo Marie, with help from Julie Cremaschi. Funded by @frm-officiel.bsky.social, @agencerecherche.bsky.social journals.plos.org/plospathogen... @cnrsbiologie.bsky.social @unistra.fr
Bat Dicer antiviral role and subcellular localization differ upon alphavirus infection in two distinct species
Author summary Bats are important to study as they are reservoirs for many viruses that can cause severe disease in humans. Notably, bats often show no clinical symptoms when infected with these virus...
journals.plos.org
Yesterday was a good day for the lab with a paper accepted (congrats @leagaucherand.bsky.social and Hugo Marie !) and a very nice Christmas dinner 🎅
[ #VeilleESR #LPPR ] Pour fêter ses 20 ans, le gouvernement envisage de baisser le budget de l'@agencerecherche.bsky.social @claire-giry.bsky.social par @antoinebeau.bsky.social et @stephaniebenz.bsky.social
"Le financement de nouveaux projets de recherche est menacé" : l'alerte de Claire Giry (ANR)
L'Agence nationale de la recherche fête ses 20 ans dans un contexte de grandes tensions budgétaires. Sa présidente Claire Giry revient sur son bilan et décrypte les enjeux du moment.
lexpress.fr
How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
science.org
#RejoignezLeCNRS 🫵 Les concours chercheurs CNRS 2026 ouvrent le 8/12 ! Envie de faire avancer la science au sein d’un des plus grands organismes de recherche ? 👉 carrieres.cnrs.fr/concours-... #ConcoursChercheurs #Science #Recherche #Icicarecrute #recrutement
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Are bats tolerant of all viruses? With a comparative -omics approach, we show that Egyptian fruit bat cells show both antiviral and pro-inflammatory immune responses to infection with Zika virus while our Jamaican fruit bat cells are not susceptible. www.biorxiv.org/content/10.1...
Ce mépris venu de l’Élysée Par @ilyesramdani.bsky.social
Ce mépris venu de l’Élysée
La reconduction de Sébastien Lecornu à Matignon, cinq jours après sa démission, est stupéfiante parce qu’insensée. Le président de la République a définitivement renoncé à aligner ses décisions sur les aspirations populaires. Seule compte à présent la conservation du pouvoir.
l.mediapart.fr
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉 www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...
pnas.org
Want to connect with researchers in #GeneRegulation, small RNAs, #StructuralBiology and more? Sign up for EMBO Workshop "RNA-guided genome protection" in Caux, Switzerland, 16–20 June 2026! Deadline: 15 March meetings.embo.org/event/26-gen... #DNAsky #RNAsky #EMBORNAGenomeProtection #EMBOevents 🧪
RNA-guided genome protection
The genome carries information across generations, ensuring species survival. To preserve faithful transmission of genetic information, RNA-directed mechanisms safeguard the genome integrity in diver…
meetings.embo.org