Looking for a new postdoc to join my lab at the Fred Hutch in Seattle. Keen to find someone excited to dive into the mechanisms underlying microbial control of immune system recovery after transplant and immunotherapy! careers-fhcrc.icims.com/jobs/31336/p...

Fred Hutchinson Cancer Center

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

careers-fhcrc.icims.com

We are hiring! We have a postdoc position opened @fredhutch.org to join our team to design next gen cellular therapies for cancer. Heavy focus on T cell signaling and understanding how synthetic receptors instruct T cells to fight cancer.

Hey @jamieheather.bsky.social what do you think of this? www.biorxiv.org/content/10.1...

Targeting peptide-MHC complexes with designed T cell receptors and antibodies

Class I major histocompatibility complexes (MHCs), expressed on the surface of all nucleated cells, present peptides derived from intracellular proteins for surveillance by T cells. The precise recogn...

biorxiv.org

Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...

TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods

TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.

nature.com

Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy @natcancer.nature.com www.nature.com/articles/s43...

Excited to announce that I’ve recently transitioned into an Assistant Professor role in the Division of Translational Science and Therapeutics @Fred Hutch.

Check out one of our latest stories about combining our non viral knock-in strategy with integrases for an efficient, targeted integration of transgenes >8kb in human T cells! ‘One-pot’ PASTA: programmable and site specific transgene addition - all in just one reaction 🫕

Dimitrios L. Wagner@dlwagner.bsky.social · 11mo ago

You like engineering T cells, but you are missing the right flavor? Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1 We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt 𝐏rogrammable 𝐀nd 𝐒ite-specific 𝐓ransgene 𝐀ddition 🧪

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+ Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade www.biorxiv.org/content/10.1...

Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis blockade https://www.biorxiv.org/content/10.1101/2025.04.10.648245v1

Exciting news! Our latest manuscript is out! Really happy to report on the development of synthetic chimeric TCRs with enhanced antigen sensitivity and capable of bispecificity to successfully overcome tumor heterogeneity in pre-clinical models. Check it out: rdcu.be/edRwJ

Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy

Nature Cancer - Simon, Bugos and colleagues report the design and characterization of monospecific and bispecific synthetic chimeric T cell receptors, conferring increased antigen sensitivity and...

rdcu.be

Flow cytometry batch effect correction without requiring normalization controls 🤩 onlinelibrary.wiley.com/doi/full/10....

CytoNorm 2.0: A flexible normalization framework for cytometry data without requiring dedicated controls

Cytometry is a single cell, high-dimensional, high-throughput technique that is being applied across a range of disciplines. However, many elements alongside the data acquisition process might give r...

onlinelibrary.wiley.com

Make sure you, your trainees, and anyone else who might listen to you understands what "indirects" actually are, how they are established, and what Universities contribute. H/T @rodallab.bsky.social Please share widely! www.youtube.com/watch?v=yxTD...

Facilities and Administrative (F&A) Costs Explainer

YouTube video by Association of American Universities

youtube.com

👀 🤯

Di Jiang@dijiang319.bsky.social · last yr.

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social