@brumbaugh-lab.bsky.social
I'm looking forward to the career panel this year at the annual meeting for the International Society for Stem Cell Research! If you are going to be in Montreal and have an interest, come check us out. #ISSCR2026 invt.io/1bxb8rgcvr3 @isscr.org
I'm speaking at ISSCR 2026 Annual Meeting, join me
Register now
invt.io
I am working with @stemcellnetwork.ca & @isscr.org to understand the needs of trainees & employers in regenerative medicine. We are seeking input through a brief survey: lnkd.in/eFdbYQrr Help inform future training and workforce development by completing the survey and sharing it with your networks!
2026 ISSCR-SCN Workforce Survey
Please click the link to complete this form.
lnkd.in
Stem Cell Network@stemcellnetwork.ca · 2mo ago(1/2) 📣 Help shape the future of workforce development in #StemCells and #RegenerativeMedicine! SCN and @isscr.org invite members of the global stem cell research and regenerative medicine community – from all career stages – 🔗 form.jotform.com/261107195653...
(1/2) 📣 Help shape the future of workforce development in #StemCells and #RegenerativeMedicine! SCN and @isscr.org invite members of the global stem cell research and regenerative medicine community – from all career stages – 🔗 form.jotform.com/261107195653...
Check out our new preprint: (www.biorxiv.org/content/10.6...) that highlights estrogen signaling in trophoblast development. Our data suggest that increased dosage of NRIP1 impairs this pathway, contributing to placental defects linked to Down syndrome. Great work @deirdrelogsdon.bsky.social & team!
The @isscr.org and @stemcellnetwork.ca have launched a working group on Global Workforce Development in Stem Cell Research and Regenerative Medicine. I'm excited to co-chair this initiative with Dr. Danielle Spice and to work with an impressive set of trainees and early-career investigators. (1/2)
Cool study from the @efapostolou29.bsky.social looking at plasticity in B cells. Check it out!
Effie Apostolou lab@efapostolou29.bsky.social · 7mo agoOur study with @melnicklab on the discovery of a transient and tightly-regulated, plastic state of mature B cells during physiological immune response and potential links to aggressive lymphomas now out at NCB.👇Detailed threat by the amazing lead author @lscourzic.bsky.social!. .
The @isscr.org and @stemcellnetwork.ca have launched an important initiative to understand the needs of both employers and the future workforce. Check out the information below and consider applying to join the working group or nominate someone that you feel could provide good perspective!
ISSCR@isscr.org · 9mo agoThe ISSCR and Stem Cell Network are seeking nominations to form a working group of early career scientists and senior trainees in stem cell and regenerative medicine research who will provide perspectives on global workforce development. Nominations are due 5 December 👉https://ow.ly/cwau50XnYnF
There are many ways to make your voice heard and participate in all that the #ISSCR2026 Annual Meeting has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1lxby1coomp @isscr.org
Fun project with @distefanolab.bsky.social looking at RNA regulation in cell fate decisions. Check out the great summary below and see the full work in @natbiotech.nature.com: www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
nature.com
Bruno Di Stefano@distefanolab.bsky.social · 9mo ago1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.
Bruno Di Stefano@distefanolab.bsky.social · last yr.New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...
Thanks to @isscr.org for this wonderful recognition! And thanks to my colleagues and ISSCR for thoughtfully and carefully working on important policy and regulatory matters. Read more about the award and my fellow honorees. invt.io/1bxbk540w9k @isscr.org
I am a 2025 ISSCR Public Service Award Honoree.
Learn more
invt.io
Thanks to @cp-cellchembiol.bsky.social, @iamzico.bsky.social and Ramesh Shivdasani for this thoughtful discussion of our work!
Cell Chemical Biology@cp-cellchembiol.bsky.social · last yr.🔦Spotlight of Peter Dempsey, @brumbaugh-lab.bsky.social et al paper: Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells by @iamzico.bsky.social and Ramesh Shivdasani at @danafarber.bsky.social http://dlvr.it/TJfVRZ
Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells
Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic bac...
cell.com
💫NEW: @brumbaugh-lab.bsky.social, Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment, whereas its suppression induces a plastic state and expression of genes involved in #regeneration. 👉🏿https://rdcu.be/eayN3 www.nature.com/articles/s41...
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium - Nature Cell Biology
Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state and expression of genes ...
nature.com
🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration. rdcu.be/d8awu www.nature.com/articles/s41...
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
rdcu.be
1/ Pleased to share our review, published today @natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
Biomolecular condensates in immune cell fate - Nature Reviews Immunology
Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...
nature.com
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
rdcu.be