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SUNRiSE network

@sunrise-network.bsky.social

The “Stem Cells and Solid Tumors” network SUNRiSE (Solid Tumor Cancer Stem Cell Network) aims to promote fundamental and applied research in the field of cancer stem cells of solid tumors.

20 Posts113 Follower140 Folgt
SUNRiSE network@sunrise-network.bsky.social · 6mo ago

Bonjour à tous, Les inscriptions pour notre formation annuelle sur les technologies émergentes pour explorer l'hétérogénéité tumorale sont ouvertes ! N'hésitez pas à vous inscrire et/ou à partager à votre réseau 😀

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SUNRiSE network@sunrise-network.bsky.social · 6mo ago

8e Formation SUNRiSE : 2 & 3 mars 2026! Venez vous former aux technologies récentes pour étudier les cellules souches cancéreuses et la plasticité tumorale auprès d'experts dans le domaine! Informations ici: www.sunrise-network.fr/fr/event/7e-...

8e Formation SUNRiSE : 2 & 3 mars 2026 - Sunrise

HETEROGENEITE ET PLASTICITE TUMORALE : LES NOUVELLES TECHNOLOGIES POUR EXPLORER L’ECOSYSTEME TUMORAL 8e SESSION DE FORMATION DU RESEAU SUNRiSE 2 au 3 mars 2026, On line Objectif : Cette formation se d...

sunrise-network.fr

SUNRiSE network@sunrise-network.bsky.social · last yr.

Amazing job! Well done guys! Funny how conventional therapies enrich for hybrid GBM cells🤩

Giorgio Seano@giorgioseano.bsky.social · last yr.

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo... Short walkthrough below. Let’s dive in! 🧵 (1/9) #GBM, #BrainTumor

Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear. Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population. Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies. Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.
CNRS Biologie@cnrsbiologie.bsky.social · last yr.

🐠✨ Comment le poisson-clown échappe-t-il aux toxines de son anémone protectrice ? Grâce à… son mucus ! 🧐 Un nouvel épisode passionnant du podcast Avec Sciences sur @franceculture.fr explore cette incroyable adaptation. 🌊🔬 🎧 À écouter ici 👉 buff.ly/3XoPQwj

Le poisson-clown résiste aux toxines de l’anémone qui l’abrite grâce à son mucus

Une nouvelle publication dans la revue BMC Biology estime que la résistance du poisson-clown aux toxines des anémones résiderait dans son mucus, la substance visqueuse qui le recouvre.

buff.ly

CNRS Biologie@cnrsbiologie.bsky.social · last yr.

#RésultatScientifique 🔎 Découvrez la dernière publication de Yann Guérardel, Vincent Laudet et leurs collaborateurs 🤝 @cnrs-hautsdefrance.bsky.social @cnrsoccitanieest.bsky.social @univlille.bsky.social @ugsf-lille.bsky.social 👉 https://buff.ly/40UKcTI

Eric Topol@erictopol.bsky.social · 2y ago

A very innovative approach to cancer: engineering fat cells to convert to beige fat to starve tumors, outcompeting 5 types of cancer in experimental models www.nature.com/articles/s41... @naturebiotech.bsky.social y.social @nadavahituv.bsky.social tuv.bsky.social

Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.

nature.com

@brumbaugh-lab.bsky.social · 2y ago

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

rdcu.be