Severe Covid leads to persistent viral reactivation, with >10 different viruses noted in the first 40 days after hospital admission. Long Covid was specifically associated with reactivation of latent Anelloviridae virus @nature.com www.nature.com/articles/s41...

Virus reactivation in acute and long COVID-19 - Nature

Chronic reactivation of distinct herpesviruses and anelloviruses occur during acute and long COVID-19, and track with disease severity, inflammation and outcomes, revealing immune signatures with prog...

nature.com

As many said, I also think @wikipedia.org is one of the rare good places remained on the internet. Wikipedia is 25! If you use it all the time and want to protect a future where knowledge is human-made, join me and donate now: donate.wikipedia25.org #Wikipedia25

A Sharon Begley byline, almost 5 years after her death. Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written." Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating. 🧪🧬🧫

James Watson, dead at 97, was a scientific legend and a pariah among his peers

James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.

statnews.com

That merely being “under review” by a Nature family journal is offered as a quality proxy for a paper is a tragic illustration of the extent to which academia is addicted to brands and outsources evaluation

@biorxivpreprint.bsky.social Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus www.biorxiv.org/content/10.1...

Integrated epigenetic and genetic programming of primary human T cells - @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social @j-eyquem.bsky.social @marsonlab.bsky.social go.nature.com/3WOJJAJ

Integrated epigenetic and genetic programming of primary human T cells - Nature Biotechnology

Multiplexed editing in primary human T cells generates enhanced immune cell therapies.

go.nature.com

Very good 😂. This describes a lot of what is going on accurately. Credit: @integralanswers.bsky.social

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization Original antigenic sin? No, memory B cells are predominantly recruited to the germinal center, where they undergo further selection and affinity maturation. www.science.org/doi/... 1/4

Germinal center–mediated broadening of B cell responses to SARS-CoV-2 booster immunization

SARS-CoV-2 variant booster vaccination broadens human B cell responses through the germinal center reaction.

science.org

Statistics on 100 million people - I repeat - 100 million people‼️‼️⚠️ Says #shingles vaccine reduces risk of #dementia of 20-30%. This is mind blowing 🤯 www.nature.com/articles/s41...

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

nature.com

Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles: www.sciencedirect.com/science/arti... @jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social

The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences

The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…

sciencedirect.com

1/6 🧬 NEW COMMENTARY 🧬 Let’s talk about the challenges in immunoglobulin (IG) & T cell receptor (TR) gene nomenclature in the era of modern genomics. A 🧵 on why it’s time to rethink how we name these genes—and what it means for immunogenetics. #IGTR #Genomics #Immunology

This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!

@KingOfPathogens@kingofpathogens.bsky.social · last yr.

We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below: www.science.org/doi/10.1126/... @cytokinesociety.bsky.social

And the second day of #ATCR25 also came to an end. Felt the meeting was a real fresh air of ideas. Super glad I joined. The best part is always to meet with old friends, and the #goodscience of course 😉 I love the location in Antwerp too 😍

First day of #ATCR25 in Antwerp: done ☑️ 🤩 Picture of Antwerp city station #immunology #TCRrepertoire #Tcells #research

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

'Unparalleled' snake antivenom made from man bitten 200 times The blood of a US man who deliberately injected himself with snake venom for nearly two decades has led to an "unparalleled" antivenom, say scientists. www.bbc.com/news/art... 1/8

'Unparalleled' snake antivenom made from man bitten 200 times

Scientists hope to make a universal antivenom from the extraordinary blood of a man exposed to snake venom for decades.

bbc.com

New @science.org An innovative way to deliver drugs to the gut at low doses to suppress inflammation www.science.org/doi/10.1126/...

Cool pre-print in my feeds this morning, using a neat trick weighting TCRs by similarity prior to DGE better resolve differential usage. Seems to be a clever trick to make TCRseq behave a little more like regular RNAseq data and better use regular stats/tools: www.biorxiv.org/content/10.1...

Differential T cell receptor gene expression analysis using the Wilcoxon test with similarity-based weighting

To better understand immune responses, comparing the abundance of T cell receptors (TCRs) between conditions can provide insights into which T cells have proliferated or were involved in immune activa...

biorxiv.org

www.nature.com/articles/s41...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

nature.com

This looks super interesting www.biorxiv.org/content/10.1...

Ultra long-lived plasma cells in the human small intestine produce microbiota-reactive IgA antibodies

A large fraction of the intestinal microbiota is highly coated with secretory IgA, and bacteria-specific IgA is believed to shape the composition of the microbiota. A hallmark of the adaptive immune s...

biorxiv.org

Direct presentation of endogenous antigen on MHC II is crucial to mRNA-LNP vaccine-induced immune responses doi.org/10.1101/2025...

42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes doi.org/10.1002/cyto...

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis www.sciencedirect.com/science/arti...

T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Self-peptide-dependent autoproliferation (AP) of B and T cells i…

sciencedirect.com

check out our new manuscript (led by Gian Marco Visani): structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides: arxiv.org/abs/2503.00648

Excited to see our new single cell immunology tool out now in @naturecomms.bsky.social. We made "Single cell suppression profiling of human regulatory T cells" to generate a human model to screen for cell-type specific effects on all immune cells simultaneously. www.nature.com/articles/s41...

More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.

Mass firings decimate U.S. science agencies

White House dismissals and rationale challenged by dismissed scientists and lawsuits

scim.ag

Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease @cp-cellreports.bsky.social www.cell.com/cell-reports... @anukulshenoy.bsky.social

Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 www.nature.com/articles/s41...

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci - Nature Biotechnology

Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.

nature.com

To read: www.science.org/doi/10.1126/...

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection

Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress d...

science.org